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  Domain Name: KR
KR domain. This enzymatic domain is part of bacterial polyketide synthases and catalyzes the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
No pairwise interactions found for the domain KR

Total Mutations Found: 44
Total Disease Mutations Found: 29
This domain occurred 29 times on human genes (56 proteins).



  17-@BETA-HYDROXYSTEROID DEHYDROGENASE X DEFICIENCY
  CORTISONE REDUCTASE DEFICIENCY 2
  CRANIOOSTEOARTHROPATHY
  D-BIFUNCTIONAL PROTEIN DEFICIENCY
  EPIMERASE-DEFICIENCY GALACTOSEMIA (EDG)
  FUNDUS ALBIPUNCTATUS, AUTOSOMAL RECESSIVE
  GALACTOSE EPIMERASE DEFICIENCY
  GALACTOSE EPIMERASE DEFICIENCY, SEVERE
  LEBER CONGENITAL AMAUROSIS 13
  MENTAL RETARDATION, X-LINKED, SYNDROMIC 10
  RETINITIS PIGMENTOSA 53


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for KR











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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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