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  Domain Name: LAP2alpha
Lamina-associated polypeptide 2 alpha. LAPs are components of the nuclear lamina which supports the nuclear envelope.LAP2alpha is a non-membrane-associated member of the LAP family which is unique. This family of proteins is the C terminal domain of LAP2alpha which consists of residues 459-693 and constitutes a dimeric structure with an antiparallel coiled coil. LAP2alpha is involved in cell-cycle regulation and chromatin organisation and preferentially binds to lamin A/C.
No pairwise interactions found for the domain LAP2alpha

Total Mutations Found: 4
Total Disease Mutations Found: 1
This domain occurred 1 times on human genes (2 proteins).



  CARDIOMYOPATHY, DILATED, 1T


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for LAP2alpha











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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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