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  Domain Name: PLCYc
Phospholipase C, catalytic domain (part); domain Y. Phosphoinositide-specific phospholipases C. These enzymes contain 2 regions (X and Y) which together form a TIM barrel-like structure containing the active site residues. Phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The bacterial enzyme appears to be a homologue of the mammalian PLCs.
No pairwise interactions found for the domain PLCYc

Total Mutations Found: 17
Total Disease Mutations Found: 11
This domain occurred 15 times on human genes (30 proteins).



  AURICULOCONDYLAR SYNDROME 2
  NAIL DISORDER, NONSYNDROMIC CONGENITAL, 3


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PLCYc








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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