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  Domain Name: Patched
Patched family. The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
No pairwise interactions found for the domain Patched

Total Mutations Found: 59
Total Disease Mutations Found: 35
This domain occurred 7 times on human genes (17 proteins).



  EZETIMIBE, NONRESPONSE TO
  HOLOPROSENCEPHALY 7
  NIEMANN-PICK DISEASE, TYPE C1
  NIEMANN-PICK DISEASE, TYPE C1, ADULT FORM
  NIEMANN-PICK DISEASE, TYPE C1, JUVENILE FORM
  NIEMANN-PICK DISEASE, TYPE D
  NIEMANN-PICK DISEASE, VARIANT TYPE C1


Tips:
 If you've navigated here from a protein, hovering over a position on the weblogo will display the corresponding protein position for that domain position.

 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Patched































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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