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  Domain Name: TCP1_gamma
TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), each ring of the eukaryotic cytosolic chaperonin (CTT) consists of eight different, but homologous subunits. Their common function is to sequester nonnative proteins inside their central cavity and promote folding by using energy derived from ATP hydrolysis. The best studied in vivo substrates of CTT are actin and tubulin.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 9
Total Disease Mutations Found: 2
This domain occurred 10 times on human genes (14 proteins).



  LEUKODYSTROPHY, HYPOMYELINATING, 4
  SPASTIC PARAPLEGIA 13


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
stacking interactions
ring oligomerisation inte
ATP/Mg binding site























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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