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  Domain Name: alkPPc
Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 45
Total Disease Mutations Found: 36
This domain occurred 4 times on human genes (8 proteins).



  HYPOPHOSPHATASIA, ADULT
  HYPOPHOSPHATASIA, ADULT, INCLUDED
  HYPOPHOSPHATASIA, ADULT, INCLUDED;;
  HYPOPHOSPHATASIA, CHILDHOOD
  HYPOPHOSPHATASIA, CHILDHOOD, INCLUDED
  HYPOPHOSPHATASIA, CHILDHOOD, INCLUDED;;
  HYPOPHOSPHATASIA, INFANTILE
  ODONTOHYPOPHOSPHATASIA
  ODONTOHYPOPHOSPHATASIA, INCLUDED


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
active site
dimer interface























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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