Speaker: Maricel Kann

Start Date: Friday, September 05, 2008, 01:00PM

Location: LH 8 ITE building

Abstract: Protein domains, or domains, are the evolutionary, structural and functional units of the proteins. Despite the obvious relevance of domains to understanding biological process at the molecular level, most high-throughput experimental data relating molecular information to biological process, including diseases, is only analyzed at the gene or protein level. I will introduce a new approach, the protein domain profiling, to analyze clinical data derived from microarray and other experimental high-throughput technology. I will show how to use this approach to integrate mutational, alternative splicing and other molecular events with protein interaction and gene expression. In addition, I will introduce HPDD, a database of human protein domains available at http://bioinf.umbc.edu/hpdd which provides a unique resource for study of protein domains and human diseases.

Parallel Computing on the Distributed-memory Cluster hpc for Large-scale Simulations of Transient Partial Differential Equations

Speaker: Matthias Gobbert

Start Date: Wednesday, September 10, 2008, 12:00PM

Location: Biological Sciences 004

Abstract:Parallel computing holds great potential both for solving larger problems and for solving them faster than possible on a serial computer. This talk will discuss the concepts and goals of parallel computing and introduce the distributed-memory cluster hpc with state-of-the-art InfiniBand interconnect network in the new UMBC High Performance Computing Facility (HPCF). The numerical simulations for a model of calcium flow in a heart cell serves as example for the combination of appropriate numerical algorithm, its efficient implementation, and crucial hardware components that is necessary to achieve excellent parallel performance. There will be plenty of time to discuss questions from the audience about the new cluster, the HPCF, and how researchers at UMBC can participate.

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