Results for the protein: NP

Results for the Protein: NP_619725

116284373

5468

PPARG

NCBI

peroxisome proliferator-activated receptor gamma isoform 1 [Homo sapiens]

Known Diseases associated with this Protein:
  COLON CANCER, SOMATIC
  LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
  OBESITY, SEVERE

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Tips:

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RefSeq Protein: NP_619725

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
NR_DBD_DHR4_like	cd07168	2.6e-31	100	191
NR_DBD_VDR	cd06955	5.9e-16	103	206
NR_DBD_PNR	cd06970	4.8e-25	103	192
NR_DBD_TLX	cd07163	7.1e-23	103	191
NR_DBD_GCNF_like	cd07169	5.5e-29	103	191
NR_DBD_ROR	cd06968	2e-33	104	197
NR_DBD_RAR	cd06964	5.2e-32	105	188
NR_DBD_ERR	cd07170	2.4e-20	105	201
NR_DBD_TR2_like	cd06967	1.8e-31	106	191
NR_DBD_REV_ERB	cd07166	1.1e-44	106	192
NR_DBD_ER	cd07171	1.7e-21	106	186
NR_DBD_AR	cd07173	2.6e-09	106	187
NR_DBD_GR_PR	cd07172	6.2e-09	107	183
NR_DBD_NGFI-B	cd06969	2.3e-32	109	182
NR_DBD_EcR_like	cd06959	3e-23	110	181
NR_DBD_TR	cd06961	2.1e-33	110	193
NR_DBD_Ppar	cd06965	1.2e-57	110	193
2DBD_NR_DBD1	cd07157	4.2e-14	110	191
NR_DBD_like	cd06916	1.8e-43	111	181
NR_DBD_RXR	cd06956	9.4e-31	111	184
NR_DBD_PNR_like_2	cd06957	6e-23	111	190
NR_DBD_COUP_TF	cd06958	5.4e-25	111	182
NR_DBD_HNF4A	cd06960	4.3e-31	111	185
NR_DBD_FXR	cd06962	1.6e-17	111	190
NR_DBD_GR_like	cd06963	1.9e-12	111	182
NR_DBD_CAR	cd06966	4.7e-13	111	201
NR_DBD_PNR_like	cd07154	4.2e-26	111	181
NR_DBD_ER_like	cd07155	2.1e-23	111	184
NR_DBD_VDR_like	cd07156	7.7e-25	111	181
NR_DBD_Ppar_like	cd07158	7.8e-47	111	181
NR_DBD_EcR	cd07161	1.8e-19	111	196
NR_DBD_PXR	cd07162	1.2e-20	111	199
NR_DBD_PNR_like_1	cd07164	1.3e-25	111	187
NR_DBD_Lrh-1_like	cd07167	9.1e-27	111	203
2DBD_NR_DBD2	cd07179	1.8e-32	111	183
NR_DBD_DmE78_like	cd07165	4.3e-41	111	190
NR_LBD_VDR	cd06933	2.1e-07	175	477
NR_LBD_PXR_like	cd06934	1.3e-05	208	472
NR_LBD_PPAR	cd06932	3.5e-176	209	476
NR_LBD_LXR	cd06954	2.4e-10	212	476
NR_LBD_ROR_like	cd06939	1e-10	223	477
NR_LBD_DHR38_like	cd07072	0.00047	224	477
NR_LBD_TR	cd06935	2.9e-07	227	472
NR_LBD_NGFI-B	cd07348	7.4e-05	233	477
NR_LBD_EcR	cd06938	4.7e-09	240	476
NR_LBD_Nurr1_like	cd06945	0.00041	240	477
NR_LBD_Ftz-F1_like	cd06944	0.00047	245	476
NR_LBD_HNF4_like	cd06931	3e-07	251	472
NR_LBD_ERR	cd06946	0.00031	252	475
NR_LBD_ER_like	cd07068	2.9e-06	253	475
NR_LBD_RAR	cd06937	2e-11	256	475
NR_LBD_RXR_like	cd06943	1.9e-08	256	454
NR_LBD_Fxr	cd06936	9.9e-09	258	471
NR_LBD_Tlx_PNR_like	cd06950	0.00026	259	462
NR_LBD_COUP-TF	cd06948	0.00041	262	472
NR_LBD_REV_ERB	cd06940	1.8e-27	268	458
NR_LBD_F1	cd06929	2.5e-67	279	453
NR_LBD_DmE78_like	cd06941	1.6e-24	281	474
NR_LBD_F2	cd06930	2.1e-06	282	445
NR_LBD_Sex_1_like	cd06942	1.2e-08	282	470
NR_LBD	cd06157	3e-44	283	445
zf-C4	pfam00105	1.1e-41	109	177
Hormone_recep	pfam00104	4.3e-33	313	472
PPARgamma_N	pfam12577	1.3e-08	39	80
ZnF_C4	smart00399	1.4e-35	110	178
HOLI	smart00430	1.9e-26	289	445

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	601487.0013	Disease	p.ARG397CYS	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0006	Disease	p.ARG260HIS	COLON CANCER, SOMATIC
OMIM	601487.0015	Disease	p.ARG166TRP	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0014	Disease	p.CYS162SER	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0004	Disease	p.GLN258PRO	COLON CANCER, SOMATIC
OMIM	601487.0005	Disease	p.LYS291TER	COLON CANCER, SOMATIC
OMIM	601487.0012	Disease	p.PHE360LEU	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0001	Disease	p.PRO87GLN	OBESITY, SEVERE
OMIM	601487.0007	Disease	p.PRO439LEU	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0008	Disease	p.VAL262MET	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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