Results for the protein: P42345

Results for the Protein: P42345

1169735

2475

MTOR

NCBI, UniProt

MTOR_HUMAN RecName: Full=Serine/threonine-protein kinase mTOR; AltName: Full=FK506-binding protein 12-rapamycin complex-associated protein 1; AltName: Full=FKBP12-rapamycin complex-associated protein; AltName: Full=Mammalian target of rapamycin; Short=mTOR; AltName: Full=Mechanistic target of rapamycin; AltName: Full=Rapamycin and FKBP12 target 1; AltName: Full=Rapamycin target protein 1

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Default View: TEL1 - COG5032 DUF3385 - pfam11865 FAT - pfam02259 Rapamycin_bind - pfam08771 PI3Kc_III - cd00896 PI3Kc - cd00891 PIKKc_ATM - cd05171 PIKKc_SMG1 - cd05170 PIKKc_DNA-PK - cd05172 PI3Kc_like - cd00142 PIKKc - cd05164 TRRAP - cd05163 PIKKc_TOR - cd05169 PIKKc_ATR - cd00892 PI3_PI4_kinase - pfam00454 PI3Kc - smart00146 FATC - pfam02260	Swiss-Prot Protein: P42345 Identical to: NP_004949 Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PI3Kc	cd00891	7.9e-06	2086	2441
PI3Kc_like	cd00142	1e-121	2153	2424
PIKKc_ATR	cd00892	8.2e-80	2153	2431
PIKKc	cd05164	6.1e-163	2153	2424
TRRAP	cd05163	8.9e-09	2153	2431
PIKKc_TOR	cd05169	2.3e-219	2153	2431
PIKKc_DNA-PK	cd05172	2.5e-44	2153	2431
PIKKc_SMG1	cd05170	8.9e-57	2153	2431
PIKKc_ATM	cd05171	1.6e-46	2153	2431
TEL1	COG5032		309	2549
FAT	pfam02259	8.8e-180	1513	1908
PI3_PI4_kinase	pfam00454	3.1e-109	2181	2431
FATC	pfam02260	2.2e-19	2517	2549
DUF3385	pfam11865	2.2e-91	854	1024
Rapamycin_bind	pfam08771	1.9e-70	2015	2114
PI3Kc	smart00146	1.1e-110	2183	2438

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041537	Polymorphism	p.ALA8SER	N/A
Swiss-Prot	VAR_041540	Polymorphism	p.ALA1134VAL	N/A
Swiss-Prot	VAR_064733	Polymorphism	p.LEU2220PHE	N/A
Swiss-Prot	VAR_041538	Polymorphism	p.MET135THR	N/A
Swiss-Prot	VAR_041539	Polymorphism	p.MET1083VAL	N/A
Swiss-Prot	VAR_041542	Polymorphism	p.MET2011VAL	N/A
Swiss-Prot	VAR_041544	Polymorphism	p.PRO2476LEU	N/A
Swiss-Prot	VAR_041541	Polymorphism	p.SER1178PHE	N/A
Swiss-Prot	VAR_041543	Polymorphism	p.SER2215TYR	N/A
Swiss-Prot	VAR_064734	Polymorphism	p.VAL2406ALA	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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