Results for the protein: P06241

Results for the Protein: P06241

125370

2534

FYN

NCBI, UniProt

FYN_HUMAN RecName: Full=Tyrosine-protein kinase Fyn; AltName: Full=Proto-oncogene Syn; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=Src-like kinase; Short=SLK; AltName: Full=p59-Fyn

			0 4 0 0 4

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Swiss-Prot Protein: P06241

Identical to: NP_002028

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_Kit	cd05104	2.9e-15	120	524
SH2	cd00173	1.1e-40	148	246
PTKc_VEGFR	cd05054	1.6e-20	165	527
PTKc_CSF-1R	cd05106	5.3e-27	218	525
PTKc_PDGFR	cd05055	1.5e-20	221	524
PTKc_PDGFR_beta	cd05107	4.1e-10	221	525
PTKc_PDGFR_alpha	cd05105	4.6e-15	231	526
STKc_myosinIIIB	cd06639	2.3e-05	243	526
STKc_TAO1	cd06635	2.5e-05	245	537
PTK_Tyk2_rpt1	cd05076	3.2e-05	246	521
STKc_PAK4	cd06657	0.00077	246	537
STKc_PAK5	cd06658	0.00035	246	532
STKc_PAK6	cd06659	1.4e-05	246	536
STKc_TAO3	cd06633	0.00079	247	537
STKc_PAK_II	cd06648	7.4e-07	247	524
STKc_myosinIIIA	cd06638	9.2e-07	250	520
STKc_p38alpha_MAPK14	cd07877	0.00032	251	533
STKc_STK10_LOK	cd06644	1.6e-05	252	537
PTKc_FGFR1	cd05098	1.1e-40	253	531
STKc_PAK	cd06614	4e-15	253	528
STKc_p38	cd07851	1.7e-06	253	533
STKc_PAK_I	cd06647	3.9e-05	254	525
STKc_PAK1	cd06654	0.00022	254	534
STKc_PAK2	cd06655	9.4e-05	254	535
STKc_PAK3	cd06656	7.6e-05	254	535
PTKc_FGFR2	cd05101	2.7e-36	255	531
STKc_TAO	cd06607	3.8e-06	255	537
STKc_TAO2	cd06634	5.5e-06	255	537
STKc_MAP4K3	cd06645	9.2e-07	255	524
STKc_MAP4K4_6	cd06636	1.6e-05	257	520
PTKc_FGFR	cd05053	2.4e-51	258	525
PTKc_FGFR4	cd05099	2.7e-44	258	534
PTKc_FGFR3	cd05100	2.3e-28	258	536
PKc_MKK7	cd06618	5.2e-09	260	537
STKc_p38beta_MAPK11	cd07878	0.00048	260	533
STKc_MAP4K5	cd06646	2.3e-06	261	521
STKc_CDK9	cd07865	5.5e-08	262	524
PTKc_EGFR_like	cd05057	1.4e-58	263	535
PTKc_VEGFR3	cd05102	1.9e-19	263	527
PTKc_VEGFR2	cd05103	3.7e-16	263	527
STKc_Sty1_Hog1	cd07856	2.7e-05	263	535
STKc_BUR1	cd07866	2.4e-09	263	513
PTKc_InsR_like	cd05032	5.4e-64	264	522
PTKc_Src_like	cd05034	6.5e-228	264	523
PTKc_ALK_LTK	cd05036	1.9e-66	264	522
PTKc_Csk_like	cd05039	1.6e-86	264	523
PTKc_Abl	cd05052	1.5e-106	264	524
PTKc_FAK	cd05056	2e-75	264	528
PTKc_InsR	cd05061	4.2e-48	264	533
PTKc_IGF-1R	cd05062	9.4e-49	264	521
PTKc_Lck_Blk	cd05067	8.8e-170	264	523
PTKc_Frk_like	cd05068	4e-161	264	523
PTKc_Yes	cd05069	1.5e-216	264	523
PTKc_Fyn_Yrk	cd05070	1.2e-236	264	523
PTKc_Src	cd05071	7.7e-211	264	525
PTKc_Lyn	cd05072	2e-165	264	523
PTKc_Hck	cd05073	3.6e-171	264	523
PTKc_Csk	cd05082	2.7e-80	264	523
PTKc_Chk	cd05083	1.2e-77	264	523
PTKc_EGFR	cd05108	2.4e-26	264	533
PTKc_HER4	cd05110	1.8e-36	264	537
PTKc_HER2	cd05109	2.4e-45	264	536
PTKc_Srm_Brk	cd05148	5.7e-139	264	523
STKc_ASK	cd06624	2.6e-07	264	525
STKc_TNIK	cd06637	1.1e-06	264	520
STKc_ERK1_2_like	cd07849	4.1e-06	264	536
STKc_CDK12	cd07864	3.3e-10	264	535
PTK_CCK4	cd05046	6.4e-35	265	522
PTKc_Ror	cd05048	9.4e-49	265	523
PTKc_Trk	cd05049	9.3e-51	265	529
PTKc_Musk	cd05050	5.5e-51	265	522
PTKc_DDR	cd05051	1e-40	265	522
PTKc_EphR_A2	cd05063	1.6e-76	265	524
PTKc_EphR_A10	cd05064	1.4e-60	265	524
PTKc_Ror1	cd05090	1.9e-45	265	523
PTKc_Ror2	cd05091	3.1e-39	265	523
PTKc_TrkA	cd05092	6.6e-46	265	522
PTKc_TrkB	cd05093	1.7e-38	265	533
PTKc_TrkC	cd05094	1.2e-25	265	533
PTKc_DDR2	cd05095	1.8e-44	265	522
PTKc_DDR1	cd05096	1e-36	265	522
PTKc_DDR_like	cd05097	4.1e-48	265	522
PTK_HER3	cd05111	1.1e-37	265	535
STKc_SLK_like	cd06611	4.3e-08	265	528
PKc_MAPKK_Byr1_like	cd06620	1.8e-08	265	530
STKc_SLK	cd06643	1e-05	265	537
PKc_MEK2	cd06649	0.00021	265	537
PTKc_EphR	cd05033	6.4e-94	266	524
PTKc_Jak_rpt2	cd05038	3.8e-49	266	524
PTK_Ryk	cd05043	9.9e-24	266	527
PTKc_Tec_like	cd05059	3.7e-109	266	521
PTKc_EphR_B	cd05065	2.1e-75	266	524
PTKc_EphR_A	cd05066	6.1e-78	266	524
PTKc_Jak1_rpt2	cd05079	2.3e-37	266	524
PTKc_Tie2	cd05088	1.2e-23	266	537
PTKc_Itk	cd05112	5.7e-94	266	521
PTKc_Tec_Rlk	cd05114	8.5e-93	266	521
PTKc_Btk_Bmx	cd05113	2.4e-94	266	521
STKc_MAPK15	cd07852	5.1e-05	266	536
STKc_myosinIII_like	cd06608	1.9e-09	267	520
STKc_MST1_2	cd06612	8.9e-13	267	520
STKc_MAP4K3_like	cd06613	9.8e-13	267	524
STKc_MST4	cd06640	5.3e-08	267	535
STKc_MST3	cd06641	1.6e-07	267	535
STKc_STK25-YSK1	cd06642	1.7e-08	267	535
STKc_PCTAIRE_like	cd07844	2.2e-07	267	535
STKc_PFTAIRE2	cd07870	2.7e-06	267	535
PKc_MKK4	cd06616	6.6e-08	268	537
STKc_MEKK2	cd06652	7.2e-05	268	526
STKc_MEKK3_like_1	cd06653	1.1e-06	268	525
STKc_PFTAIRE1	cd07869	0.00015	268	536
STKc_Nek6_Nek7	cd08224	5.1e-09	268	525
PTKc_Tie1	cd05089	3.7e-31	269	530
STKc_ROCK_NDR_like	cd05573	9.7e-05	269	536
STKc_phototropin_lik	cd05574	3.3e-07	269	528
STKc_PKA	cd05580	3.3e-06	269	523
STKc_PDK1	cd05581	4.4e-11	269	525
STKc_PRKX_like	cd05612	0.00035	269	532
PKc_MAPKK	cd06605	3.4e-11	269	521
STKc_MST3_like	cd06609	4.2e-10	269	535
STKc_OSR1_SPAK	cd06610	6.6e-13	269	520
PKc_MEK	cd06615	2.7e-07	269	537
PKc_MKK3_6	cd06617	1.6e-09	269	537
PKc_MKK5	cd06619	0.00012	269	531
PKc_MAPKK_Pek1_like	cd06621	9.2e-08	269	523
PKc_MAPKK_PBS2_like	cd06622	2.2e-07	269	533
PKc_MAPKK_plant_like	cd06623	2.9e-14	269	526
STKc_CDKL	cd07833	1.9e-07	269	524
STKc_CdkB_plant	cd07837	2.6e-08	269	525
STKc_CDC2L1	cd07843	3e-08	269	524
STKc_CDK10	cd07845	8.3e-08	269	535
STKc_CDKL2_3	cd07846	5.7e-08	269	524
STKc_CDKL1_4	cd07847	1.3e-06	269	524
STKc_CDK6	cd07862	0.00027	269	531
STKc_PCTAIRE3	cd07871	4.3e-06	269	524
STKc_PCTAIRE2	cd07872	3.6e-05	269	537
STKc_PCTAIRE1	cd07873	5.9e-05	269	528
PK_STRAD	cd08216	1.2e-05	269	526
STKc_Nek6	cd08228	4.2e-07	269	525
STKc_Nek7	cd08229	2.7e-09	269	525
SPS1	COG0515	2.8e-12	269	536
PTKc_RET	cd05045	2.8e-47	270	527
PKc_STE	cd05122	4e-19	270	524
STKc_MSK_N	cd05583	3.5e-06	270	533
STKc_cPKC	cd05587	5.8e-05	270	536
STKc_GRK4_like	cd05605	5.4e-07	270	535
STKc_MSK1_N	cd05613	0.00091	270	533
STKc_cPKC_alpha	cd05615	7e-05	270	537
STKc_cPKC_beta	cd05616	0.00045	270	536
STKc_GRK6	cd05630	4.2e-05	270	535
STKc_GRK4	cd05631	0.00014	270	535
STKc_GRK5	cd05632	1.5e-05	270	535
STKc_MAPKKK	cd06606	1.1e-21	270	520
STKc_Cdc7_like	cd06627	6.9e-18	270	520
STKc_MEKK3	cd06651	4.1e-08	270	527
STKc_CCRK	cd07832	1.7e-10	270	525
STKc_MAPK	cd07834	2.6e-08	270	537
STKc_Pho85	cd07836	2.2e-06	270	535
STKc_CDK5	cd07839	3.9e-07	270	524
STKc_CDK7	cd07841	1.2e-11	270	533
STKc_CDK8_like	cd07842	2.4e-05	270	524
STKc_NLK	cd07853	0.00066	270	531
STKc_MPK1	cd07857	1.1e-05	270	528
STKc_CDK2_3	cd07860	1e-05	270	532
STKc_CDK1_euk	cd07861	7.8e-05	270	535
STKc_CDK4	cd07863	0.00018	270	524
STKc_Nek2	cd08217	3.5e-09	270	520
STKc_Nek1	cd08218	8.3e-12	270	525
STKc_Nek	cd08215	7e-16	270	520
STKc_Nek8	cd08220	1.6e-06	270	520
STKc_Nek11	cd08222	3.9e-09	270	520
STKc_Nek4	cd08223	1.3e-09	270	520
STKc_Nek5	cd08225	8.8e-17	270	520
STKc_Nek3	cd08219	4.4e-12	270	520
STKc_Nek10	cd08528	9e-06	270	522
STKc_CNK2-like	cd08530	3e-08	270	521
PTKc_Axl_like	cd05035	1.3e-46	271	524
PTKc_Tyro3	cd05074	7.5e-43	271	524
PTKc_Axl	cd05075	1.4e-41	271	524
PTKc_Tyk2_rpt2	cd05080	1.1e-27	271	525
PTKc_Jak2_Jak3_rpt2	cd05081	5.4e-40	271	524
STKc_CMGC	cd05118	1.4e-12	271	524
STKc_PKN	cd05589	1.8e-05	271	537
STKc_CDK_like	cd07829	1.5e-13	271	524
STKc_MAK_like	cd07830	1.3e-14	271	524
STKc_MOK	cd07831	2e-07	271	524
STKc_CDK1_like	cd07835	5.5e-06	271	535
STKc_CDK4_6_like	cd07838	9.2e-06	271	516
STKc_CDK9_like	cd07840	2e-13	271	524
STKc_Yank1	cd05578	9.6e-09	272	525
STKc_MEKK4	cd06626	1.1e-11	272	525
STKc_MAPKKK_Byr2_lik	cd06628	9.9e-17	272	520
STKc_MAPKKK_Bck1_lik	cd06629	8.8e-10	272	520
STKc_MEKK3_like	cd06625	1.5e-10	272	525
STKc_NAK1_like	cd06917	8.1e-09	272	528
STKc_CRIK	cd05601	0.00016	273	537
STKc_MAPK4_6	cd07854	2.5e-05	274	537
STKc_Nek9	cd08221	1.5e-08	274	521
STKc_FA2-like	cd08529	5.5e-12	274	520
PTKc	cd00192	3.5e-125	275	521
PTK_Jak_rpt1	cd05037	2.6e-11	275	521
PTKc_Ack_like	cd05040	2.9e-66	275	522
PTKc_Aatyk	cd05042	1.7e-16	275	519
PTKc_c-ros	cd05044	3.5e-65	275	522
PTKc_Fes_like	cd05041	1.2e-90	275	522
PTKc_Tie	cd05047	1.4e-36	275	525
PTKc_Met_Ron	cd05058	2.1e-56	275	526
PTKc_Syk_like	cd05060	9.7e-71	275	525
PTK_Jak1_rpt1	cd05077	6.2e-09	275	521
PTK_Jak2_Jak3_rpt1	cd05078	4.2e-10	275	521
PTKc_Fes	cd05084	7.4e-69	275	522
PTKc_Fer	cd05085	7.9e-77	275	522
PTKc_Aatyk2	cd05086	3e-18	275	522
PTKc_Aatyk1_Aatyk3	cd05087	3.9e-20	275	522
PTKc_Syk	cd05116	1.8e-55	275	525
STKc_PKC	cd05570	1e-06	275	537
STKc_nPKC_epsilon	cd05591	0.00037	275	536
STKc_nPKC_theta_delt	cd05592	0.00049	275	537
STKc_nPKC_theta	cd05619	4.1e-05	275	537
STKc_MEKK1	cd06630	6.4e-07	275	525
STKc_MEKK1_plant	cd06632	9.5e-12	275	520
PTKc_Zap-70	cd05115	5.2e-56	276	525
PKc	cd00180	1e-68	277	519
STKc_AGC	cd05123	4.8e-10	277	524
STKc_cGK_PKG	cd05572	1.3e-07	277	523
STKc_GRK	cd05577	9.4e-07	277	534
STKc_MAST_like	cd05579	1.3e-08	277	525
STKc_GRK7	cd05607	2.2e-05	277	534
STKc_GRK1	cd05608	4e-05	277	534
STKc_YSK4	cd06631	3.8e-09	277	520
SH3_1	pfam00018	2.4e-24	88	135
SH2	pfam00017	4.1e-44	149	231
Pkinase	pfam00069	6.6e-46	271	520
SH3	smart00326	6.1e-25	83	141
SH3_2	pfam07653	5.5e-11	86	140
SH2	smart00252	3.4e-34	147	237
Pkinase_Tyr	pfam07714	2.9e-152	271	520
STYKc	smart00221	1.5e-56	271	504
TyrKc	smart00219	1e-131	271	520
S_TKc	smart00220	3e-54	281	524
KIND	smart00750	0.0007	348	530

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041706	Polymorphism	p.ASP506GLU	N/A
Swiss-Prot	VAR_041705	Polymorphism	p.GLY410ARG	N/A
Swiss-Prot	VAR_014661	Polymorphism	p.ILE445PHE	N/A
Swiss-Prot	VAR_041704	Polymorphism	p.VAL243LEU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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