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Results for the Protein: P06239
125474
LCK

LCK_HUMAN RecName: Full=Tyrosine-protein kinase Lck; AltName: Full=Leukocyte C-terminal Src kinase; Short=LSK; AltName: Full=Lymphocyte cell-specific protein-tyrosine kinase; AltName: Full=Protein YT16; AltName: Full=Proto-oncogene Lck; AltName: Full=T cell-specific protein-tyrosine kinase; AltName: Full=p56-LCK
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SH3 - smart00326
SH3 - cd00174
SH3_2 - pfam07653
SH3_1 - pfam00018
PTKc_VEGFR - cd05054
SH2 - smart00252
SH2 - cd00173
SH2 - pfam00017
PTKc_PDGFR_beta - cd05107
PTKc_Kit - cd05104
PTKc_CSF-1R - cd05106
PTKc_PDGFR_alpha - cd05105
PTK_Tyk2_rpt1 - cd05076
STKc_TAO1 - cd06635
PTKc_PDGFR - cd05055
STKc_PAK5 - cd06658
PTKc_FGFR1 - cd05098
STKc_PAK6 - cd06659
PTKc_FGFR2 - cd05101
STKc_myosinIIIA - cd06638
STKc_myosinIIIB - cd06639
STKc_CDK9 - cd07865
STKc_MAP4K4_6 - cd06636
STKc_ASK - cd06624
PTKc_FGFR4 - cd05099
STKc_p38 - cd07851
STKc_PAK2 - cd06655
STKc_MAP4K5 - cd06646
STKc_PAK3 - cd06656
PKc_MKK7 - cd06618
STKc_PAK - cd06614
PTKc_FGFR3 - cd05100
STKc_PAK_II - cd06648
STKc_MAP4K3 - cd06645
STKc_PAK_I - cd06647
PTKc_FGFR - cd05053
STKc_TAO - cd06607
PTKc_VEGFR2 - cd05103
PTKc_EGFR_like - cd05057
STKc_TAO2 - cd06634
PTKc_VEGFR3 - cd05102
PTKc_Lck_Blk - cd05067
PTKc_HER4 - cd05110
PTKc_HER2 - cd05109
PTKc_EGFR - cd05108
STKc_CDK12 - cd07864
PTKc_Chk - cd05083
STKc_ERK1_2_like - cd07849
STKc_TNIK - cd06637
PTKc_Srm_Brk - cd05148
STKc_PFTAIRE2 - cd07870
PTKc_FAK - cd05056
PTKc_InsR_like - cd05032
PTKc_Abl - cd05052
PTKc_Csk_like - cd05039
PTKc_ALK_LTK - cd05036
PTKc_Src_like - cd05034
PTKc_InsR - cd05061
PTKc_Csk - cd05082
PTKc_Src - cd05071
PTKc_IGF-1R - cd05062
PTKc_Hck - cd05073
PTKc_Fyn_Yrk - cd05070
PTKc_Lyn - cd05072
PTKc_Yes - cd05069
PTKc_Frk_like - cd05068
PTKc_DDR_like - cd05097
PTKc_DDR1 - cd05096
PKc_MAPKK_Byr1_like - cd06620
STKc_SLK - cd06643
PTKc_DDR2 - cd05095
STKc_SLK_like - cd06611
PTKc_Ror2 - cd05091
PTKc_Musk - cd05050
PTKc_TrkC - cd05094
PTKc_Trk - cd05049
PTKc_Ror - cd05048
PTK_CCK4 - cd05046
PTKc_EphR_A2 - cd05063
PTKc_DDR - cd05051
PTKc_EphR_A10 - cd05064
PTKc_TrkA - cd05092
PTKc_TrkB - cd05093
PTKc_Ror1 - cd05090
STKc_Sty1_Hog1 - cd07856
PTKc_Tec_Rlk - cd05114
STKc_BUR1 - cd07866
PTKc_Btk_Bmx - cd05113
STKc_MAPK15 - cd07852
PTKc_Tie2 - cd05088
PTK_Ryk - cd05043
PTKc_Jak_rpt2 - cd05038
PTKc_EphR_B - cd05065
PTKc_EphR - cd05033
PTKc_Itk - cd05112
PTKc_Tec_like - cd05059
PTK_HER3 - cd05111
PTKc_Jak1_rpt2 - cd05079
PTKc_EphR_A - cd05066
STKc_PCTAIRE_like - cd07844
STKc_MST3 - cd06641
STKc_MST1_2 - cd06612
STKc_myosinIII_like - cd06608
STKc_MAP4K3_like - cd06613
STKc_MST4 - cd06640
STKc_STK25-YSK1 - cd06642
STKc_STK10_LOK - cd06644
STKc_PFTAIRE1 - cd07869
PKc_MKK4 - cd06616
STKc_Nek6_Nek7 - cd08224
STKc_MEKK2 - cd06652
STKc_MEKK3_like_1 - cd06653
STKc_CDKL1_4 - cd07847
STKc_PCTAIRE3 - cd07871
STKc_CDC2L1 - cd07843
STKc_PCTAIRE2 - cd07872
STKc_CDKL2_3 - cd07846
STKc_Nek7 - cd08229
SPS1 - COG0515
STKc_CdkB_plant - cd07837
STKc_Nek6 - cd08228
STKc_PCTAIRE1 - cd07873
STKc_MST3_like - cd06609
STKc_CDKL - cd07833
PKc_MAPKK - cd06605
STKc_PRKX_like - cd05612
STKc_PDK1 - cd05581
PTKc_Tie1 - cd05089
STKc_phototropin_lik - cd05574
PKc_MEK - cd06615
STKc_PKA - cd05580
STKc_NAK1_like - cd06917
PKc_MKK3_6 - cd06617
PKc_MAPKK_plant_like - cd06623
STKc_OSR1_SPAK - cd06610
PKc_MAPKK_PBS2_like - cd06622
PKc_MKK5 - cd06619
PKc_MAPKK_Pek1_like - cd06621
STKc_Nek - cd08215
STKc_Nek1 - cd08218
STKc_CDK4 - cd07863
STKc_CDK1_euk - cd07861
STKc_CDK2_3 - cd07860
STKc_Nek3 - cd08219
STKc_Nek10 - cd08528
STKc_MPK1 - cd07857
STKc_CNK2-like - cd08530
STKc_Nek5 - cd08225
STKc_Nek4 - cd08223
STKc_Nek8 - cd08220
STKc_CDK7 - cd07841
STKc_cPKC_alpha - cd05615
STKc_GRK6 - cd05630
STKc_CDK8_like - cd07842
STKc_GRK4_like - cd05605
STKc_MSK_N - cd05583
PTKc_RET - cd05045
PKc_STE - cd05122
STKc_GRK5 - cd05632
STKc_GRK4 - cd05631
STKc_Cdc7_like - cd06627
STKc_MAPK - cd07834
STKc_Pho85 - cd07836
STKc_CDK5 - cd07839
STKc_MAPKKK - cd06606
STKc_CCRK - cd07832
STKc_MEKK3 - cd06651
STKc_CDK4_6_like - cd07838
STKc_CDK1_like - cd07835
STYKc - smart00221
TyrKc - smart00219
Pkinase - pfam00069
Pkinase_Tyr - pfam07714
STKc_CDK9_like - cd07840
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Axl - cd05075
PTKc_Tyk2_rpt2 - cd05080
STKc_CMGC - cd05118
STKc_PKN - cd05589
STKc_MOK - cd07831
STKc_CDK_like - cd07829
STKc_MAPKKK_Bck1_lik - cd06629
PTKc_Tyro3 - cd05074
PTKc_Axl_like - cd05035
STKc_MAK_like - cd07830
PK_STRAD - cd08216
STKc_MAPKKK_Byr2_lik - cd06628
STKc_Yank1 - cd05578
STKc_Nek2 - cd08217
STKc_MEKK3_like - cd06625
STKc_CDK10 - cd07845
STKc_FA2-like - cd08529
STKc_Nek11 - cd08222
STKc_MAPK4_6 - cd07854
STKc_RSK_N - cd05582
PTKc_Zap-70 - cd05115
STKc_PKC - cd05570
STKc_nPKC_theta - cd05619
STKc_MEKK1_plant - cd06632
PTKc_Syk - cd05116
STKc_YSK4 - cd06631
STKc_MEKK1 - cd06630
PTKc_Aatyk2 - cd05086
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Tie - cd05047
PTKc_Fer - cd05085
PTKc_Met_Ron - cd05058
PTKc_Ack_like - cd05040
PTKc_Fes_like - cd05041
PTK_Jak_rpt1 - cd05037
PTKc_Fes - cd05084
PTKc_Aatyk1_Aatyk3 - cd05087
PTK_Jak2_Jak3_rpt1 - cd05078
PTK_Jak1_rpt1 - cd05077
PTKc_Syk_like - cd05060
PTKc - cd00192
STKc_MEKK4 - cd06626
STKc_GRK1 - cd05608
STKc_cGK_PKG - cd05572
STKc_AGC - cd05123
PKc - cd00180
STKc_Nek9 - cd08221
STKc_GRK - cd05577
STKc_beta_ARK - cd05606
STKc_GRK7 - cd05607
STKc_MAST_like - cd05579
S_TKc - smart00220


Swiss-Prot Protein: P06239
Identical to: NP_005347, NP_001036236
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
SH3cd001741.6e-1765118
PTKc_VEGFRcd050548.1e-2896501
SH2cd001734.4e-40126224
PTKc_Kitcd051041.2e-17203498
PTKc_CSF-1Rcd051062.4e-34203499
PTKc_PDGFR_betacd051072.2e-14203499
PTKc_PDGFR_alphacd051051.2e-16206500
PTK_Tyk2_rpt1cd050763.3e-06212498
STKc_TAO1cd066350.00088218508
PTKc_PDGFRcd050554.1e-23222498
STKc_PAK5cd066580.00087222506
PTKc_FGFR1cd050985.7e-49224505
STKc_PAK6cd066591.4e-05224497
PTKc_FGFR2cd051019.1e-47225505
STKc_myosinIIIAcd066382.8e-06226498
STKc_myosinIIIBcd066390.00021226500
STKc_CDK9cd078654.3e-07227498
STKc_MAP4K4_6cd066368e-05228499
PTKc_FGFR4cd050998.2e-54234508
STKc_ASKcd066241.6e-09234499
PTKc_FGFR3cd051008.8e-35235509
STKc_PAKcd066145.2e-13235508
PKc_MKK7cd066186.1e-07235504
STKc_MAP4K3cd066451.6e-05235498
STKc_MAP4K5cd066468.4e-06235495
STKc_PAK_IIcd066487.7e-07235498
STKc_PAK3cd066560.0008235509
STKc_PAK2cd066550.0008235508
STKc_p38cd078511e-05235507
PTKc_FGFRcd050531.5e-66236499
STKc_PAK_Icd066470.00093236506
PTKc_EGFR_likecd050572.7e-59237502
PTKc_VEGFR3cd051022.6e-30237501
PTKc_VEGFR2cd051031.1e-26237501
STKc_TAOcd066070.00017237506
STKc_TAO2cd066340.00021237509
PTKc_InsR_likecd050324.5e-74238496
PTKc_ALK_LTKcd050361.1e-65238499
PTKc_Src_likecd050341.7e-215238497
PTKc_Csk_likecd050399.1e-93238497
PTKc_Ablcd050521.7e-109238498
PTKc_FAKcd050563.2e-80238502
PTKc_InsRcd050611.1e-49238503
PTKc_IGF-1Rcd050624.1e-56238496
PTKc_Frk_likecd050683.9e-147238497
PTKc_Yescd050691.9e-164238497
PTKc_Fyn_Yrkcd050707.1e-166238497
PTKc_Srccd050716.7e-160238499
PTKc_Lyncd050722.6e-182238497
PTKc_Hckcd050733.2e-188238497
PTKc_Cskcd050825.8e-83238497
PTKc_Chkcd050834.2e-83238497
PTKc_HER2cd051095.3e-40238508
PTKc_HER4cd051103.5e-31238506
PTKc_Lck_Blkcd050674.2e-206238497
PTKc_EGFRcd051083.3e-28238509
PTKc_Srm_Brkcd051482.7e-127238497
STKc_TNIKcd066379.7e-07238498
STKc_ERK1_2_likecd078491.4e-05238505
STKc_CDK12cd078641.1e-09238509
STKc_PFTAIRE2cd078704.6e-06238509
PTK_CCK4cd050461.3e-43239496
PTKc_Rorcd050481.3e-43239497
PTKc_Trkcd050492.1e-51239503
PTKc_Muskcd050501.6e-59239496
PTKc_DDRcd050511.1e-44239496
PTKc_EphR_A2cd050632.2e-73239498
PTKc_EphR_A10cd050641.1e-60239498
PTKc_Ror1cd050908.2e-42239497
PTKc_Ror2cd050912.7e-41239497
PTKc_TrkAcd050922.6e-48239496
PTKc_TrkBcd050932.6e-41239506
PTKc_TrkCcd050942.4e-24239506
PTKc_DDR2cd050951.2e-42239496
PTKc_DDR1cd050962.5e-33239496
PTKc_DDR_likecd050971.1e-42239496
PKc_MAPKK_Byr1_likecd066208.7e-06239504
STKc_SLK_likecd066113.6e-07239502
STKc_SLKcd066432.9e-05239503
PTKc_EphRcd050332.2e-94240498
PTKc_Jak_rpt2cd050383.3e-57240498
PTK_Rykcd050436.1e-25240501
PTKc_Tec_likecd050598.1e-111240495
PTKc_EphR_Bcd050657.3e-74240498
PTKc_EphR_Acd050666.1e-76240498
PTKc_Jak1_rpt2cd050791.9e-43240498
PTKc_Tie2cd050887.7e-32240505
PTK_HER3cd051117.2e-33240508
PTKc_Itkcd051129.7e-98240495
PTKc_Btk_Bmxcd051135.2e-96240495
PTKc_Tec_Rlkcd051143.8e-92240495
STKc_Sty1_Hog1cd078560.00054240501
STKc_MAPK15cd078523.6e-06240497
STKc_BUR1cd078661.4e-10240487
STKc_myosinIII_likecd066083.9e-07241498
STKc_MST1_2cd066124.1e-11241498
STKc_MAP4K3_likecd066133e-09241498
STKc_MST4cd066403.5e-07241509
STKc_MST3cd066411.7e-07241509
STKc_STK25-YSK1cd066425.5e-08241509
STKc_STK10_LOKcd066440.00027241507
STKc_PCTAIRE_likecd078447.5e-07241509
PKc_MKK4cd066162.1e-07242505
STKc_MEKK2cd066529.5e-06242500
STKc_MEKK3_like_1cd066538.6e-08242495
STKc_PFTAIRE1cd078690.00013242502
STKc_Nek6_Nek7cd082243e-09242499
PTKc_Tie1cd050893.7e-41243504
STKc_phototropin_likcd055743.5e-05243502
STKc_PKAcd055801.9e-05243490
STKc_PDK1cd055816.9e-11243498
STKc_PRKX_likecd056120.00011243506
PKc_MAPKKcd066055.3e-09243503
STKc_MST3_likecd066094.2e-11243509
PKc_MEKcd066151.2e-05243505
PKc_MKK3_6cd066172.6e-08243495
PKc_MKK5cd066190.00089243505
PKc_MAPKK_Pek1_likecd066212.6e-07243494
PKc_MAPKK_PBS2_likecd066224.3e-07243508
PKc_MAPKK_plant_likecd066234.1e-13243503
STKc_OSR1_SPAKcd066102e-12243498
STKc_NAK1_likecd069171.7e-09243502
STKc_CDKLcd078331e-06243498
STKc_CdkB_plantcd078371.4e-07243488
STKc_CDC2L1cd078433e-07243498
STKc_CDKL2_3cd078461.3e-07243498
STKc_CDKL1_4cd078479.3e-07243498
STKc_PCTAIRE3cd078717.1e-06243509
STKc_PCTAIRE2cd078720.00016243508
STKc_PCTAIRE1cd078730.00012243502
STKc_Nek6cd082284.3e-07243499
STKc_Nek7cd082293.9e-10243499
SPS1COG05158.3e-07243508
PTKc_RETcd050451.6e-59244501
PKc_STEcd051222e-14244498
STKc_MSK_Ncd055830.00038244507
STKc_GRK4_likecd056052.8e-06244509
STKc_cPKC_alphacd056150.00093244508
STKc_GRK6cd056300.00071244509
STKc_GRK4cd056310.00035244509
STKc_GRK5cd056325e-05244509
STKc_Cdc7_likecd066274.8e-16244487
STKc_MEKK3cd066511.2e-08244501
STKc_MAPKKKcd066065.4e-21244499
STKc_CCRKcd078327.9e-09244499
STKc_MAPKcd078341.5e-07244497
STKc_Pho85cd078369.5e-07244509
STKc_CDK7cd078412.5e-09244491
STKc_CDK5cd078392.8e-06244506
STKc_CDK8_likecd078422.9e-06244498
STKc_MPK1cd078573.5e-05244497
STKc_CDK2_3cd078602.8e-05244506
STKc_CDK1_eukcd078612.8e-05244509
STKc_CDK4cd078630.00039244506
STKc_Nekcd082151.3e-14244494
STKc_Nek1cd082183.7e-09244499
STKc_Nek3cd082199e-11244494
STKc_Nek8cd082203.5e-06244494
STKc_Nek4cd082237e-08244499
STKc_Nek5cd082251.2e-11244499
STKc_Nek10cd085281e-07244496
STKc_CNK2-likecd085303.1e-08244494
PTKc_Axl_likecd050354.5e-56245498
PTKc_Tyro3cd050747.5e-48245498
PTKc_Tyk2_rpt2cd050809.4e-31245499
PTKc_Axlcd050757.2e-45245498
PTKc_Jak2_Jak3_rpt2cd050815.6e-41245498
STKc_CMGCcd051181.5e-11245490
STKc_PKNcd055890.00021245506
STKc_MAPKKK_Bck1_likcd066299.4e-10245488
STKc_CDK_likecd078295.3e-14245490
STKc_MAK_likecd078304.8e-13245498
STKc_MOKcd078314.7e-06245498
STKc_CDK1_likecd078351.5e-06245509
STKc_CDK4_6_likecd078383.2e-07245490
STKc_CDK9_likecd078401.4e-13245498
STKc_Yank1cd055781.1e-06246499
STKc_MEKK3_likecd066251.1e-12246499
STKc_MAPKKK_Byr2_likcd066283.2e-18246498
STKc_CDK10cd078453.1e-07246488
PK_STRADcd082164.8e-05246500
STKc_Nek2cd082171.8e-09246495
STKc_FA2-likecd085292.6e-11246494
STKc_Nek11cd082221e-08247499
PTKc_Zap-70cd051156.6e-60248499
STKc_RSK_Ncd055820.00072248508
STKc_MAPK4_6cd078540.00017248509
PTKccd001921.3e-128249495
PTK_Jak_rpt1cd050377.7e-11249494
PTKc_Fes_likecd050411.1e-90249496
PTKc_Aatykcd050422.6e-13249496
PTKc_c-roscd050441.7e-64249496
PTKc_Tiecd050475.9e-46249499
PTKc_Ack_likecd050402.6e-72249496
PTKc_Met_Roncd050583.4e-57249500
PTKc_Syk_likecd050601e-79249499
PTK_Jak1_rpt1cd050772.2e-09249498
PTK_Jak2_Jak3_rpt1cd050783.8e-11249498
PTKc_Fescd050848.9e-71249496
PTKc_Aatyk1_Aatyk3cd050871.1e-14249496
PTKc_Aatyk2cd050863.5e-10249496
PTKc_Fercd050851.7e-72249496
PTKc_Sykcd051169.9e-63249499
STKc_PKCcd055707.6e-06249499
STKc_nPKC_thetacd056190.00051249507
STKc_MEKK1cd066302.5e-07249499
STKc_YSK4cd066312.3e-09249498
STKc_MEKK1_plantcd066323.5e-12249499
STKc_MEKK4cd066268e-11250499
PKccd001805.1e-68251494
STKc_AGCcd051233.6e-09251498
STKc_cGK_PKGcd055721.8e-07251491
STKc_GRKcd055770.00014251507
STKc_MAST_likecd055795.2e-07251489
STKc_GRK7cd056075e-06251508
STKc_GRK1cd056080.00019251508
STKc_beta_ARKcd056060.00075251509
STKc_Nek9cd082211.9e-06251499
SH3_1pfam000182.4e-1667113
SH2pfam000178.1e-43127209
Pkinasepfam000691.1e-41245494
SH3smart003263.1e-1762119
SH3_2pfam076533.4e-0865118
SH2smart002526.5e-35125215
Pkinase_Tyrpfam077146.3e-154245494
TyrKcsmart002192.3e-131245494
STYKcsmart002214e-54245496
S_TKcsmart002202e-52255498

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_013465Polymorphismp.ALA353VALN/A
Swiss-ProtVAR_051697Polymorphismp.GLY201SERN/A
Swiss-ProtVAR_013466Polymorphismp.PRO447LEUN/A
Swiss-ProtVAR_013463Polymorphismp.VAL28LEUN/A



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