Results for the protein: P07948

Results for the Protein: P07948

125480

4067

LYN

NCBI, UniProt

LYN_HUMAN RecName: Full=Tyrosine-protein kinase Lyn; AltName: Full=Lck/Yes-related novel protein tyrosine kinase; AltName: Full=V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; AltName: Full=p53Lyn; AltName: Full=p56Lyn

			0 1 0 0 1

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Swiss-Prot Protein: P07948

Identical to: NP_002341

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	2.2e-32	128	226
PTKc_CSF-1R	cd05106	3e-36	210	502
PTKc_PDGFR	cd05055	2.7e-29	211	501
PTKc_Kit	cd05104	2.7e-21	211	501
PTKc_PDGFR_beta	cd05107	1.1e-22	211	502
PTKc_PDGFR_alpha	cd05105	1.1e-16	219	503
PTKc_FGFR1	cd05098	4.7e-48	226	508
STKc_myosinIIIB	cd06639	0.0008	226	503
STKc_TAO	cd06607	3.1e-05	228	511
STKc_PAK	cd06614	1.5e-11	229	511
STKc_TAO1	cd06635	0.00017	229	511
STKc_myosinIIIA	cd06638	1.8e-06	229	498
PTKc_FGFR2	cd05101	2.6e-46	230	508
STKc_MAP4K4_6	cd06636	4.8e-05	230	497
STKc_p38gamma_MAPK12	cd07880	0.00044	232	512
PTKc_FGFR	cd05053	2.3e-61	234	502
PTKc_FGFR4	cd05099	5.2e-52	234	511
PTKc_FGFR3	cd05100	1.2e-30	234	511
STKc_STK10_LOK	cd06644	0.00011	235	508
PKc_MKK7	cd06618	3.8e-08	236	510
STKc_ASK	cd06624	1.7e-09	236	501
STKc_TAO2	cd06634	1.1e-05	236	511
STKc_p38	cd07851	1.6e-06	236	512
PTK_Tyk2_rpt1	cd05076	1.6e-06	237	498
STKc_PAK_II	cd06648	9.8e-07	237	501
STKc_PAK6	cd06659	2.1e-05	237	511
STKc_CDK9	cd07865	9.3e-07	238	501
PTKc_VEGFR	cd05054	1.9e-24	239	504
PTKc_EGFR_like	cd05057	2.3e-60	239	505
PTKc_VEGFR3	cd05102	2e-26	239	504
PTKc_VEGFR2	cd05103	7.1e-22	239	504
PTK_HER3	cd05111	7.1e-34	239	511
STKc_MAP4K3	cd06645	4.3e-07	239	497
STKc_Sty1_Hog1	cd07856	4.3e-05	239	510
STKc_PCTAIRE2	cd07872	4.3e-05	239	511
STKc_PCTAIRE1	cd07873	4e-05	239	505
PTKc_InsR_like	cd05032	2.1e-73	240	499
PTKc_Src_like	cd05034	9.8e-218	240	500
PTKc_ALK_LTK	cd05036	1.2e-65	240	499
PTKc_Csk_like	cd05039	1.8e-93	240	500
PTKc_Abl	cd05052	2.3e-109	240	501
PTKc_FAK	cd05056	8e-78	240	505
PTKc_InsR	cd05061	1.4e-53	240	508
PTKc_IGF-1R	cd05062	2.1e-55	240	499
PTKc_Lck_Blk	cd05067	2.6e-183	240	500
PTKc_Frk_like	cd05068	2.9e-153	240	500
PTKc_Yes	cd05069	7.9e-160	240	500
PTKc_Fyn_Yrk	cd05070	6.3e-163	240	500
PTKc_Src	cd05071	6e-157	240	502
PTKc_Lyn	cd05072	1.2e-232	240	500
PTKc_Hck	cd05073	9e-203	240	500
PTKc_Chk	cd05083	8.7e-79	240	500
PTKc_Csk	cd05082	2e-81	240	500
PTKc_EGFR	cd05108	6.7e-27	240	512
PTKc_HER2	cd05109	9.2e-37	240	511
PTKc_HER4	cd05110	1.3e-28	240	509
PTKc_Srm_Brk	cd05148	1e-125	240	500
STKc_TNIK	cd06637	4.4e-06	240	501
STKc_ERK1_2_like	cd07849	3.9e-05	240	510
STKc_CDK12	cd07864	8.6e-09	240	512
PTK_CCK4	cd05046	5.9e-36	241	499
PTKc_Ror	cd05048	6e-45	241	500
PTKc_Trk	cd05049	8.4e-49	241	506
PTKc_Musk	cd05050	1.2e-49	241	499
PTKc_DDR	cd05051	4.2e-34	241	495
PTKc_EphR_A2	cd05063	2e-75	241	501
PTKc_EphR_A10	cd05064	1.4e-62	241	501
PTKc_Ror1	cd05090	2e-43	241	500
PTKc_Ror2	cd05091	4.4e-38	241	500
PTKc_TrkA	cd05092	2.3e-52	241	499
PTKc_TrkB	cd05093	2.5e-43	241	509
PTKc_TrkC	cd05094	6.8e-32	241	509
PTKc_DDR2	cd05095	5.1e-39	241	499
PTKc_DDR1	cd05096	4.3e-30	241	499
PTKc_DDR_like	cd05097	5.1e-39	241	499
STKc_SLK_like	cd06611	1.1e-07	241	510
PKc_MAPKK_Byr1_like	cd06620	5.8e-06	241	501
STKc_SLK	cd06643	1.5e-05	241	512
STKc_MAP4K5	cd06646	8.6e-06	241	498
PTKc_EphR	cd05033	1.5e-93	242	501
PTKc_Jak_rpt2	cd05038	3.2e-62	242	501
PTK_Ryk	cd05043	2.4e-25	242	504
PTKc_Tec_like	cd05059	7.6e-109	242	498
PTKc_EphR_B	cd05065	9.8e-75	242	501
PTKc_EphR_A	cd05066	1.5e-77	242	501
PTKc_Jak1_rpt2	cd05079	4.4e-44	242	501
PTKc_Tie2	cd05088	2.3e-33	242	508
PTKc_Itk	cd05112	2.3e-96	242	498
PTKc_Btk_Bmx	cd05113	3e-95	242	498
PTKc_Tec_Rlk	cd05114	1.3e-92	242	498
STKc_BUR1	cd07866	1.9e-08	242	490
STKc_myosinIII_like	cd06608	4e-07	243	493
STKc_MST1_2	cd06612	2.7e-13	243	501
STKc_MAP4K3_like	cd06613	7.1e-11	243	498
STKc_MST4	cd06640	1.7e-07	243	504
STKc_MST3	cd06641	7.5e-08	243	512
STKc_STK25-YSK1	cd06642	2.1e-08	243	504
STKc_PCTAIRE_like	cd07844	7.5e-07	243	509
STKc_PFTAIRE2	cd07870	3.2e-06	243	512
PKc_MKK4	cd06616	9.3e-07	244	512
STKc_MEKK2	cd06652	1.6e-06	244	503
STKc_MEKK3_like_1	cd06653	3e-08	244	501
STKc_PCTAIRE3	cd07871	2.7e-05	244	509
STKc_Nek6_Nek7	cd08224	5.6e-10	244	502
PTKc_Tie1	cd05089	2.4e-38	245	507
STKc_ROCK_NDR_like	cd05573	5e-05	245	509
STKc_phototropin_lik	cd05574	7.4e-05	245	505
STKc_PKA	cd05580	1.7e-06	245	503
STKc_PRKX_like	cd05612	2.3e-06	245	509
PKc_MAPKK	cd06605	1.8e-09	245	498
STKc_MST3_like	cd06609	2.3e-11	245	512
STKc_OSR1_SPAK	cd06610	1.4e-12	245	497
PKc_MKK3_6	cd06617	5.2e-08	245	498
PKc_MKK5	cd06619	0.00049	245	511
PKc_MEK	cd06615	8.2e-06	245	512
PKc_MAPKK_Pek1_like	cd06621	3.1e-08	245	497
PKc_MAPKK_PBS2_like	cd06622	1.2e-06	245	511
PKc_MAPKK_plant_like	cd06623	1.2e-15	245	504
STKc_CDKL	cd07833	4.7e-06	245	493
STKc_CdkB_plant	cd07837	2.3e-07	245	510
STKc_CDK10	cd07845	1.3e-06	245	491
STKc_CDKL2_3	cd07846	6.9e-08	245	501
STKc_CDKL1_4	cd07847	3.1e-06	245	509
STKc_CDK6	cd07862	0.00066	245	509
STKc_Nek6	cd08228	2.9e-08	245	502
STKc_Nek7	cd08229	1.7e-10	245	502
STKc_FA2-like	cd08529	5.6e-11	245	497
SPS1	COG0515	1.9e-09	245	512
PTKc_RET	cd05045	1.3e-51	246	504
STKc_MSK_N	cd05583	0.00023	246	512
STKc_cPKC	cd05587	0.00023	246	510
STKc_GRK4_like	cd05605	2.6e-05	246	512
STKc_cPKC_alpha	cd05615	0.00019	246	510
STKc_GRK5	cd05632	0.00038	246	512
STKc_MAPKKK	cd06606	4.3e-32	246	493
STKc_Cdc7_like	cd06627	1.3e-18	246	490
STKc_MEKK3	cd06651	5.2e-09	246	503
STKc_MAPK	cd07834	5.1e-07	246	500
STKc_Pho85	cd07836	1.5e-06	246	512
STKc_CDK8_like	cd07842	2.2e-05	246	501
STKc_CDC2L1	cd07843	7.8e-06	246	501
STKc_MPK1	cd07857	2.4e-05	246	511
STKc_CDK2_3	cd07860	4.9e-06	246	509
STKc_CDK4	cd07863	0.00025	246	509
STKc_CDK1_euk	cd07861	5.5e-05	246	512
STKc_Nek	cd08215	2.4e-15	246	498
STKc_Nek1	cd08218	6.5e-09	246	502
STKc_Nek3	cd08219	2.3e-11	246	497
STKc_Nek8	cd08220	1.9e-06	246	497
STKc_Nek4	cd08223	1.3e-09	246	502
STKc_Nek5	cd08225	8.8e-14	246	502
STKc_Nek10	cd08528	9.3e-08	246	499
PTKc_Axl_like	cd05035	2e-53	247	501
PTKc_Tyro3	cd05074	1.1e-48	247	501
PTKc_Axl	cd05075	4.8e-47	247	501
PTKc_Jak2_Jak3_rpt2	cd05081	5.7e-46	247	501
PTKc_Tyk2_rpt2	cd05080	1.2e-34	247	502
STKc_PKN	cd05589	5.9e-05	247	509
STKc_MAPKKK_Bck1_lik	cd06629	4.7e-10	247	491
STKc_CDK1_like	cd07835	3e-06	247	509
STKc_CMGC	cd05118	1.6e-11	248	493
PKc_STE	cd05122	2.1e-15	248	492
STKc_PDK1	cd05581	7.9e-10	248	501
STKc_Yank1	cd05578	2.9e-09	248	502
STKc_MEKK3_like	cd06625	3.2e-13	248	499
STKc_MAPKKK_Byr2_lik	cd06628	7.9e-20	248	501
STKc_NAK1_like	cd06917	2e-10	248	505
STKc_CDK_like	cd07829	1e-13	248	502
STKc_MAK_like	cd07830	1e-12	248	500
STKc_MOK	cd07831	3e-06	248	490
STKc_CCRK	cd07832	1.3e-08	248	502
STKc_CDK4_6_like	cd07838	0.00015	248	493
STKc_CDK5	cd07839	1e-06	248	509
STKc_CDK7	cd07841	2.3e-09	248	494
STKc_CDK9_like	cd07840	3e-12	248	493
STKc_MAPK15	cd07852	2e-05	248	511
PK_STRAD	cd08216	0.00043	248	499
STKc_Nek2	cd08217	1.9e-09	248	496
STKc_CNK2-like	cd08530	3.6e-08	248	498
STKc_CRIK	cd05601	0.0002	249	509
STKc_Nek11	cd08222	4e-08	249	498
STKc_RSK_N	cd05582	0.00043	250	512
STKc_MAPK4_6	cd07854	7e-05	250	512
STKc_Nek9	cd08221	2.6e-07	250	502
PTKc	cd00192	2.4e-125	251	498
PTK_Jak_rpt1	cd05037	2.7e-10	251	498
PTKc_Ack_like	cd05040	3.5e-73	251	499
PTKc_Fes_like	cd05041	3.5e-85	251	499
PTKc_Aatyk	cd05042	4e-13	251	499
PTKc_c-ros	cd05044	4e-63	251	499
PTKc_Tie	cd05047	9.8e-45	251	502
PTKc_Met_Ron	cd05058	3.7e-62	251	503
PTKc_Syk_like	cd05060	4.3e-72	251	502
PTK_Jak1_rpt1	cd05077	4.9e-09	251	498
PTK_Jak2_Jak3_rpt1	cd05078	4.4e-09	251	498
PTKc_Fes	cd05084	2.5e-66	251	499
PTKc_Aatyk2	cd05086	1e-08	251	499
PTKc_Aatyk1_Aatyk3	cd05087	1.3e-19	251	499
PTKc_Fer	cd05085	2.8e-73	251	499
PTKc_Syk	cd05116	7.4e-56	251	502
STKc_PKC	cd05570	1.5e-06	251	502
STKc_nPKC_theta_delt	cd05592	0.00069	251	512
STKc_nPKC_theta	cd05619	8.4e-05	251	505
STKc_MEKK1	cd06630	5.8e-07	251	499
STKc_MEKK1_plant	cd06632	1.2e-12	251	496
PTKc_Zap-70	cd05115	5e-54	252	502
STKc_MEKK4	cd06626	1.6e-10	252	502
PKc	cd00180	1.1e-65	253	497
STKc_AGC	cd05123	5.4e-10	253	493
STKc_cGK_PKG	cd05572	4.1e-08	253	494
STKc_GRK	cd05577	7.4e-05	253	499
STKc_MAST_like	cd05579	9.7e-08	253	498
STKc_GRK7	cd05607	8.2e-05	253	511
STKc_GRK1	cd05608	0.00032	253	512
STKc_YSK4	cd06631	1.4e-11	253	501
SH3_1	pfam00018	1.8e-21	69	115
SH2	pfam00017	9.8e-41	129	211
Pkinase	pfam00069	1.6e-44	247	497
SH3	smart00326	2.5e-21	64	121
SH3_2	pfam07653	2.5e-05	67	120
SH2	smart00252	6.4e-33	127	217
Pkinase_Tyr	pfam07714	3.6e-152	247	497
TyrKc	smart00219	2.2e-133	247	497
STYKc	smart00221	1.1e-57	247	490
S_TKc	smart00220	1.8e-49	257	501

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041737	Polymorphism	p.ASP385TYR	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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