Results for the protein: P37231

Results for the Protein: P37231

13432234

5468

PPARG

NCBI, UniProt

PPARG_HUMAN RecName: Full=Peroxisome proliferator-activated receptor gamma; Short=PPAR-gamma; AltName: Full=Nuclear receptor subfamily 1 group C member 3

Known Diseases associated with this Protein:
  COLON CANCER, SOMATIC
  LIPODYSTROPHY, FAMILIAL PARTIAL, 3 (FPLD3)
  LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
  OBESITY (OBESITY)
  OBESITY, SEVERE

13

6

10

1

8

Tips:

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Swiss-Prot Protein: P37231

Identical to: NP_056953

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
NR_DBD_DHR4_like	cd07168	2.6e-31	128	219
NR_DBD_VDR	cd06955	5.9e-16	131	234
NR_DBD_PNR	cd06970	4.8e-25	131	220
NR_DBD_TLX	cd07163	7.1e-23	131	219
NR_DBD_GCNF_like	cd07169	5.5e-29	131	219
NR_DBD_ROR	cd06968	2e-33	132	225
NR_DBD_RAR	cd06964	5.2e-32	133	216
NR_DBD_ERR	cd07170	2.4e-20	133	229
NR_DBD_TR2_like	cd06967	1.8e-31	134	219
NR_DBD_REV_ERB	cd07166	1.1e-44	134	220
NR_DBD_ER	cd07171	1.7e-21	134	214
NR_DBD_AR	cd07173	2.6e-09	134	215
NR_DBD_GR_PR	cd07172	6.2e-09	135	211
NR_DBD_NGFI-B	cd06969	2.3e-32	137	210
NR_DBD_EcR_like	cd06959	3e-23	138	209
NR_DBD_TR	cd06961	2.1e-33	138	221
NR_DBD_Ppar	cd06965	1.2e-57	138	221
2DBD_NR_DBD1	cd07157	4.2e-14	138	219
NR_DBD_like	cd06916	1.8e-43	139	209
NR_DBD_PNR_like_2	cd06957	6e-23	139	218
NR_DBD_COUP_TF	cd06958	5.4e-25	139	210
NR_DBD_RXR	cd06956	9.4e-31	139	212
NR_DBD_HNF4A	cd06960	4.3e-31	139	213
NR_DBD_FXR	cd06962	1.6e-17	139	218
NR_DBD_GR_like	cd06963	1.9e-12	139	210
NR_DBD_CAR	cd06966	4.7e-13	139	229
NR_DBD_PNR_like	cd07154	4.2e-26	139	209
NR_DBD_ER_like	cd07155	2.1e-23	139	212
NR_DBD_VDR_like	cd07156	7.7e-25	139	209
NR_DBD_Ppar_like	cd07158	7.8e-47	139	209
NR_DBD_EcR	cd07161	1.8e-19	139	224
NR_DBD_PXR	cd07162	1.2e-20	139	227
NR_DBD_PNR_like_1	cd07164	1.3e-25	139	215
NR_DBD_DmE78_like	cd07165	4.3e-41	139	218
NR_DBD_Lrh-1_like	cd07167	9.1e-27	139	231
2DBD_NR_DBD2	cd07179	1.8e-32	139	211
NR_LBD_VDR	cd06933	2.1e-07	203	505
NR_LBD_PXR_like	cd06934	1.3e-05	236	500
NR_LBD_PPAR	cd06932	3.5e-176	237	504
NR_LBD_LXR	cd06954	2.4e-10	240	504
NR_LBD_ROR_like	cd06939	1e-10	251	505
NR_LBD_DHR38_like	cd07072	0.00047	252	505
NR_LBD_TR	cd06935	2.9e-07	255	500
NR_LBD_NGFI-B	cd07348	7.4e-05	261	505
NR_LBD_EcR	cd06938	4.7e-09	268	504
NR_LBD_Nurr1_like	cd06945	0.00041	268	505
NR_LBD_Ftz-F1_like	cd06944	0.00047	273	504
NR_LBD_HNF4_like	cd06931	3e-07	279	500
NR_LBD_ERR	cd06946	0.00031	280	503
NR_LBD_ER_like	cd07068	2.9e-06	281	503
NR_LBD_RAR	cd06937	2e-11	284	503
NR_LBD_RXR_like	cd06943	1.9e-08	284	482
NR_LBD_Fxr	cd06936	9.9e-09	286	499
NR_LBD_Tlx_PNR_like	cd06950	0.00026	287	490
NR_LBD_COUP-TF	cd06948	0.00041	290	500
NR_LBD_REV_ERB	cd06940	1.8e-27	296	486
NR_LBD_F1	cd06929	2.5e-67	307	481
NR_LBD_DmE78_like	cd06941	1.6e-24	309	502
NR_LBD_Sex_1_like	cd06942	1.2e-08	310	498
NR_LBD_F2	cd06930	2.1e-06	310	473
NR_LBD	cd06157	3e-44	311	473
zf-C4	pfam00105	1.1e-41	137	205
Hormone_recep	pfam00104	4.3e-33	341	500
PPARgamma_N	pfam12577	1.3e-08	67	108
ZnF_C4	smart00399	1.4e-35	138	206
HOLI	smart00430	1.9e-26	317	473

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_022701	Disease	p.ARG425CYS	Lipodystrophy, familial partial, 3 (FPLD3)
Swiss-Prot	VAR_010726	Polymorphism	p.ARG316HIS	N/A
Swiss-Prot	VAR_010725	Polymorphism	p.GLN314PRO	N/A
Swiss-Prot	VAR_022700	Disease	p.PHE388LEU	Lipodystrophy, familial partial, 3 (FPLD3)
dbSNP	rs1801282	Polymorphism	p.PRO12ALA	N/A
Swiss-Prot	VAR_016116	Polymorphism	p.PRO40ALA	N/A
Swiss-Prot	VAR_010724	Disease	p.PRO113GLN	Obesity (OBESITY)
Swiss-Prot	VAR_010728	Polymorphism	p.PRO495LEU	N/A
Swiss-Prot	VAR_010727	Polymorphism	p.VAL318MET	N/A
OMIM	601487.0013	Disease	p.ARG425CYS	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0006	Disease	p.ARG288HIS	COLON CANCER, SOMATIC
OMIM	601487.0015	Disease	p.ARG194TRP	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0014	Disease	p.CYS190SER	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0004	Disease	p.GLN286PRO	COLON CANCER, SOMATIC
OMIM	601487.0005	Disease	p.LYS319TER	COLON CANCER, SOMATIC
OMIM	601487.0012	Disease	p.PHE388LEU	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0001	Disease	p.PRO115GLN	OBESITY, SEVERE
OMIM	601487.0007	Disease	p.PRO467LEU	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3
OMIM	601487.0008	Disease	p.VAL290MET	LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 3

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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