Results for the protein: P29376

Results for the Protein: P29376

143811416

4058

LTK

NCBI, UniProt

LTK_HUMAN RecName: Full=Leukocyte tyrosine kinase receptor; AltName: Full=Protein tyrosine kinase 1; Flags: Precursor

			0 9 0 3 6

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Swiss-Prot Protein: P29376

Identical to: NP_002335

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_CSF-1R	cd05106	2.5e-32	464	782
PTKc_Kit	cd05104	3.5e-19	471	781
PTKc_PDGFR_alpha	cd05105	2.8e-15	471	793
PTKc_PDGFR_beta	cd05107	1.1e-09	471	782
PTKc_FGFR1	cd05098	1.1e-43	493	785
STKc_PAK_I	cd06647	0.00013	494	802
PTKc_FGFR2	cd05101	2e-44	495	784
PTKc_FGFR4	cd05099	2.8e-49	496	798
PTKc_DDR	cd05051	4.9e-43	497	779
STKc_PAK	cd06614	6.6e-08	497	794
PTKc_FGFR	cd05053	2.3e-58	498	782
PTKc_FGFR3	cd05100	9.8e-46	498	816
PKc_MKK7	cd06618	1.5e-06	498	793
STKc_PAK1	cd06654	0.00015	498	804
STKc_PAK2	cd06655	0.00038	498	805
STKc_PAK3	cd06656	6.5e-05	498	806
STKc_TAO	cd06607	0.00026	499	815
STKc_TAO2	cd06634	2.1e-05	499	822
STKc_CDK10	cd07845	0.00012	500	799
PTKc_PDGFR	cd05055	2.6e-20	502	781
PTKc_EGFR_like	cd05057	4.7e-49	502	788
PTKc_Tie2	cd05088	4.8e-32	502	802
PTKc_EGFR	cd05108	1.6e-33	502	817
PTKc_HER2	cd05109	9e-42	502	788
PTK_HER3	cd05111	1.6e-31	502	788
PTKc_HER4	cd05110	2.3e-28	502	803
STKc_PAK6	cd06659	3e-05	502	801
STKc_BUR1	cd07866	0.00016	502	798
PTKc_ALK_LTK	cd05036	1.9e-230	503	779
PTKc_FAK	cd05056	8.5e-62	503	785
STKc_ASK	cd06624	7.4e-07	503	779
STKc_STK10_LOK	cd06644	0.00061	503	798
STKc_PAK_II	cd06648	0.00032	503	791
STKc_CDK12	cd07864	2.5e-05	503	812
PTKc_InsR_like	cd05032	1.1e-100	504	779
PTKc_Src_like	cd05034	4.5e-64	504	779
PTKc_Csk_like	cd05039	1.5e-57	504	780
PTKc_Ror	cd05048	9.9e-74	504	780
PTK_CCK4	cd05046	8.9e-50	504	779
PTKc_Musk	cd05050	1.4e-75	504	779
PTKc_Abl	cd05052	1.7e-63	504	781
PTKc_InsR	cd05061	1.2e-81	504	790
PTKc_EphR_A2	cd05063	4.7e-53	504	778
PTKc_EphR_A10	cd05064	6.3e-53	504	781
PTKc_Trk	cd05049	1.4e-79	504	779
PTKc_Lck_Blk	cd05067	3.7e-46	504	777
PTKc_Frk_like	cd05068	3e-69	504	780
PTKc_Yes	cd05069	5.6e-46	504	780
PTKc_Src	cd05071	9.7e-47	504	781
PTKc_Lyn	cd05072	1.3e-46	504	777
PTKc_Hck	cd05073	5.2e-43	504	777
PTKc_Csk	cd05082	6.8e-54	504	780
PTKc_Fyn_Yrk	cd05070	5.2e-51	504	777
PTKc_Ror1	cd05090	1.9e-62	504	780
PTKc_Ror2	cd05091	3.8e-46	504	780
PTKc_TrkA	cd05092	7e-68	504	779
PTKc_TrkC	cd05094	1.7e-38	504	789
PTKc_DDR2	cd05095	2.7e-43	504	779
PTKc_DDR1	cd05096	9.7e-35	504	779
PTKc_DDR_like	cd05097	1.2e-45	504	779
PTKc_TrkB	cd05093	3.8e-61	504	789
PTKc_VEGFR3	cd05102	5e-37	504	784
PTKc_VEGFR2	cd05103	1.7e-25	504	784
PTKc_IGF-1R	cd05062	2.1e-85	504	779
STKc_MAP4K3	cd06645	0.00022	504	778
PTKc_EphR	cd05033	1.2e-60	505	781
PTKc_Jak_rpt2	cd05038	1.1e-38	505	781
PTK_Ryk	cd05043	8.6e-24	505	782
PTKc_Tec_like	cd05059	9.7e-59	505	778
PTKc_EphR_B	cd05065	4.4e-46	505	781
PTKc_EphR_A	cd05066	4.5e-52	505	781
PTKc_Jak1_rpt2	cd05079	7.3e-18	505	781
PTKc_Chk	cd05083	9.1e-65	505	780
PTKc_Itk	cd05112	3.1e-62	505	778
PTKc_Btk_Bmx	cd05113	5.6e-58	505	778
PTKc_Tec_Rlk	cd05114	9.8e-62	505	778
STKc_SLK_like	cd06611	4e-05	505	793
STKc_SLK	cd06643	0.00087	505	796
PKc_MKK4	cd06616	2.9e-05	506	791
STKc_MST4	cd06640	1.6e-05	506	791
STKc_MST3	cd06641	7e-06	506	791
STKc_STK25-YSK1	cd06642	5.3e-07	506	798
STKc_PCTAIRE_like	cd07844	0.00039	506	812
STKc_MAP4K3_like	cd06613	1.3e-07	507	778
STKc_MEKK3_like	cd06625	3.6e-09	507	779
STKc_MST1_2	cd06612	6.1e-07	507	771
STKc_MEKK3	cd06651	1.3e-06	507	773
STKc_MEKK2	cd06652	0.00043	507	781
STKc_MEKK3_like_1	cd06653	2.7e-06	507	780
PTKc_Tie1	cd05089	2.9e-40	508	805
STKc_PDK1	cd05581	2.4e-07	508	779
PKc_MAPKK	cd06605	1.2e-05	508	781
STKc_MST3_like	cd06609	4.4e-08	508	791
PKc_MKK3_6	cd06617	9.1e-05	508	796
PKc_MAPKK_Pek1_like	cd06621	1.6e-05	508	787
PKc_MAPKK_plant_like	cd06623	3.4e-10	508	782
PKc_MAPKK_PBS2_like	cd06622	3.4e-05	508	815
STKc_Nek6_Nek7	cd08224	3.9e-05	508	782
STKc_Nek6	cd08228	5.2e-05	508	782
STKc_Nek7	cd08229	9.1e-07	508	782
SPS1	COG0515	4.9e-15	508	862
PTKc_RET	cd05045	3.9e-48	509	781
PKc_STE	cd05122	2.6e-11	509	770
STKc_Yank1	cd05578	0.00024	509	780
STKc_GRK4_like	cd05605	0.00056	509	820
STKc_MAPKKK	cd06606	7.9e-16	509	780
STKc_Cdc7_like	cd06627	2.2e-11	509	775
STKc_CCRK	cd07832	4.1e-05	509	793
STKc_CDK7	cd07841	1.4e-05	509	792
STKc_Pho85	cd07836	0.00017	509	812
STKc_Nek	cd08215	1.3e-10	509	779
STKc_Nek3	cd08219	1.7e-09	509	779
STKc_Nek8	cd08220	0.00037	509	779
STKc_Nek9	cd08221	6.5e-07	509	779
STKc_Nek11	cd08222	1.7e-06	509	780
STKc_Nek4	cd08223	3.3e-06	509	780
STKc_Nek5	cd08225	2.2e-06	509	779
STKc_Nek1	cd08218	9.3e-05	509	779
STKc_Nek10	cd08528	0.00041	509	779
STKc_CNK2-like	cd08530	3.3e-06	509	779
STKc_FA2-like	cd08529	2.7e-05	509	777
PTKc_Axl_like	cd05035	8.6e-68	510	781
PTKc_Tyro3	cd05074	1.1e-64	510	781
PTKc_Axl	cd05075	6.7e-59	510	781
PTKc_Tyk2_rpt2	cd05080	3.8e-15	510	782
PTKc_Jak2_Jak3_rpt2	cd05081	3.6e-21	510	781
STKc_PKN	cd05589	7.6e-05	510	837
STKc_MAPKKK_Byr2_lik	cd06628	9.6e-09	510	779
STKc_CMGC	cd05118	7.4e-06	511	780
PTKc_Srm_Brk	cd05148	3e-52	511	780
STKc_YSK4	cd06631	3.3e-09	511	779
STKc_NAK1_like	cd06917	1.1e-09	511	791
STKc_CDK_like	cd07829	4e-07	511	775
STKc_MAK_like	cd07830	8.1e-05	511	779
STKc_OSR1_SPAK	cd06610	1.9e-09	512	779
STKc_MEKK4	cd06626	3.6e-07	512	771
STKc_MOK	cd07831	3.8e-05	512	780
STKc_CDK9_like	cd07840	5.7e-06	512	812
STKc_Nek2	cd08217	1.2e-09	512	779
STKc_RSK_N	cd05582	0.00072	513	843
PTKc	cd00192	9.9e-120	514	778
PTK_Jak_rpt1	cd05037	5e-13	514	778
PTKc_Ack_like	cd05040	7.2e-43	514	779
PTKc_Fes_like	cd05041	1.8e-71	514	779
PTKc_Aatyk	cd05042	6.2e-22	514	779
PTKc_c-ros	cd05044	1e-114	514	779
PTKc_Tie	cd05047	4.3e-45	514	782
PTKc_Met_Ron	cd05058	1.5e-65	514	783
PTKc_Syk_like	cd05060	5.2e-54	514	782
PTK_Tyk2_rpt1	cd05076	1.7e-06	514	778
PTK_Jak1_rpt1	cd05077	5.6e-08	514	778
PTK_Jak2_Jak3_rpt1	cd05078	5.8e-11	514	778
PTKc_Fes	cd05084	1.5e-71	514	779
PTKc_Fer	cd05085	1.7e-67	514	779
PTKc_Aatyk2	cd05086	1.2e-20	514	779
PTKc_Aatyk1_Aatyk3	cd05087	1.2e-38	514	779
PTKc_Syk	cd05116	8.7e-42	514	782
STKc_MEKK1	cd06630	2.7e-05	514	776
STKc_MEKK1_plant	cd06632	4.6e-08	514	775
PTKc_Zap-70	cd05115	8.4e-42	515	782
PKc	cd00180	3.8e-52	516	777
STKc_AGC	cd05123	2.4e-06	516	772
STKc_cGK_PKG	cd05572	4.7e-05	516	781
STKc_MAST_like	cd05579	0.00017	516	775
STKc_MAPKKK_Bck1_lik	cd06629	1.7e-08	517	780
Pkinase	pfam00069	2.3e-21	510	777
Pkinase_Tyr	pfam07714	2.1e-135	510	777
TyrKc	smart00219	1.8e-125	510	777
STYKc	smart00221	3e-44	510	840
S_TKc	smart00220	3.1e-27	520	780

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs2305030	Polymorphism	p.ARG42GLN	N/A
Swiss-Prot	VAR_046109	Polymorphism	p.ARG673GLN	N/A
Swiss-Prot	VAR_046108	Polymorphism	p.ARG569SER	N/A
dbSNP	rs35932273	Polymorphism	p.ASP535ASN	N/A
Swiss-Prot	VAR_046106	Polymorphism	p.CYS384ARG	N/A
Swiss-Prot	VAR_065465	Polymorphism	p.GLU763LYS	N/A
dbSNP	rs55739813	Polymorphism	p.PRO227LEU	N/A
Swiss-Prot	VAR_046110	Polymorphism	p.PRO745SER	N/A
Swiss-Prot	VAR_046111	Polymorphism	p.PRO838SER	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258