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Results for the Protein: P51178
206729887

PLCD1_HUMAN RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; AltName: Full=Phosphoinositide phospholipase C-delta-1; AltName: Full=Phospholipase C-III; Short=PLC-III; AltName: Full=Phospholipase C-delta-1; Short=PLC-delta-1

Known Diseases associated with this Protein:
  NAIL DISORDER, NON-SYNDROMIC CONGENITAL, 3 (NDNC3)
  NAIL DISORDER, NONSYNDROMIC CONGENITAL, 3
5
2
3
2
2
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

PH_PLC_ELMO1 - cd01248
PH - pfam00169
PH - smart00233
PH-like - cd00900
PH - cd00821
EFh - smart00054
EFh - cd00051
efhand_like - pfam09279
PI-PLCc_gamma2 - cd08628
PI-PLCc_beta3 - cd08625
PI-PLCc_beta4 - cd08626
PI-PLCc_delta1 - cd08629
PI-PLCc_beta2 - cd08624
PI-PLCc_eta2 - cd08633
PI-PLCc_eta1 - cd08632
PI-PLCc_delta4 - cd08631
PI-PLCc_delta3 - cd08630
PI-PLCc - cd00137
PI-PLCc_beta - cd08591
PI-PLCc_eukaryota - cd08558
PI-PLCc_gamma - cd08592
PI-PLCc_beta1 - cd08623
PI-PLCc_delta - cd08593
PI-PLCc_eta - cd08594
PI-PLCc_plant - cd08599
PI-PLCc_zeta - cd08595
PI-PLC1c_yeast - cd08598
PI-PLCc_PRIP_metazoa - cd08597
PI-PLCc_epsilon - cd08596
PLCXc - smart00148
PI-PLC-X - pfam00388
PI-PLCc_GDPD_SF - cd08555
PI-PLC-Y - pfam00387
PLCYc - smart00149
C2B_Munc13-like - cd04009
C2_PLC_like - cd00275
C2B_Synaptotagmin - cd00276
C2 - smart00239
C2 - cd00030
C2_KIAA0528-like - cd08688
C2 - pfam00168


Swiss-Prot Protein: P51178
Identical to: NP_006216
   Default View:


























Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
PH_PLC_ELMO1cd012482.3e-4417128
PHcd008219.9e-0724128
PH-likecd009000.0003624128
EFhcd000510.00021144206
PI-PLCccd001372.1e-173295596
PI-PLCc_eukaryotacd085586.1e-172295596
PI-PLCc_gammacd085921.6e-09295756
PI-PLCc_deltacd085937.1e-231295596
PI-PLCc_betacd085912.9e-83295596
PI-PLCc_etacd085941.2e-67295596
PI-PLCc_zetacd085951.1e-134295596
PI-PLCc_epsiloncd085961.8e-33295596
PI-PLCc_PRIP_metazoacd085973.5e-138295596
PI-PLC1c_yeastcd085989.1e-106295596
PI-PLCc_plantcd085991.9e-56295596
PI-PLCc_beta1cd086236.4e-60295596
PI-PLCc_beta2cd086241.5e-69295596
PI-PLCc_beta3cd086254.1e-62295596
PI-PLCc_beta4cd086264e-65295596
PI-PLCc_gamma2cd086282e-08295755
PI-PLCc_delta3cd086308.2e-161295596
PI-PLCc_delta4cd086315.3e-148295596
PI-PLCc_eta1cd086322.7e-59295596
PI-PLCc_eta2cd086332.9e-46295596
PI-PLCc_delta1cd086293.7e-221295596
PI-PLCc_GDPD_SFcd085553.8e-88308579
C2B_Munc13-likecd040093.3e-05611750
C2_PLC_likecd002751e-61628755
C2B_Synaptotagmincd002761.8e-05629748
C2cd000302.4e-17631752
C2_KIAA0528-likecd086880.00022631742
PHpfam001694.2e-0921130
PI-PLC-Xpfam003883.8e-95298441
PI-PLC-Ypfam003872.3e-73491609
C2pfam001681.2e-24631720
PHsmart002332.5e-1022130
EFhsmart000540.00073144172
efhand_likepfam092791.4e-30213295
PLCXcsmart001481.6e-87296430
PLCYcsmart001495.9e-71493608
C2smart002394.1e-29630735

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs933135 Polymorphismp.ARG257HISN/A
dbSNPrs61755441 Polymorphismp.ASP231ASNN/A
Swiss-ProtVAR_066400Diseasep.ILE574THRNail disorder, non-syndromic congenital, 3 (NDNC3)
Swiss-ProtVAR_066399Diseasep.THR209ARGNail disorder, non-syndromic congenital, 3 (NDNC3)
OMIM602142.0003 Diseasep.ALA553THRNAIL DISORDER, NONSYNDROMIC CONGENITAL, 3
OMIM602142.0001 Diseasep.ARG416TERNAIL DISORDER, NONSYNDROMIC CONGENITAL, 3
OMIM602142.0004 Diseasep.CYS188ARGNAIL DISORDER, NONSYNDROMIC CONGENITAL, 3



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