Results for the protein: P23458

Results for the Protein: P23458

215274013

3716

JAK1

NCBI, UniProt

JAK1_HUMAN RecName: Full=Tyrosine-protein kinase JAK1; AltName: Full=Janus kinase 1; Short=JAK-1

			0 1 0 0 1

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Swiss-Prot Protein: P23458

Identical to: NP_002218

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_Abl	cd05052	1.2e-12	577	849
PTKc_FAK	cd05056	5.5e-18	577	853
PTKc_Lck_Blk	cd05067	1.7e-06	577	845
PTKc_Frk_like	cd05068	9.3e-18	577	848
PTKc_Yes	cd05069	2.3e-08	577	848
PTKc_Fyn_Yrk	cd05070	2.2e-07	577	845
PTKc_Src	cd05071	1.8e-07	577	847
PTKc_Lyn	cd05072	4.4e-08	577	848
PTKc_Hck	cd05073	4.7e-09	577	845
PTKc_Csk	cd05082	1e-08	577	848
PTKc_TrkA	cd05092	1.6e-08	577	851
PTKc_TrkB	cd05093	2.1e-08	577	857
PTKc_EphR_A2	cd05063	9.4e-08	577	849
PTKc_DDR_like	cd05097	4e-07	577	847
PTKc_Jak1_rpt2	cd05079	2.3e-05	578	849
PTKc_Itk	cd05112	3.9e-10	578	846
PTKc_Btk_Bmx	cd05113	1.3e-09	578	846
PTKc_Tec_Rlk	cd05114	2.2e-12	578	846
PTKc_EphR_A10	cd05064	2.3e-08	579	849
PTKc_EphR_B	cd05065	1.3e-08	579	849
PTKc_EphR_A	cd05066	1.8e-07	579	849
PKc_MKK3_6	cd06617	7.1e-07	581	864
SPS1	COG0515	3.6e-15	581	1024
PTKc_Tyro3	cd05074	1e-06	583	849
PTKc_Chk	cd05083	1.2e-09	583	848
PTKc	cd00192	8.6e-36	587	846
PTK_Jak_rpt1	cd05037	3.8e-152	587	846
PTKc_Met_Ron	cd05058	3.9e-07	587	851
PTK_Tyk2_rpt1	cd05076	5.9e-138	587	846
PTK_Jak1_rpt1	cd05077	1e-217	587	846
PTK_Jak2_Jak3_rpt1	cd05078	2.2e-125	587	846
PTKc_Fes	cd05084	9.4e-14	587	847
PTKc_Fer	cd05085	8.9e-13	587	847
STKc_PKB	cd05571	0.00019	587	910
PKc	cd00180	8.4e-29	589	845
PTKc_Zap-70	cd05115	6.3e-12	595	850
PTKc_Syk	cd05116	1.3e-08	595	850
PTKc_PDGFR_alpha	cd05105	3.1e-11	749	1154
PTKc_PDGFR_beta	cd05107	5.9e-08	755	1154
PTKc_VEGFR	cd05054	1.4e-09	758	1154
PTKc_CSF-1R	cd05106	3.4e-10	835	1154
STKc_myosinIIIB	cd06639	6.5e-05	845	1154
STKc_myosinIIIA	cd06638	0.00024	848	1151
STKc_PAK	cd06614	1.8e-12	849	1153
PTKc_Kit	cd05104	1.5e-11	850	1153
STKc_TAO	cd06607	0.00018	852	1154
STKc_PAK3	cd06656	0.00088	852	1154
PKc_MKK7	cd06618	3.6e-05	854	1148
STKc_PAK_I	cd06647	0.00053	854	1154
PTKc_PDGFR	cd05055	3e-15	855	1153
STKc_PAK6	cd06659	9.2e-06	855	1151
PTKc_FGFR1	cd05098	1.1e-33	856	1154
STKc_PAK4	cd06657	0.00094	856	1152
STKc_PAK5	cd06658	0.00033	856	1132
STKc_TAO1	cd06635	0.00091	857	1154
STKc_PAK_II	cd06648	2e-06	858	1146
STKc_STK10_LOK	cd06644	1.5e-06	859	1153
PTKc_FGFR2	cd05101	5.6e-32	860	1154
STKc_MAP4K4_6	cd06636	0.00043	860	1133
PTKc_EGFR_like	cd05057	1.9e-48	862	1154
STKc_TAO2	cd06634	7e-05	862	1144
STKc_p38	cd07851	7.4e-05	862	1136
PTKc_FGFR	cd05053	4.5e-34	863	1154
PTKc_FGFR4	cd05099	5.4e-36	863	1154
PTKc_FGFR3	cd05100	8.3e-19	863	1154
STKc_CDK10	cd07845	4.6e-09	863	1121
PTKc_EphR_A2	cd05063	5.8e-38	864	1153
STKc_MAP4K5	cd06646	2.1e-05	864	1125
STKc_TNIK	cd06637	2.7e-05	864	1133
STKc_CDK9	cd07865	1.7e-07	864	1150
STKc_SLK_like	cd06611	7.1e-09	865	1148
STKc_Sty1_Hog1	cd07856	1.8e-05	865	1149
STKc_BUR1	cd07866	2.1e-08	865	1142
STKc_ASK	cd06624	1.7e-09	866	1153
STKc_MST4	cd06640	3.2e-08	866	1153
STKc_MST3	cd06641	2.2e-07	866	1153
STKc_STK25-YSK1	cd06642	7.9e-09	866	1153
STKc_MEKK2	cd06652	1.5e-09	867	1134
PTKc_ALK_LTK	cd05036	1.8e-28	868	1151
PTKc_DDR	cd05051	3.1e-21	868	1147
PTKc_FAK	cd05056	1.4e-55	868	1154
PTKc_Tie2	cd05088	5.1e-20	868	1154
PKc_MAPKK_plant_like	cd06623	1.4e-12	868	1151
STKc_ERK1_2_like	cd07849	5.1e-06	868	1154
STKc_MAPK4_6	cd07854	4.2e-05	868	1150
STKc_TEY_MAPK_plant	cd07858	0.00014	868	1154
PTKc_Ror	cd05048	2.3e-34	869	1152
PTKc_Trk	cd05049	1e-40	869	1151
PTKc_Musk	cd05050	2.3e-40	869	1151
PTKc_Abl	cd05052	1.3e-50	869	1153
PTK_CCK4	cd05046	6.4e-32	869	1151
PTKc_InsR	cd05061	2.1e-19	869	1154
PTKc_IGF-1R	cd05062	1.8e-27	869	1151
PTKc_EphR_A10	cd05064	9.5e-32	869	1153
PTKc_Lck_Blk	cd05067	2.4e-47	869	1149
PTKc_Frk_like	cd05068	2.2e-65	869	1152
PTKc_Yes	cd05069	6.1e-32	869	1149
PTKc_Fyn_Yrk	cd05070	5.2e-33	869	1152
PTKc_Src	cd05071	3.1e-33	869	1154
PTKc_Lyn	cd05072	7.9e-42	869	1149
PTKc_Hck	cd05073	1.8e-42	869	1149
PTKc_Csk	cd05082	3.8e-42	869	1152
PTKc_Ror1	cd05090	2.1e-29	869	1152
PTKc_Ror2	cd05091	3.5e-21	869	1152
PTKc_TrkA	cd05092	3.6e-42	869	1151
PTKc_TrkB	cd05093	1.1e-35	869	1154
PTKc_TrkC	cd05094	1.5e-26	869	1154
PTKc_DDR2	cd05095	7.2e-32	869	1151
PTKc_DDR_like	cd05097	9.5e-34	869	1151
PTKc_DDR1	cd05096	6e-26	869	1151
PTKc_VEGFR3	cd05102	8.5e-12	869	1154
PTKc_VEGFR2	cd05103	7.9e-14	869	1154
STKc_Yank1	cd05578	1.1e-06	869	1128
STKc_SLK	cd06643	1.2e-06	869	1151
STKc_MAP4K3	cd06645	4.2e-05	869	1149
STKc_PCTAIRE_like	cd07844	1e-07	869	1151
STKc_ERK5	cd07855	0.00042	869	1154
STKc_PFTAIRE2	cd07870	0.00012	869	1150
STKc_PCTAIRE2	cd07872	1.4e-05	869	1154
STKc_PCTAIRE1	cd07873	1.1e-05	869	1154
PTKc_InsR_like	cd05032	1.1e-38	870	1151
PTKc_Src_like	cd05034	3.9e-48	870	1152
PTKc_Jak_rpt2	cd05038	3.7e-212	870	1153
PTKc_Tec_like	cd05059	4.3e-24	870	1150
PTKc_EphR	cd05033	7.9e-37	870	1153
PTKc_EphR_B	cd05065	1.3e-34	870	1153
PTKc_EphR_A	cd05066	6.3e-41	870	1153
PTKc_Tyk2_rpt2	cd05080	5.2e-162	870	1154
PTKc_Jak2_Jak3_rpt2	cd05081	4e-152	870	1153
PTKc_Chk	cd05083	3e-43	870	1152
PTKc_Jak1_rpt2	cd05079	2.1e-237	870	1153
PTKc_EGFR	cd05108	2e-26	870	1154
PTKc_HER4	cd05110	6.3e-29	870	1150
PTK_HER3	cd05111	2e-38	870	1154
PTKc_Itk	cd05112	3.7e-39	870	1150
PTKc_HER2	cd05109	2.3e-37	870	1154
PTKc_Btk_Bmx	cd05113	4.2e-46	870	1150
PTKc_Tec_Rlk	cd05114	4.7e-40	870	1150
STKc_MAP4K3_like	cd06613	2.6e-10	870	1122
STKc_MST1_2	cd06612	1.1e-11	870	1146
PKc_MKK4	cd06616	3.5e-05	870	1153
STKc_MAPK15	cd07852	4.7e-08	870	1153
STKc_CDK12	cd07864	1.1e-10	870	1150
STKc_PCTAIRE3	cd07871	8.7e-07	870	1151
STKc_CDKL5	cd07848	0.00026	871	1151
PTKc_RET	cd05045	1e-32	872	1154
STKc_ROCK_NDR_like	cd05573	0.00083	872	1150
PKc_MAPKK_Pek1_like	cd06621	6.8e-10	872	1132
STKc_MEKK3_like_1	cd06653	7.9e-11	872	1151
STKc_CDC2L1	cd07843	3.5e-07	872	1142
STKc_CDKL1_4	cd07847	2e-09	872	1151
STKc_Nek6_Nek7	cd08224	9.7e-08	872	1154
STKc_phototropin_lik	cd05574	0.00029	873	1128
STKc_PKA	cd05580	1.6e-09	873	1125
STKc_PRKX_like	cd05612	1.5e-06	873	1153
PKc_MEK	cd06615	4.3e-07	873	1153
STKc_Cdc7_like	cd06627	1.5e-16	873	1146
STKc_MST3_like	cd06609	1.1e-11	873	1115
STKc_NAK1_like	cd06917	2e-08	873	1150
STKc_CDK7	cd07841	1.6e-13	873	1146
STKc_MPK1	cd07857	7.6e-06	873	1152
STKc_CDK1_euk	cd07861	3.5e-12	873	1151
STKc_CDK6	cd07862	5.1e-06	873	1151
STKc_Nek11	cd08222	1.6e-06	873	1151
STKc_CNK2-like	cd08530	1.2e-08	873	1152
PKc_STE	cd05122	2.2e-14	874	1149
STKc_GRK4_like	cd05605	0.00042	874	1153
STKc_MAPKKK	cd06606	5.8e-26	874	1151
STKc_YSK4	cd06631	4.1e-10	874	1143
STKc_MAPK	cd07834	2.9e-07	874	1152
STKc_CDK8_like	cd07842	7.2e-08	874	1150
STKc_CDK2_3	cd07860	1.3e-10	874	1149
STKc_CDC2L6	cd07867	0.00033	874	1150
STKc_Nek	cd08215	1.5e-14	874	1152
PTKc_Axl_like	cd05035	1.6e-36	875	1153
PTKc_Tyro3	cd05074	1.5e-37	875	1153
PTKc_Axl	cd05075	2.9e-21	875	1153
STKc_CMGC	cd05118	2.3e-14	875	1142
STKc_MSK_N	cd05583	7e-05	875	1148
STKc_PKN	cd05589	0.0003	875	1152
STKc_MSK1_N	cd05613	0.00094	875	1136
PKc_MAPKK	cd06605	4e-10	875	1151
PKc_MAPKK_Byr1_like	cd06620	1.2e-06	875	1154
STKc_MEKK3	cd06651	8.3e-14	875	1128
PKc_MAPKK_PBS2_like	cd06622	0.0008	875	1154
STKc_CDK_like	cd07829	4.3e-16	875	1149
STKc_MAK_like	cd07830	5e-11	875	1142
STKc_CDK1_like	cd07835	3.9e-12	875	1151
STKc_Pho85	cd07836	3e-11	875	1149
STKc_CDK4_6_like	cd07838	1.5e-08	875	1142
STKc_MOK	cd07831	2.4e-09	875	1149
STKc_CDK9_like	cd07840	3.4e-11	875	1142
STKc_CDK4	cd07863	2e-07	875	1150
STKc_Nek3	cd08219	3.4e-09	875	1132
STKc_Nek5	cd08225	2.4e-05	875	1153
STKc_Nek6	cd08228	7.4e-06	875	1152
STKc_Nek7	cd08229	5.6e-08	875	1151
STKc_Nek1	cd08218	2.2e-07	875	1153
PTK_Ryk	cd05043	9.9e-21	876	1152
STKc_PDK1	cd05581	1e-08	876	1154
STKc_OSR1_SPAK	cd06610	2.9e-10	876	1149
STKc_MEKK3_like	cd06625	6.3e-21	876	1151
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-19	876	1153
STKc_CCRK	cd07832	1.4e-10	876	1143
STKc_CDKL	cd07833	1.1e-09	876	1149
STKc_CdkB_plant	cd07837	1.1e-11	876	1150
STKc_CDK5	cd07839	1.4e-07	876	1149
STKc_CDKL2_3	cd07846	1.5e-08	876	1149
PK_STRAD	cd08216	0.00041	876	1154
STKc_Nek2	cd08217	1.3e-07	876	1151
STKc_Nek8	cd08220	1.2e-07	876	1133
STKc_Nek9	cd08221	2.5e-07	876	1151
PTKc_Tie1	cd05089	1.9e-18	877	1154
STKc_MEKK4	cd06626	3.3e-08	877	1151
PTKc_Csk_like	cd05039	1.8e-23	878	1152
PTKc_Srm_Brk	cd05148	1.7e-37	878	1152
STKc_RSK_N	cd05582	0.00029	878	1152
STKc_myosinIII_like	cd06608	5.5e-08	878	1105
STKc_Nek4	cd08223	1.2e-06	878	1151
STKc_Nek10	cd08528	4.5e-06	878	1148
STKc_FA2-like	cd08529	2.5e-07	878	1152
PTKc	cd00192	9.8e-100	879	1150
PTKc_Ack_like	cd05040	2.1e-54	879	1151
PTKc_Fes_like	cd05041	4.6e-38	879	1151
PTKc_Aatyk	cd05042	6.8e-12	879	1142
PTKc_c-ros	cd05044	4.7e-40	879	1151
PTKc_Met_Ron	cd05058	1.6e-51	879	1154
PTKc_Syk_like	cd05060	1.2e-56	879	1154
PTKc_Fes	cd05084	2e-42	879	1151
PTKc_Aatyk2	cd05086	1.2e-08	879	1151
PTKc_Aatyk1_Aatyk3	cd05087	2.1e-15	879	1151
PTKc_Syk	cd05116	6.6e-54	879	1154
STKc_PKC	cd05570	6.7e-07	879	1152
STKc_PKB_alpha	cd05594	0.00092	879	1151
STKc_nPKC_theta	cd05619	6.6e-05	879	1154
PTKc_Tie	cd05047	5.1e-34	880	1154
PTKc_Zap-70	cd05115	2.6e-54	880	1154
PKc	cd00180	1.1e-59	881	1149
PTKc_Fer	cd05085	2.7e-41	881	1151
STKc_AGC	cd05123	2.8e-09	881	1152
STKc_cGK_PKG	cd05572	1.1e-06	881	1148
STKc_GRK	cd05577	0.00074	881	1122
STKc_MAST_like	cd05579	9e-08	881	1116
STKc_GRK1	cd05608	4.1e-05	881	1122
STKc_MEKK1_plant	cd06632	3.1e-13	881	1147
STKc_MAPKKK_Bck1_lik	cd06629	3.1e-09	882	1150
STKc_MEKK1	cd06630	9.1e-08	885	1150
Pkinase	pfam00069	7.9e-12	583	845
Pkinase	pfam00069	6e-35	875	1149
B41	smart00295	1.6e-81	33	286
SH2	smart00252	2.3e-14	437	532
Pkinase_Tyr	pfam07714	5.1e-82	583	845
TyrKc	smart00219	5e-15	583	845
STYKc	smart00221	2.9e-15	583	847
S_TKc	smart00220	2.8e-10	609	847
Pkinase_Tyr	pfam07714	6.5e-142	875	1149
TyrKc	smart00219	3.9e-141	875	1149
STYKc	smart00221	1.1e-54	875	1122
S_TKc	smart00220	4.7e-52	885	1153

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041715	Polymorphism	p.ASN973LYS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258