Home News About DMDM Database Statistics Research Publications Contact  

Results for the Protein: P16885
215274231

PLCG2_HUMAN RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; AltName: Full=Phosphoinositide phospholipase C-gamma-2; AltName: Full=Phospholipase C-IV; Short=PLC-IV; AltName: Full=Phospholipase C-gamma-2; Short=PLC-gamma-2

Known Diseases associated with this Protein:
  AUTOINFLAMMATION, ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION PLCG2-ASSOCIATED (APLAID)
  AUTOINFLAMMATION, ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED
2
8
1
4
5
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

PH_PLC_ELMO1 - cd01248
PH - smart00233
PH - pfam00169
PI-PLCc_delta1 - cd08629
PI-PLCc_beta3 - cd08625
PI-PLCc_gamma2 - cd08628
PI-PLCc_beta4 - cd08626
PI-PLCc_eta2 - cd08633
PI-PLCc_delta - cd08593
PI-PLCc_eta1 - cd08632
PI-PLCc_delta4 - cd08631
PI-PLCc_delta3 - cd08630
PI-PLCc_beta2 - cd08624
PI-PLCc_gamma - cd08592
PI-PLCc_beta - cd08591
PI-PLCc_eukaryota - cd08558
PI-PLCc - cd00137
PI-PLCc_eta - cd08594
PI-PLCc_PRIP_metazoa - cd08597
PI-PLCc_zeta - cd08595
PI-PLCc_plant - cd08599
PI-PLC1c_yeast - cd08598
PI-PLCc_beta1 - cd08623
PI-PLCc_epsilon - cd08596
PLCXc - smart00148
PI-PLCc_gamma1 - cd08627
PI-PLC-X - pfam00388
PI-PLCc_GDPD_SF - cd08555
SH2 - smart00252
SH2 - cd00173
SH2 - pfam00017
SH3 - smart00326
SH3 - cd00174
SH3_1 - pfam00018
PI-PLC-Y - pfam00387
PLCYc - smart00149
C2_PLC_like - cd00275
C2 - smart00239
C2 - cd00030
C2 - pfam00168


Swiss-Prot Protein: P16885
Identical to: NP_002652
   Default View:




























Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
PH_PLC_ELMO1cd012482.5e-4417129
PI-PLCccd001376.5e-30311541
PI-PLCc_eukaryotacd085581.6e-2793111031
PI-PLCc_betacd085911.1e-293111031
PI-PLCc_gammacd085923111031
PI-PLCc_etacd085941.8e-32311691
PI-PLCc_PRIP_metazoacd085971.2e-46311536
PI-PLCc_epsiloncd085962.2e-18311644
PI-PLC1c_yeastcd085981.5e-45311584
PI-PLCc_plantcd085992.8e-21311604
PI-PLCc_zetacd085959.8e-43311604
PI-PLCc_beta1cd086233.8e-18311672
PI-PLCc_beta2cd086241.3e-32311630
PI-PLCc_beta3cd086255.7e-24311693
PI-PLCc_beta4cd086262.8e-193111031
PI-PLCc_delta1cd086291e-60311604
PI-PLCc_gamma2cd086283111031
PI-PLCc_delta3cd086301.7e-45311564
PI-PLCc_delta4cd086312.4e-53311609
PI-PLCc_eta2cd086331e-20311709
PI-PLCc_eta1cd086322.3e-33311736
PI-PLCc_deltacd085937.7e-50311630
PI-PLCc_gamma1cd086272.8e-2853121031
PI-PLCc_GDPD_SFcd085551.6e-18324564
SH2cd001733.5e-33531635
SH2cd001733.5e-32645735
PI-PLCc_delta4cd086311.5e-067101031
PI-PLCc_delta1cd086293.7e-077431031
SH3cd001744.5e-18773826
C2_PLC_likecd002751e-5510601187
C2cd000304e-1310631177
PHpfam001690.00122131
PI-PLC-Xpfam003881.5e-95314457
SH2pfam000175.4e-43532617
SH2pfam000175e-30646720
SH3_1pfam000186.1e-17775821
PI-PLC-Ypfam003872.8e-669291044
C2pfam001685e-2110631152
PHsmart002335.7e-0622131
PLCXcsmart001484.8e-91312446
SH2smart002522.2e-36530623
SH2smart002529.6e-28644726
SH3smart003261.9e-19770827
PLCYcsmart001496.7e-659311043
C2smart002394.4e-2610621167

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs1071644 Polymorphismp.ARG1031SERN/A
Swiss-ProtVAR_031561Polymorphismp.ARG268TRPN/A
Swiss-ProtVAR_047428Polymorphismp.ASP883TYRN/A
Swiss-ProtVAR_031560Polymorphismp.HIS244ARGN/A
dbSNPrs115583707 Polymorphismp.PHE838LEUN/A
Swiss-ProtVAR_069211Diseasep.SER707TYRAutoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID)
Swiss-ProtVAR_047427Polymorphismp.THR541ALAN/A
dbSNPrs4586425 rs1143685 Polymorphismp.TRP58CYSN/A
dbSNPrs17537869 rs1143687 Polymorphismp.VAL268LEUN/A
OMIM600220.0004 Diseasep.SER707TYRAUTOINFLAMMATION, ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED



   |   1000 Hilltop Circle, Baltimore, MD 21250   |   Department of Biological Sciences   |   Phone: 410-455-2258