Results for the protein: Q16620

Results for the Protein: Q16620

2497560

4915

NTRK2

NCBI, UniProt

NTRK2_HUMAN RecName: Full=BDNF/NT-3 growth factors receptor; AltName: Full=GP145-TrkB; Short=Trk-B; AltName: Full=Neurotrophic tyrosine kinase receptor type 2; AltName: Full=TrkB tyrosine kinase; AltName: Full=Tropomyosin-related kinase B; Flags: Precursor

Known Diseases associated with this Protein:
OBESITY HYPERPHAGIA AND DEVELOPMENTAL DELAY (OHPDD)
OBESITY, HYPERPHAGIA, AND DEVELOPMENTAL DELAY

2

7

1

0

8

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Swiss-Prot Protein: Q16620

Identical to: NP_001018074

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Ig3_Contactin-1	cd05851	0.0007	196	284
Ig3_Contactin_like	cd04968	5.7e-05	197	284
Ig_TrkABC_d4	cd04972	1.9e-10	198	283
Ig5_NCAM-1_like	cd05732	0.00058	202	283
Ig2_FGFR_like	cd05729	0.00067	203	283
Ig3_Peroxidasin	cd05745	0.00011	210	283
Ig_2	cd05764	3.1e-05	211	283
Ig	cd00096	3.1e-08	214	280
Ig3_Robo	cd05725	1.7e-05	214	283
Ig_TrKABC_d5	cd04971	8.3e-57	301	379
Ig_TrkB_d5	cd05855	1.1e-57	301	379
PTKc_CSF-1R	cd05106	3e-37	500	812
PTKc_Kit	cd05104	1.9e-25	503	811
PTKc_PDGFR_alpha	cd05105	3.9e-17	506	813
PTKc_PDGFR_beta	cd05107	3e-19	506	812
PTKc_PDGFR	cd05055	6.3e-24	507	811
STKc_myosinIIIB	cd06639	4.2e-05	516	812
STKc_myosinIIIA	cd06638	5.6e-06	517	807
STKc_ERK5	cd07855	0.00074	517	818
PTKc_FGFR1	cd05098	4.8e-57	518	817
STKc_PAK6	cd06659	1.5e-05	519	816
PTKc_FGFR2	cd05101	1.5e-53	521	811
PTKc_EGFR_like	cd05057	9.8e-57	522	821
STKc_PAK4	cd06657	0.00091	522	802
STKc_PAK_I	cd06647	0.00092	522	822
PKc_MKK7	cd06618	1.2e-05	523	819
STKc_CDK9	cd07865	1.3e-05	523	821
PTKc_FGFR	cd05053	5.8e-64	524	811
STKc_SLK	cd06643	9.7e-08	524	813
STKc_TAO2	cd06634	0.00021	525	820
PTKc_FGFR4	cd05099	6.8e-60	526	820
PTKc_FGFR3	cd05100	1.8e-41	526	820
STKc_PAK_II	cd06648	1.7e-07	526	821
PTK_Tyk2_rpt1	cd05076	1.1e-06	528	811
STKc_PAK	cd06614	1.1e-12	528	821
STKc_CDK10	cd07845	5.7e-07	528	819
STKc_Sty1_Hog1	cd07856	0.00022	528	819
STKc_ASK	cd06624	3.4e-07	529	812
STKc_p38	cd07851	6.5e-05	529	812
STKc_CDK12	cd07864	2.7e-08	529	821
STKc_BUR1	cd07866	4.3e-10	529	799
PTKc_Tie2	cd05088	1.9e-44	530	820
PTKc_EGFR	cd05108	5.5e-22	530	822
PTKc_HER2	cd05109	3.3e-39	530	821
PTK_HER3	cd05111	7.3e-38	530	821
PTKc_HER4	cd05110	9.2e-24	530	822
STKc_SLK_like	cd06611	1.8e-09	530	809
STKc_STK10_LOK	cd06644	8.7e-07	530	817
PTKc_ALK_LTK	cd05036	9.5e-87	531	809
PTKc_FAK	cd05056	2.2e-78	531	815
STKc_MAPK15	cd07852	5.5e-06	531	820
PTK_CCK4	cd05046	1.7e-75	532	809
PTKc_Ror	cd05048	4.6e-120	532	810
PTKc_Trk	cd05049	4.1e-238	532	809
PTKc_Musk	cd05050	3.4e-135	532	809
PTKc_DDR	cd05051	1.1e-106	532	809
PTKc_Abl	cd05052	9.5e-72	532	811
PTKc_VEGFR	cd05054	2.8e-31	532	814
PTKc_InsR	cd05061	2.4e-83	532	820
PTKc_EphR_A2	cd05063	6.2e-66	532	811
PTKc_EphR_A10	cd05064	2.3e-59	532	811
PTKc_Lck_Blk	cd05067	2.1e-52	532	810
PTKc_Frk_like	cd05068	1.8e-76	532	810
PTKc_Yes	cd05069	8.4e-45	532	810
PTKc_Fyn_Yrk	cd05070	6.9e-50	532	810
PTKc_Src	cd05071	1.2e-46	532	812
PTKc_Lyn	cd05072	2.3e-55	532	810
PTKc_Hck	cd05073	1.8e-54	532	810
PTKc_IGF-1R	cd05062	1.5e-80	532	809
PTKc_Tyk2_rpt2	cd05080	3.8e-45	532	812
PTKc_Jak2_Jak3_rpt2	cd05081	1.9e-48	532	811
PTKc_Csk	cd05082	4.1e-49	532	810
PTKc_Ror1	cd05090	1e-92	532	810
PTKc_Ror2	cd05091	9.6e-86	532	810
PTKc_TrkA	cd05092	5.4e-205	532	809
PTKc_TrkB	cd05093	2.3e-279	532	819
PTKc_TrkC	cd05094	1.4e-209	532	819
PTKc_DDR2	cd05095	9.9e-92	532	809
PTKc_DDR_like	cd05097	5.1e-92	532	809
PTKc_VEGFR3	cd05102	3.5e-36	532	814
PTKc_VEGFR2	cd05103	4.4e-29	532	814
PTKc_DDR1	cd05096	4e-85	532	809
PKc_MAPKK_Byr1_like	cd06620	4.7e-09	532	822
STKc_MAP4K3	cd06645	5.5e-05	532	811
STKc_MAP4K5	cd06646	0.00032	532	814
STKc_PCTAIRE_like	cd07844	2e-05	532	821
STKc_PFTAIRE2	cd07870	0.00028	532	818
STKc_PCTAIRE3	cd07871	3.3e-05	532	818
PTKc_EphR	cd05033	2.6e-75	533	811
PTKc_Src_like	cd05034	6.8e-69	533	810
PTKc_Jak_rpt2	cd05038	9.9e-67	533	811
PTKc_Csk_like	cd05039	2.7e-35	533	813
PTKc_InsR_like	cd05032	1.3e-103	533	809
PTK_Ryk	cd05043	6.1e-27	533	810
PTKc_Tec_like	cd05059	4.2e-72	533	811
PTKc_EphR_B	cd05065	4.7e-62	533	811
PTKc_EphR_A	cd05066	1.5e-68	533	811
PTKc_Jak1_rpt2	cd05079	5.3e-42	533	811
PTKc_Chk	cd05083	9.3e-58	533	810
PTKc_Itk	cd05112	2.6e-69	533	811
PTKc_Btk_Bmx	cd05113	1.1e-69	533	808
PTKc_Tec_Rlk	cd05114	3.9e-66	533	808
PKc_MKK4	cd06616	7.5e-06	533	821
STKc_MAP4K3_like	cd06613	2.2e-09	534	806
STKc_MST4	cd06640	5.8e-06	534	821
STKc_MST3	cd06641	2.4e-06	534	821
STKc_STK25-YSK1	cd06642	1.7e-06	534	822
STKc_CDKL2_3	cd07846	6.9e-06	534	821
STKc_CDKL1_4	cd07847	4.8e-05	534	821
STKc_PCTAIRE2	cd07872	0.00059	534	816
PTKc_Srm_Brk	cd05148	2.5e-62	535	810
STKc_phototropin_lik	cd05574	0.00013	535	817
STKc_MEKK2	cd06652	7.9e-07	535	808
STKc_MEKK3_like_1	cd06653	3.8e-08	535	812
STKc_CDK8_like	cd07842	1.7e-05	535	797
STKc_CDK5	cd07839	1.1e-06	535	818
STKc_ERK1_2_like	cd07849	0.00013	535	822
STKc_MPK1	cd07857	0.00062	535	820
STKc_CDK4	cd07863	0.00016	535	811
STKc_Nek6_Nek7	cd08224	1.2e-09	535	816
PTKc_Tie1	cd05089	2e-48	536	819
STKc_PKA	cd05580	4.1e-05	536	813
STKc_PDK1	cd05581	8.2e-12	536	807
STKc_PRKX_like	cd05612	2.8e-05	536	818
PKc_MAPKK	cd06605	8.6e-08	536	812
PKc_MEK	cd06615	1.2e-05	536	821
PKc_MKK3_6	cd06617	1.1e-05	536	822
PKc_MKK5	cd06619	0.00016	536	822
PKc_MAPKK_Pek1_like	cd06621	2.2e-07	536	804
STKc_MST3_like	cd06609	2.6e-09	536	818
PKc_MAPKK_PBS2_like	cd06622	1.2e-05	536	821
PKc_MAPKK_plant_like	cd06623	1e-13	536	805
STKc_MEKK3_like	cd06625	1.4e-12	536	812
STKc_MAPKKK_Bck1_lik	cd06629	7e-11	536	800
STKc_MOK	cd07831	4.6e-05	536	822
STKc_CDK1_like	cd07835	2.8e-07	536	818
STKc_Nek6	cd08228	8.9e-08	536	812
STKc_Nek7	cd08229	1.9e-09	536	812
SPS1	COG0515	3.4e-08	536	822
PTKc_RET	cd05045	7e-55	537	814
STKc_Yank1	cd05578	1.9e-08	537	818
STKc_MSK_N	cd05583	3.1e-05	537	819
STKc_GRK4_like	cd05605	9.7e-05	537	820
STKc_MSK1_N	cd05613	0.00025	537	820
STKc_MAPKKK	cd06606	1.7e-19	537	807
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-14	537	807
STKc_Cdc7_like	cd06627	1.5e-14	537	807
STKc_MEKK3	cd06651	2.3e-10	537	809
STKc_CCRK	cd07832	7.3e-10	537	799
STKc_MAPK	cd07834	2.9e-08	537	814
STKc_Pho85	cd07836	4.8e-06	537	817
STKc_CDK7	cd07841	3.8e-09	537	811
STKc_CDK2_3	cd07860	0.00015	537	818
STKc_CDK1_euk	cd07861	3.5e-05	537	818
STKc_Nek	cd08215	3.4e-17	537	809
STKc_Nek1	cd08218	9.8e-08	537	811
STKc_Nek3	cd08219	2.8e-10	537	807
STKc_Nek11	cd08222	1.6e-13	537	811
STKc_Nek4	cd08223	3.2e-11	537	811
STKc_Nek5	cd08225	7.7e-09	537	807
STKc_Nek8	cd08220	9e-07	537	811
STKc_Nek10	cd08528	2.2e-05	537	809
STKc_FA2-like	cd08529	1e-11	537	812
PTKc_Axl_like	cd05035	2.5e-62	538	811
PTKc_Axl	cd05075	4.9e-55	538	814
PTKc_Tyro3	cd05074	1e-61	538	811
STKc_CNK2-like	cd08530	1.2e-09	538	807
STKc_ROCK_NDR_like	cd05573	0.00032	539	822
STKc_MAK_like	cd07830	1.1e-10	539	807
STKc_CDK4_6_like	cd07838	1.8e-06	539	797
STKc_CDK9_like	cd07840	2.6e-12	539	821
PK_STRAD	cd08216	0.00052	539	813
PKc_STE	cd05122	1.8e-13	540	800
STKc_myosinIII_like	cd06608	3.8e-07	540	786
STKc_OSR1_SPAK	cd06610	2.9e-09	540	800
STKc_MEKK4	cd06626	4.1e-11	540	800
STKc_Nek2	cd08217	2.5e-08	540	807
STKc_RSK_N	cd05582	0.00077	541	820
STKc_NAK1_like	cd06917	1.8e-08	541	818
STKc_CDK_like	cd07829	3.3e-12	541	807
PTKc	cd00192	2.7e-142	542	808
PTKc_Ack_like	cd05040	5.2e-70	542	809
PTKc_Fes_like	cd05041	1.3e-56	542	809
PTKc_Aatyk	cd05042	2.4e-34	542	809
PTKc_c-ros	cd05044	1.7e-90	542	809
PTK_Jak_rpt1	cd05037	9e-13	542	808
PTKc_Met_Ron	cd05058	8.2e-67	542	813
PTKc_Syk_like	cd05060	3.7e-61	542	812
PTK_Jak1_rpt1	cd05077	9.6e-10	542	808
PTK_Jak2_Jak3_rpt1	cd05078	6e-13	542	808
PTKc_Fes	cd05084	4.5e-64	542	809
PTKc_Aatyk2	cd05086	7.8e-40	542	809
PTKc_Aatyk1_Aatyk3	cd05087	3.5e-46	542	809
PTKc_Syk	cd05116	3.1e-52	542	812
STKc_CMGC	cd05118	4.1e-11	542	807
STKc_PKC	cd05570	1.1e-05	542	821
STKc_nPKC_theta_delt	cd05592	0.00032	542	822
STKc_nPKC_theta	cd05619	0.00013	542	815
STKc_MEKK1_plant	cd06632	2.3e-12	542	807
STKc_MEKK1	cd06630	2.2e-07	542	808
STKc_Nek9	cd08221	2.2e-08	542	806
PTKc_Zap-70	cd05115	2.2e-53	543	812
STKc_CDKL	cd07833	1.5e-06	543	807
STKc_CdkB_plant	cd07837	1.2e-07	543	819
STKc_CDC2L1	cd07843	2.1e-06	543	818
PKc	cd00180	3e-62	544	810
PTKc_Tie	cd05047	2.4e-54	544	812
PTKc_Fer	cd05085	3.9e-54	544	809
STKc_AGC	cd05123	4.5e-09	544	817
STKc_cGK_PKG	cd05572	5.6e-08	544	814
STKc_GRK	cd05577	0.00087	544	819
STKc_MAST_like	cd05579	7.5e-09	544	805
STKc_GRK1	cd05608	0.00014	544	819
STKc_MST1_2	cd06612	7.4e-10	544	800
STKc_YSK4	cd06631	3.7e-09	544	807
LRRNT	pfam01462	5.1e-08	31	60
Pkinase	pfam00069	7.9e-43	538	810
LRRNT	smart00013	1.7e-07	31	65
LRRCT	smart00082	9.5e-09	148	195
I-set	pfam07679	6.3e-10	197	283
IG	smart00409	7.9e-14	203	284
IG_like	smart00410	7.9e-14	203	284
V-set	pfam07686	0.0008	205	283
IGc2	smart00408	4.1e-08	210	273
Pkinase_Tyr	pfam07714	1.6e-148	538	807
TyrKc	smart00219	1.1e-137	538	807
STYKc	smart00221	1.8e-59	538	809
S_TKc	smart00220	5.4e-51	548	817

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_046520	Polymorphism	p.ARG718CYS	N/A
Swiss-Prot	VAR_046519	Polymorphism	p.ARG699GLY	N/A
Swiss-Prot	VAR_011973	Polymorphism	p.ASN338TYR	N/A
Swiss-Prot	VAR_016320	Polymorphism	p.GLY309ARG	N/A
Swiss-Prot	VAR_049715	Polymorphism	p.GLY545VAL	N/A
Swiss-Prot	VAR_041470	Polymorphism	p.LEU138PHE	N/A
Swiss-Prot	VAR_046518	Polymorphism	p.MET697ILE	N/A
Swiss-Prot	VAR_065890	Disease	p.TYR706CYS	Obesity hyperphagia and developmental delay (OHPDD)
OMIM	600456.0001	Disease	p.TYR706CYS	OBESITY, HYPERPHAGIA, AND DEVELOPMENTAL DELAY

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258