Results for the protein: P45983

Results for the Protein: P45983

2507195

5599

MAPK8

NCBI, UniProt

MK08_HUMAN RecName: Full=Mitogen-activated protein kinase 8; Short=MAP kinase 8; Short=MAPK 8; AltName: Full=JNK-46; AltName: Full=Stress-activated protein kinase 1c; Short=SAPK1c; AltName: Full=Stress-activated protein kinase JNK1; AltName: Full=c-Jun N-terminal kinase 1

			0 4 0 1 3

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Swiss-Prot Protein: P45983

Identical to: NP_620637

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	0.00058	1	327
STKc_myosinIIIA	cd06638	1.4e-05	1	321
STKc_PAK6	cd06659	6e-09	1	350
STKc_JNK1	cd07875		1	364
PTKc_FAK	cd05056	1.1e-05	2	283
STKc_PAK1	cd06654	9.1e-08	2	314
STKc_TAO1	cd06635	1.2e-05	2	304
STKc_PAK4	cd06657	1.5e-06	2	345
PTKc_Musk	cd05050	0.0002	3	273
STKc_PAK5	cd06658	5.5e-07	3	344
STKc_JNK2	cd07876	1.7e-285	4	362
STKc_TAO3	cd06633	0.00057	6	313
STKc_PAK_I	cd06647	1.3e-07	7	312
STKc_PAK_II	cd06648	4.1e-10	7	334
STKc_PAK3	cd06656	1.5e-07	7	309
STKc_JNK3	cd07874		8	362
STKc_p38alpha_MAPK14	cd07877	6.3e-121	8	365
PTKc_FGFR1	cd05098	0.00041	9	274
STKc_ASK	cd06624	1e-07	9	275
STKc_myosinIIIB	cd06639	1.1e-05	9	267
STKc_JNK	cd07850	1.4e-289	9	360
STKc_p38	cd07851	1.7e-153	10	365
STKc_p38beta_MAPK11	cd07878	2.5e-129	10	365
STKc_p38delta_MAPK13	cd07879	2.8e-123	10	365
STKc_p38gamma_MAPK12	cd07880	1.5e-119	10	365
PTKc_FGFR2	cd05101	0.00068	11	309
STKc_PAK	cd06614	4.2e-18	11	337
PTKc_EGFR_like	cd05057	0.00039	12	281
PKc_MKK7	cd06618	8.1e-08	12	292
STKc_TAO2	cd06634	4.7e-06	12	305
STKc_PAK2	cd06655	6.5e-08	12	315
PTKc_Abl	cd05052	5e-06	13	275
PTKc_Lck_Blk	cd05067	5.9e-05	13	301
PTKc_Frk_like	cd05068	6.5e-08	13	274
PTKc_Lyn	cd05072	3.7e-05	13	278
PTKc_Hck	cd05073	0.00034	13	278
PTKc_Src_like	cd05034	1.8e-07	14	278
PTKc_EphR_A2	cd05063	1.4e-05	14	275
PTKc_EphR_A10	cd05064	0.00011	14	302
PTKc_Tec_Rlk	cd05114	4.6e-05	15	279
STKc_Sty1_Hog1	cd07856	2.4e-93	15	359
PTKc_FGFR3	cd05100	0.00086	16	319
STKc_MST4	cd06640	0.00071	16	325
STKc_CDK9	cd07865	1.5e-18	16	321
PTKc_FGFR4	cd05099	3e-05	17	299
STKc_TAO	cd06607	1e-06	17	295
PTKc_Jak_rpt2	cd05038	6.8e-07	18	282
STKc_MAP4K3	cd06645	4.3e-05	18	320
STKc_CDK10	cd07845	3.9e-22	18	335
PTKc_ALK_LTK	cd05036	7.2e-06	19	276
STKc_PCTAIRE2	cd07872	3.8e-20	19	343
STKc_PCTAIRE1	cd07873	1.9e-26	19	339
PTKc_InsR_like	cd05032	2.4e-06	20	262
PTKc_Ror	cd05048	2.4e-05	20	259
PTKc_Yes	cd05069	0.00029	20	274
PTKc_Src	cd05071	0.00031	20	276
PTKc_Chk	cd05083	9.6e-05	20	277
PTKc_Tie2	cd05088	0.00018	20	306
PTKc_EGFR	cd05108	0.0004	20	318
PTKc_HER2	cd05109	0.0001	20	281
PKc_MKK4	cd06616	6.5e-08	20	298
STKc_STK10_LOK	cd06644	2.1e-05	20	296
STKc_SLK	cd06643	8.9e-05	20	291
STKc_PCTAIRE_like	cd07844	5.5e-48	20	321
STKc_ERK1_2_like	cd07849	1.3e-105	20	362
STKc_MAPK4_6	cd07854	3.3e-38	20	360
STKc_ERK5	cd07855	1e-97	20	359
STKc_TEY_MAPK_plant	cd07858	1.8e-106	20	365
STKc_PFTAIRE1	cd07869	4.1e-18	20	328
STKc_PFTAIRE2	cd07870	7.7e-26	20	321
STKc_PCTAIRE3	cd07871	4.8e-26	20	321
PTKc_EphR	cd05033	4.5e-06	21	275
PTKc_Trk	cd05049	3.3e-05	21	254
PTKc_Csk	cd05082	0.00068	21	269
PTKc_Btk_Bmx	cd05113	6e-06	21	279
STKc_MAP4K5	cd06646	0.0002	21	275
STKc_MAPK15	cd07852	1.7e-59	21	360
STKc_CDK12	cd07864	3.8e-23	21	321
STKc_BUR1	cd07866	9.4e-22	21	321
STKc_MST1_2	cd06612	1.2e-10	22	249
STKc_MAP4K3_like	cd06613	7.5e-11	22	264
PTKc_FGFR	cd05053	3.4e-05	23	268
PTKc_EphR_B	cd05065	6.5e-05	23	275
STKc_myosinIII_like	cd06608	1.3e-08	23	224
PKc_MEK2	cd06649	9.5e-05	23	339
PKc_MEK1	cd06650	0.00011	23	350
STKc_CDC2L6	cd07867	1.4e-12	23	321
STKc_CDK8	cd07868	5.8e-12	23	321
STKc_Nek6_Nek7	cd08224	5.8e-10	23	287
STKc_Nek6	cd08228	2.1e-08	23	289
STKc_Nek7	cd08229	1.8e-10	23	277
PTKc_EphR_A	cd05066	0.00018	24	275
PTKc_Tyk2_rpt2	cd05080	0.00033	24	283
PTKc_Jak2_Jak3_rpt2	cd05081	7.1e-05	24	275
PTKc_Itk	cd05112	1.1e-05	24	279
PTKc_Srm_Brk	cd05148	4.7e-08	24	277
STKc_ROCK_NDR_like	cd05573	1.5e-08	24	390
STKc_phototropin_lik	cd05574	2.9e-05	24	345
STKc_PDK1	cd05581	1.7e-14	24	321
STKc_PKA	cd05580	1.7e-05	24	274
STKc_DMPK_like	cd05597	6.7e-05	24	345
STKc_LATS	cd05598	1.4e-05	24	325
STKc_CRIK	cd05601	1.3e-05	24	384
STKc_MAST	cd05609	7.2e-06	24	331
STKc_PRKX_like	cd05612	1.7e-06	24	353
STKc_MRCK_beta	cd05624	0.00028	24	326
STKc_LATS1	cd05625	0.00044	24	361
STKc_NDR1	cd05628	0.00053	24	329
STKc_MRCK_alpha	cd05623	0.00018	24	346
PKc_MAPKK	cd06605	1.3e-10	24	327
STKc_MST3_like	cd06609	1.2e-08	24	267
STKc_OSR1_SPAK	cd06610	1.9e-11	24	321
PKc_MEK	cd06615	7.5e-08	24	337
PKc_MKK3_6	cd06617	3.2e-08	24	299
PKc_MKK5	cd06619	0.00033	24	346
PKc_MAPKK_Pek1_like	cd06621	1.9e-06	24	324
PKc_MAPKK_PBS2_like	cd06622	2e-05	24	360
PKc_MAPKK_plant_like	cd06623	5.7e-13	24	327
STKc_MEKK3_like	cd06625	2e-11	24	280
STKc_MST3	cd06641	0.00028	24	305
STKc_MEKK2	cd06652	1.9e-06	24	277
STKc_MEKK3_like_1	cd06653	8.4e-08	24	276
STKc_NAK1_like	cd06917	1.6e-05	24	302
STKc_CDKL	cd07833	1.2e-21	24	321
STKc_CdkB_plant	cd07837	6.8e-36	24	322
STKc_CDKL2_3	cd07846	5.1e-30	24	321
STKc_CDKL1_4	cd07847	8.6e-44	24	321
STKc_CDKL5	cd07848	1.5e-24	24	321
STKc_CDC2L1	cd07843	2.8e-23	24	321
STKc_CDK6	cd07862	5.1e-31	24	321
SPS1	COG0515	2.8e-54	24	423
PKc_STE	cd05122	4.5e-19	25	320
STKc_Yank1	cd05578	6.8e-10	25	321
STKc_MSK_N	cd05583	8.2e-05	25	338
STKc_cPKC	cd05587	1.4e-05	25	359
STKc_GRK4_like	cd05605	8.4e-09	25	327
STKc_MSK1_N	cd05613	0.00072	25	295
STKc_MSK2_N	cd05614	0.00062	25	376
STKc_cPKC_alpha	cd05615	0.00017	25	322
STKc_cPKC_beta	cd05616	0.00041	25	359
STKc_GRK6	cd05630	1.4e-05	25	327
STKc_GRK4	cd05631	1.4e-05	25	297
STKc_GRK5	cd05632	2.7e-06	25	306
STKc_MAPKKK	cd06606	3.1e-20	25	321
PKc_MAPKK_Byr1_like	cd06620	4.7e-06	25	317
STKc_MEKK4	cd06626	6e-11	25	321
STKc_Cdc7_like	cd06627	6.4e-12	25	321
STKc_MAPKKK_Byr2_lik	cd06628	4.1e-08	25	275
STKc_MEKK1	cd06630	1.5e-06	25	276
STKc_YSK4	cd06631	6.1e-08	25	280
STKc_MEKK1_plant	cd06632	2.3e-10	25	321
STKc_MEKK3	cd06651	1.2e-07	25	278
STKc_CCRK	cd07832	5.9e-45	25	322
STKc_MAPK	cd07834	3.7e-189	25	359
STKc_Pho85	cd07836	2.4e-49	25	321
STKc_CDK5	cd07839	1.5e-37	25	321
STKc_CDK7	cd07841	4.1e-31	25	338
STKc_CDK8_like	cd07842	2.1e-22	25	321
STKc_NLK	cd07853	1.6e-67	25	387
STKc_MPK1	cd07857	5.9e-92	25	360
STKc_TDY_MAPK_plant	cd07859	3.3e-71	25	365
STKc_CDK2_3	cd07860	1.1e-52	25	321
STKc_CDK1_euk	cd07861	1.7e-50	25	321
STKc_CDK4	cd07863	4.7e-43	25	321
STKc_Nek	cd08215	3e-18	25	321
STKc_Nek2	cd08217	1.9e-11	25	321
STKc_Nek1	cd08218	1.1e-08	25	280
STKc_Nek3	cd08219	4.2e-12	25	279
STKc_Nek8	cd08220	1.4e-07	25	275
STKc_Nek9	cd08221	5e-11	25	276
STKc_Nek11	cd08222	5.1e-08	25	279
STKc_Nek4	cd08223	7.2e-07	25	279
STKc_Nek5	cd08225	9.3e-12	25	279
STKc_Nek10	cd08528	5.3e-08	25	277
STKc_FA2-like	cd08529	2.7e-08	25	256
STKc_CNK2-like	cd08530	6.6e-10	25	278
PTKc_Tie1	cd05089	0.001	26	326
STKc_CMGC	cd05118	8.7e-191	26	321
STKc_PKN	cd05589	9.4e-06	26	326
STKc_TNIK	cd06637	0.00019	26	266
STKc_CDK_like	cd07829	2.1e-53	26	321
STKc_MAK_like	cd07830	3e-25	26	321
STKc_MOK	cd07831	2.7e-30	26	321
STKc_CDK1_like	cd07835	9.2e-51	26	321
STKc_CDK4_6_like	cd07838	1.8e-24	26	321
STKc_CDK9_like	cd07840	1.8e-35	26	321
PTKc_Tec_like	cd05059	8e-07	29	279
STKc_RSK_N	cd05582	7.1e-06	29	349
STKc_p70S6K	cd05584	4.5e-06	29	328
STKc_Rim15_like	cd05611	5.4e-05	29	326
STKc_SLK_like	cd06611	2.3e-05	29	300
PTKc	cd00192	9.8e-10	30	275
PTKc_Ack_like	cd05040	6e-06	30	277
PTKc_Fes_like	cd05041	1e-05	30	275
PTKc_c-ros	cd05044	4.6e-05	30	276
PTKc_Met_Ron	cd05058	0.00042	30	284
PTKc_Syk_like	cd05060	3e-05	30	280
PTKc_Fes	cd05084	1.7e-06	30	276
PTKc_Fer	cd05085	5.5e-06	30	275
PTKc_Syk	cd05116	8.4e-05	30	280
STKc_PKC	cd05570	2.4e-06	30	300
STKc_PKB	cd05571	4.8e-07	30	360
STKc_SGK	cd05575	4.1e-05	30	326
STKc_aPKC	cd05588	2.5e-05	30	359
STKc_nPKC_eta	cd05590	0.00014	30	359
STKc_nPKC_epsilon	cd05591	9.5e-05	30	322
STKc_nPKC_theta_delt	cd05592	2.2e-06	30	323
STKc_PKB_gamma	cd05593	9.1e-05	30	380
STKc_PKB_alpha	cd05594	2.6e-05	30	358
STKc_PKB_beta	cd05595	7.9e-05	30	360
STKc_SGK2	cd05603	1.7e-05	30	322
STKc_SGK3	cd05604	0.00035	30	334
STKc_SGK1	cd05602	7.6e-05	30	360
STKc_aPKC_zeta	cd05617	0.00025	30	354
STKc_nPKC_theta	cd05619	1.1e-06	30	327
STKc_aPKC_iota	cd05618	0.00055	30	354
PKc	cd00180	2.8e-60	32	319
PTKc_Tie	cd05047	0.00086	32	276
PTKc_Zap-70	cd05115	0.00015	32	280
STKc_AGC	cd05123	3.9e-13	32	321
STKc_cGK_PKG	cd05572	1e-08	32	273
STKc_GRK	cd05577	3.7e-08	32	339
STKc_MAST_like	cd05579	6.1e-10	32	324
STKc_YPK1_like	cd05585	8.3e-07	32	325
STKc_beta_ARK	cd05606	0.00065	32	300
STKc_GRK7	cd05607	7.2e-08	32	328
STKc_GRK1	cd05608	1.6e-07	32	323
STKc_Sck1_like	cd05586	4.6e-06	32	413
STKc_MAPKKK_Bck1_lik	cd06629	5.4e-07	32	249
STKc_Sid2p_Dbf2p	cd05600	3.9e-05	59	389
Pkinase	pfam00069	3.3e-70	26	321
Pkinase_Tyr	pfam07714	7.9e-12	26	278
TyrKc	smart00219	6.8e-12	26	260
STYKc	smart00221	7.4e-84	26	321
S_TKc	smart00220	2.3e-105	36	321

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_050592	Polymorphism	p.GLU365LYS	N/A
Swiss-Prot	VAR_042259	Polymorphism	p.GLY177ARG	N/A
Swiss-Prot	VAR_042258	Polymorphism	p.GLY171SER	N/A
dbSNP	rs28395809	Polymorphism	p.THR367ALA	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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