Results for the protein: P00749

Results for the Protein: P00749

254763341

5328

PLAU

NCBI, UniProt

UROK_HUMAN RecName: Full=Urokinase-type plasminogen activator; Short=U-plasminogen activator; Short=uPA; Contains: RecName: Full=Urokinase-type plasminogen activator long chain A; Contains: RecName: Full=Urokinase-type plasminogen activator short chain A; Contains: RecName: Full=Urokinase-type plasminogen activator chain B; Flags: Precursor

Known Diseases associated with this Protein:
ALZHEIMER DISEASE, LATE-ONSET, SUSCEPTIBILITY TO

1

5

1

2

3

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Default View: KR - cd00108 KR - smart00130 Kringle - pfam00051 Tryp_SPc - smart00020 Tryp_SPc - cd00190 Trypsin - pfam00089	Swiss-Prot Protein: P00749 Identical to: NP_002649 Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Tryp_SPc	cd00190	8.1e-105	179	422
Kringle	pfam00051	1.4e-37	70	151
Trypsin	pfam00089	6.8e-98	179	419
KR	smart00130	4.6e-36	68	153
Tryp_SPc	smart00020	9.8e-92	178	419

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_013102	Polymorphism	p.ILE214MET	N/A
dbSNP	rs2227564	Polymorphism	p.LEU141PRO	N/A
dbSNP	rs2227567	Polymorphism	p.LYS231GLN	N/A
Swiss-Prot	VAR_006722	Polymorphism	p.PRO141LEU	N/A
Swiss-Prot	VAR_038730	Polymorphism	p.VAL15LEU	N/A
OMIM	191840.0001	Disease	p.PRO141LEU	ALZHEIMER DISEASE, LATE-ONSET, SUSCEPTIBILITY TO

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258