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Results for the Protein: Q9UM73
296439447
238
ALK

ALK_HUMAN RecName: Full=ALK tyrosine kinase receptor; AltName: Full=Anaplastic lymphoma kinase; AltName: CD_antigen=CD246; Flags: Precursor

Known Diseases associated with this Protein:
  NEUROBLASTOMA 3 (NBLST3)
  NEUROBLASTOMA, SUSCEPTIBILITY TO, 3
20
23
4
4
35
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

MAM - cd06263
MAM - pfam00629
PTKc_CSF-1R - cd05106
PTKc_PDGFR_alpha - cd05105
PTKc_PDGFR_beta - cd05107
PTKc_Kit - cd05104
PTKc_PDGFR - cd05055
STKc_TAO1 - cd06635
STKc_PAK1 - cd06654
STKc_PAK_I - cd06647
STKc_PAK2 - cd06655
STKc_PAK3 - cd06656
STKc_myosinIIIB - cd06639
STKc_myosinIIIA - cd06638
STKc_BUR1 - cd07866
STKc_PAK6 - cd06659
PKc_MKK7 - cd06618
PTKc_FGFR2 - cd05101
STKc_STK10_LOK - cd06644
STKc_TAO - cd06607
STKc_TAO2 - cd06634
STKc_CDK10 - cd07845
PTKc_FGFR1 - cd05098
PTKc_FGFR4 - cd05099
PTKc_HER2 - cd05109
STKc_ASK - cd06624
PTKc_HER4 - cd05110
STKc_PAK_II - cd06648
STKc_PAK - cd06614
PKc_MAPKK_plant_like - cd06623
PTKc_FGFR - cd05053
PTKc_FGFR3 - cd05100
PTK_Tyk2_rpt1 - cd05076
STKc_MAP4K3 - cd06645
STKc_MAP4K5 - cd06646
STKc_myosinIII_like - cd06608
PTKc_EGFR - cd05108
PTKc_Tie2 - cd05088
PTK_HER3 - cd05111
PTKc_EGFR_like - cd05057
STKc_CDK12 - cd07864
PTKc_FAK - cd05056
PTKc_ALK_LTK - cd05036
PTKc_Src - cd05071
PTKc_TrkA - cd05092
PTKc_TrkB - cd05093
PTKc_Ror2 - cd05091
PTKc_Ror1 - cd05090
PTKc_Csk - cd05082
PTKc_EphR_A2 - cd05063
PTKc_DDR2 - cd05095
STKc_SLK - cd06643
PTKc_Srm_Brk - cd05148
STKc_SLK_like - cd06611
PTKc_Hck - cd05073
PTKc_VEGFR3 - cd05102
PTKc_VEGFR2 - cd05103
PTKc_DDR_like - cd05097
PTKc_TrkC - cd05094
PTKc_DDR1 - cd05096
PTKc_Trk - cd05049
PTKc_Src_like - cd05034
PTKc_Ror - cd05048
PTKc_DDR - cd05051
PTKc_Musk - cd05050
PTKc_Lyn - cd05072
PTKc_InsR_like - cd05032
PTKc_Csk_like - cd05039
PTKc_Abl - cd05052
PTK_CCK4 - cd05046
PTKc_Fyn_Yrk - cd05070
PTKc_Yes - cd05069
PTKc_VEGFR - cd05054
PTKc_Lck_Blk - cd05067
PTKc_Frk_like - cd05068
PTKc_EphR_A10 - cd05064
PTKc_InsR - cd05061
PTKc_IGF-1R - cd05062
PTKc_Chk - cd05083
PTKc_EphR_B - cd05065
PTKc_Btk_Bmx - cd05113
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Tec_Rlk - cd05114
PTKc_Itk - cd05112
PTKc_EphR_A - cd05066
PTKc_Jak_rpt2 - cd05038
PTKc_EphR - cd05033
PTKc_Tyk2_rpt2 - cd05080
PTK_Ryk - cd05043
PTKc_Tec_like - cd05059
PTKc_Jak1_rpt2 - cd05079
STKc_PCTAIRE_like - cd07844
STKc_MST4 - cd06640
STKc_MST1_2 - cd06612
STKc_MAP4K3_like - cd06613
STKc_STK25-YSK1 - cd06642
STKc_MST3 - cd06641
PKc_MKK4 - cd06616
STKc_Nek6_Nek7 - cd08224
STKc_MEKK3_like_1 - cd06653
PKc_MAPKK_PBS2_like - cd06622
STKc_OSR1_SPAK - cd06610
STKc_Nek7 - cd08229
SPS1 - COG0515
PKc_MAPKK_Pek1_like - cd06621
STKc_Nek6 - cd08228
STKc_MEKK3_like - cd06625
STKc_PDK1 - cd05581
STKc_PKA - cd05580
PKc_MKK3_6 - cd06617
STKc_PRKX_like - cd05612
PTKc_Tie1 - cd05089
PKc_MAPKK - cd06605
STKc_MST3_like - cd06609
STKc_Nek11 - cd08222
STKc_Nek8 - cd08220
STKc_Nek4 - cd08223
STKc_Nek9 - cd08221
STKc_Nek5 - cd08225
STKc_Nek3 - cd08219
STKc_CNK2-like - cd08530
STKc_Nek10 - cd08528
STKc_Nek1 - cd08218
STKc_MEKK3 - cd06651
STKc_GRK4_like - cd05605
STKc_Nek - cd08215
STKc_Yank1 - cd05578
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
STKc_CDK7 - cd07841
PTKc_RET - cd05045
STKc_CCRK - cd07832
STKc_MAPK - cd07834
TyrKc - smart00219
Pkinase - pfam00069
STYKc - smart00221
Pkinase_Tyr - pfam07714
PTKc_Tyro3 - cd05074
PTKc_Axl_like - cd05035
STKc_MAPKKK_Bck1_lik - cd06629
PTKc_Axl - cd05075
STKc_PKN - cd05589
STKc_CDK_like - cd07829
PKc_STE - cd05122
STKc_MAPKKK_Byr2_lik - cd06628
STKc_NAK1_like - cd06917
STKc_MAK_like - cd07830
STKc_CMGC - cd05118
STKc_YSK4 - cd06631
STKc_CDK9_like - cd07840
STKc_MOK - cd07831
STKc_Nek2 - cd08217
STKc_RSK_N - cd05582
STKc_FA2-like - cd08529
PTKc_Syk - cd05116
STKc_nPKC_theta_delt - cd05592
STKc_MEKK1_plant - cd06632
PTKc_Aatyk1_Aatyk3 - cd05087
STKc_MEKK4 - cd06626
STKc_nPKC_theta - cd05619
STKc_nPKC_epsilon - cd05591
PTKc_Aatyk2 - cd05086
PTK_Jak_rpt1 - cd05037
PTKc_Fes_like - cd05041
PTKc_Ack_like - cd05040
PTKc_Aatyk - cd05042
PTKc - cd00192
PTKc_c-ros - cd05044
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Fes - cd05084
PTK_Jak1_rpt1 - cd05077
PTKc_Syk_like - cd05060
PTKc_Met_Ron - cd05058
PTKc_Zap-70 - cd05115
STKc_MEKK1 - cd06630
PTKc_Fer - cd05085
PTKc_Tie - cd05047
PKc - cd00180
STKc_GRK7 - cd05607
STKc_AGC - cd05123
STKc_cGK_PKG - cd05572
STKc_GRK - cd05577
S_TKc - smart00220


Swiss-Prot Protein: Q9UM73
Identical to: NP_004295
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
MAMcd062638.2e-28266425
MAMcd062631.4e-31480634
PTKc_CSF-1Rcd051067.3e-4110751388
PTKc_PDGFR_alphacd051058.4e-1710781389
PTKc_PDGFR_betacd051078.8e-1110781388
PTKc_Kitcd051049.3e-3110821387
PTKc_PDGFRcd050554.9e-2410881387
STKc_TAO1cd066351.1e-0510941427
STKc_PAK1cd066544.7e-0510941408
STKc_PAK_Icd066475.1e-0510951406
STKc_PAK3cd066563.2e-0510951410
STKc_PAK2cd066557.6e-0510951409
STKc_myosinIIIAcd066382.4e-0510961385
STKc_myosinIIIBcd066391.9e-0510961384
STKc_BUR1cd078660.0003310981402
STKc_PAK6cd066595.9e-0710991415
PKc_MKK7cd066182.5e-0811001395
PTKc_FGFR2cd051016.1e-5011011391
STKc_STK10_LOKcd066441.8e-0511011413
STKc_TAOcd066075.2e-0511021427
STKc_TAO2cd066347.9e-0711021428
STKc_CDK10cd078458.8e-0611031415
PTKc_FGFR1cd050981.1e-5211041391
PTKc_FGFR4cd050999.9e-6011041404
PTKc_HER2cd051096.2e-3911051394
PTKc_HER4cd051103.2e-2311051409
STKc_ASKcd066243.2e-0611051385
PTKc_FGFRcd050534.7e-7511061388
PTK_Tyk2_rpt1cd050763.7e-0611061384
PTKc_FGFR3cd051004.1e-5011061423
PKc_MAPKK_plant_likecd066231.9e-1011061385
STKc_PAKcd066149.1e-0911061405
STKc_PAK_IIcd066484.7e-0511061397
STKc_MAP4K3cd066453e-0511071384
PTKc_EGFR_likecd050574.4e-5111081394
PTKc_Tie2cd050883.9e-3611081408
PTKc_EGFRcd051084.8e-2911081422
PTK_HER3cd051111.6e-2411081394
STKc_myosinIII_likecd066084.5e-0611081383
STKc_MAP4K5cd066462e-0511081384
PTKc_ALK_LTKcd050366.7e-24011091385
PTKc_FAKcd050563.3e-6411091391
STKc_CDK12cd078641.7e-0611091405
PTKc_InsR_likecd050321.1e-10411101385
PTKc_Csk_likecd050391.6e-5511101386
PTK_CCK4cd050462.3e-5411101385
PTKc_Trkcd050492.2e-9011101385
PTKc_Muskcd050503.8e-8211101385
PTKc_Src_likecd050343.6e-6511101385
PTKc_Rorcd050484.7e-7611101386
PTKc_DDRcd050511.8e-5711101382
PTKc_Ablcd050526.4e-6911101387
PTKc_VEGFRcd050542.1e-2711101390
PTKc_InsRcd050618.7e-8311101397
PTKc_IGF-1Rcd050622.8e-9011101385
PTKc_EphR_A10cd050642.7e-4811101387
PTKc_Lck_Blkcd050675.3e-5211101386
PTKc_Frk_likecd050682.9e-7211101386
PTKc_Yescd050691.4e-4711101386
PTKc_Fyn_Yrkcd050704.6e-5411101386
PTKc_Lyncd050725.9e-5211101386
PTKc_Hckcd050731.5e-4811101386
PTKc_Cskcd050823.3e-5411101386
PTKc_EphR_A2cd050635e-5411101387
PTKc_Ror1cd050905.6e-6411101386
PTKc_Ror2cd050914.1e-4911101386
PTKc_Srccd050713.4e-4711101387
PTKc_TrkAcd050923.5e-7611101396
PTKc_TrkBcd050931.6e-6811101395
PTKc_DDR2cd050951.5e-5011101385
PTKc_DDR1cd050965.6e-4211101385
PTKc_DDR_likecd050971.7e-5411101385
PTKc_TrkCcd050944.9e-4811101395
PTKc_VEGFR2cd051031.3e-2511101390
PTKc_VEGFR3cd051022.6e-3711101390
PTKc_Srm_Brkcd051484.3e-5811101386
STKc_SLK_likecd066114.4e-0711101400
STKc_SLKcd066431.8e-0611101410
PTKc_EphRcd050334.5e-6411111387
PTKc_Jak_rpt2cd050381.2e-4511111387
PTK_Rykcd050434.3e-2411111380
PTKc_Tec_likecd050593.3e-6911111384
PTKc_EphR_Acd050666.9e-5511111387
PTKc_Jak1_rpt2cd050791.8e-1911111387
PTKc_Tyk2_rpt2cd050804.5e-1511111387
PTKc_Jak2_Jak3_rpt2cd050813.5e-2111111387
PTKc_Chkcd050837.7e-6311111386
PTKc_EphR_Bcd050654.9e-5011111387
PTKc_Itkcd051121.8e-6311111384
PTKc_Btk_Bmxcd051131e-6611111384
PTKc_Tec_Rlkcd051142.3e-6511111384
STKc_MST1_2cd066127.9e-0611121357
STKc_MAP4K3_likecd066131.8e-0911121384
STKc_MST3cd066411.9e-0511121397
STKc_STK25-YSK1cd066421.6e-0611121412
STKc_MST4cd066407.4e-0511121397
STKc_PCTAIRE_likecd078440.00111121416
PKc_MKK4cd066161.9e-0511131400
STKc_MEKK3_like_1cd066533.5e-0511131386
STKc_Nek6_Nek7cd082241.2e-0511131388
PTKc_Tie1cd050893.8e-4211141407
STKc_PKAcd055800.0003811141398
STKc_PDK1cd055811.5e-0811141376
STKc_PRKX_likecd056120.000611141429
PKc_MAPKKcd066054.9e-0611141385
STKc_MST3_likecd066098.1e-0911141397
PKc_MKK3_6cd066178.4e-0611141401
PKc_MAPKK_Pek1_likecd066213.5e-0711141385
STKc_OSR1_SPAKcd066101.2e-0811141385
STKc_MEKK3_likecd066258.3e-0811141385
PKc_MAPKK_PBS2_likecd066221.2e-0611141418
STKc_Nek7cd082293e-0611141388
STKc_Nek6cd082284.2e-0511141388
SPS1COG05155.4e-2511141568
PTKc_RETcd050452.2e-4911151390
STKc_Yank1cd055782.4e-0511151379
STKc_GRK4_likecd056051.9e-0511151429
STKc_MAPKKKcd066062.3e-1811151377
STKc_Cdc7_likecd066275.1e-0911151376
STKc_MEKK3cd066514.2e-0511151379
STKc_CCRKcd078328.2e-0511151353
STKc_CDK7cd078418.3e-0511151398
STKc_MAPKcd078340.000411151408
STKc_Nekcd082151.2e-1011151385
STKc_Nek3cd082199.7e-1011151385
STKc_Nek8cd082207.2e-0511151367
STKc_Nek9cd082215.9e-0611151385
STKc_Nek11cd082224.8e-0611151386
STKc_Nek4cd082232.1e-0611151386
STKc_Nek1cd082180.0001611151385
STKc_Nek5cd082251.4e-0611151385
STKc_Nek10cd085284.3e-0511151385
STKc_CNK2-likecd085303.9e-0611151385
PTKc_Axl_likecd050351.6e-7111161387
PTKc_Tyro3cd050745.2e-6511161387
PTKc_Axlcd050751.1e-5911161387
STKc_PKNcd055897.7e-0511161447
STKc_MAPKKK_Bck1_likcd066291.9e-0811161386
STKc_CMGCcd051189.6e-0611171376
PKc_STEcd051229e-1211171376
STKc_MAPKKK_Byr2_likcd066283.3e-0811171385
STKc_YSK4cd066317.2e-0911171386
STKc_NAK1_likecd069172.5e-0711171397
STKc_MAK_likecd078305.5e-0511171385
STKc_CDK_likecd078296.9e-0711171376
STKc_CDK9_likecd078407.1e-0711181402
STKc_MOKcd078310.0007211181386
STKc_Nek2cd082173.5e-0611181385
STKc_RSK_Ncd055820.0002711191456
STKc_FA2-likecd085291.5e-0611191383
PTKccd001922.7e-12611201384
PTK_Jak_rpt1cd050371.1e-1211201384
PTKc_Fes_likecd050413.2e-7611201385
PTKc_Ack_likecd050404.9e-5011201385
PTKc_Aatykcd050421.1e-2011201385
PTKc_c-roscd050443e-11611201385
PTKc_Met_Roncd050584.9e-6511201389
PTKc_Syk_likecd050608.1e-6011201388
PTK_Jak1_rpt1cd050776e-0911201384
PTK_Jak2_Jak3_rpt1cd050783e-1111201384
PTKc_Fescd050842.4e-7811201385
PTKc_Aatyk2cd050865.4e-2011201385
PTKc_Aatyk1_Aatyk3cd050874.6e-3811201385
PTKc_Sykcd051161.5e-4311201387
STKc_nPKC_epsiloncd055910.0003911201460
STKc_nPKC_theta_deltcd055929.5e-0511201441
STKc_nPKC_thetacd056190.0002411201441
STKc_MEKK4cd066266e-0711201377
STKc_MEKK1_plantcd066322.3e-0811201381
PTKc_Zap-70cd051151.8e-4411211388
PKccd001806.9e-5211221383
PTKc_Tiecd050474e-4711221388
PTKc_Fercd050856.5e-7111221385
STKc_AGCcd051234.7e-0711221376
STKc_cGK_PKGcd055720.000111221383
STKc_GRKcd055770.0001611221395
STKc_GRK7cd056070.0001211221395
STKc_MEKK1cd066301.2e-0611221382
MAMpfam006294.5e-30480636
Pkinasepfam000695.6e-2611161383
Pkinase_Tyrpfam077143.2e-14211161383
TyrKcsmart002194.6e-14311161383
STYKcsmart002212.3e-4711161447
S_TKcsmart002201e-3011261385

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs61744521 Polymorphismp.ALA613PRON/A
Swiss-ProtVAR_041484Polymorphismp.ALA877SERN/A
Swiss-ProtVAR_063860Diseasep.ALA1234THRNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_041487Polymorphismp.ALA1274THRN/A
Swiss-ProtVAR_041483Polymorphismp.ALA704THRN/A
Swiss-ProtVAR_063865Diseasep.ARG1275GLNNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063864Polymorphismp.ARG1275LEUN/A
Swiss-ProtVAR_063859Diseasep.ARG1192PRONeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063850Diseasep.ASP1091ASNNeuroblastoma 3 (NBLST3)
dbSNPrs1881421 Polymorphismp.ASP1529GLUN/A
Swiss-ProtVAR_041491Polymorphismp.GLN1429ARGN/A
Swiss-ProtVAR_041479Polymorphismp.GLU296GLNN/A
Swiss-ProtVAR_041490Polymorphismp.GLU1419LYSN/A
Swiss-ProtVAR_063851Diseasep.GLY1128ALANeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_041486Polymorphismp.GLY1121ASPN/A
Swiss-ProtVAR_063854Diseasep.ILE1171ASNNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063863Diseasep.ILE1250THRNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_031042Polymorphismp.ILE1461VALN/A
Swiss-ProtVAR_061288Polymorphismp.LEU868GLNN/A
Swiss-ProtVAR_041481Polymorphismp.LEU560PHEN/A
dbSNPrs1881420 Polymorphismp.LYS1491ARGN/A
Swiss-ProtVAR_041489Polymorphismp.LYS1416ASNN/A
Swiss-ProtVAR_063853Diseasep.MET1166ARGNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_041488Polymorphismp.MET1328LEUN/A
Swiss-ProtVAR_063855Diseasep.PHE1174CYSNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063861Diseasep.PHE1245CYSNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063856Diseasep.PHE1174ILENeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063857Diseasep.PHE1174LEUNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_055987Polymorphismp.PHE1376SERN/A
Swiss-ProtVAR_063858Diseasep.PHE1174VALNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063862Diseasep.PHE1245VALNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_055988Polymorphismp.PRO1599HISN/A
Swiss-ProtVAR_041477Polymorphismp.SER90LEUN/A
Swiss-ProtVAR_041482Polymorphismp.THR680ILEN/A
Swiss-ProtVAR_041485Polymorphismp.THR1012METN/A
Swiss-ProtVAR_063852Diseasep.THR1151METNeuroblastoma 3 (NBLST3)
Swiss-ProtVAR_063866Diseasep.TYR1278SERNeuroblastoma 3 (NBLST3)
dbSNPrs35093491 Polymorphismp.VAL476ALAN/A
Swiss-ProtVAR_041478Polymorphismp.VAL163LEUN/A
OMIM105590.0001 Diseasep.ARG1275GLNNEUROBLASTOMA, SUSCEPTIBILITY TO, 3
OMIM105590.0003 Diseasep.ARG1192PRONEUROBLASTOMA, SUSCEPTIBILITY TO, 3
OMIM105590.0002 Diseasep.GLY1128ALANEUROBLASTOMA, SUSCEPTIBILITY TO, 3
OMIM105590.0004 Diseasep.THR1151METNEUROBLASTOMA, SUSCEPTIBILITY TO, 3



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