Results for the protein: Q8TDC3

Results for the Protein: Q8TDC3

347595639

84446

BRSK1

NCBI, UniProt

BRSK1_HUMAN RecName: Full=Serine/threonine-protein kinase BRSK1; AltName: Full=Brain-selective kinase 1; AltName: Full=Brain-specific serine/threonine-protein kinase 1; Short=BR serine/threonine-protein kinase 1; AltName: Full=Serine/threonine-protein kinase SAD-B; AltName: Full=Synapses of Amphids Defective homolog 1; Short=SAD1 homolog; Short=hSAD1

			0 6 0 0 6

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Swiss-Prot Protein: Q8TDC3

Identical to: NP_115806

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK	cd05596	1.2e-08	8	356
STKc_ROCK2	cd05621	9.1e-11	8	353
STKc_ROCK1	cd05622	6.8e-09	8	357
STKc_TAO1	cd06635	1.8e-05	9	330
PTKc_FGFR1	cd05098	0.00019	11	291
STKc_PAK1	cd06654	2.3e-08	12	313
PTKc_FGFR2	cd05101	6.1e-05	14	291
STKc_myosinIIIB	cd06639	2e-07	14	286
STKc_p38beta_MAPK11	cd07878	1.4e-07	14	325
STKc_STK10_LOK	cd06644	6.3e-09	15	304
STKc_PAK2	cd06655	3e-09	16	313
STKc_myosinIIIA	cd06638	2.6e-08	17	285
STKc_p38alpha_MAPK14	cd07877	2e-07	18	328
STKc_MAP4K5	cd06646	2.6e-07	19	284
STKc_JNK	cd07850	3.1e-07	19	326
STKc_PAK	cd06614	1.8e-16	20	300
STKc_JNK2	cd07876	6.1e-07	20	316
PTKc_FGFR4	cd05099	8.2e-05	21	299
STKc_PAK_II	cd06648	3.7e-12	21	300
STKc_p38	cd07851	1.2e-09	21	344
STKc_p38delta_MAPK13	cd07879	0.0001	21	328
PTKc_DDR	cd05051	0.00097	22	281
PTKc_FGFR	cd05053	6e-05	22	287
STKc_SLK_like	cd06611	3.9e-12	22	297
PTKc_Jak2_Jak3_rpt2	cd05081	1.4e-07	23	280
PTKc_TrkB	cd05093	1.3e-05	23	287
PTKc_Tie2	cd05088	0.00089	23	311
STKc_SLK	cd06643	5.6e-09	23	304
STKc_TAO	cd06607	1.2e-05	24	322
STKc_TAO2	cd06634	4.3e-05	24	331
STKc_MAP4K4_6	cd06636	3e-06	25	285
PTKc_EphR	cd05033	2.1e-06	26	287
PKc_MKK7	cd06618	2.1e-08	26	308
STKc_ASK	cd06624	6.2e-10	26	285
STKc_MAP4K3	cd06645	3.3e-07	26	284
STKc_PAK_I	cd06647	1.4e-10	26	306
STKc_PAK3	cd06656	6.5e-09	26	315
STKc_PAK4	cd06657	1.1e-06	26	307
STKc_PAK5	cd06658	1.9e-06	26	304
STKc_PAK6	cd06659	5e-09	26	308
STKc_CDK9	cd07865	2.5e-09	26	285
STKc_PFTAIRE2	cd07870	4.4e-10	26	285
STKc_PCTAIRE3	cd07871	9.2e-10	26	285
STKc_PCTAIRE2	cd07872	1.4e-08	26	310
STKc_p38gamma_MAPK12	cd07880	4.8e-09	26	325
PTKc_InsR	cd05061	3.6e-05	27	290
PTKc_IGF-1R	cd05062	7.2e-05	27	282
PTKc_Frk_like	cd05068	4e-15	27	286
PTKc_Lyn	cd05072	1.3e-07	27	286
PTKc_Tyk2_rpt2	cd05080	7.2e-07	27	287
PTKc_Chk	cd05083	4.1e-14	27	282
PTKc_Csk	cd05082	3.2e-10	27	286
PTKc_TrkA	cd05092	7.2e-06	27	298
PTKc_TrkC	cd05094	0.00097	27	293
PTKc_EGFR	cd05108	8.1e-06	27	328
STKc_TNIK	cd06637	1.4e-07	27	285
STKc_CDK12	cd07864	8.7e-14	27	285
STKc_PFTAIRE1	cd07869	4.6e-07	27	288
PTKc_EGFR_like	cd05057	1.9e-06	28	289
PTKc_Ror2	cd05091	1.6e-05	28	284
PTKc_HER2	cd05109	2.9e-05	28	297
PTKc_HER4	cd05110	0.00013	28	314
PTK_HER3	cd05111	3.1e-07	28	289
STKc_TEY_MAPK_plant	cd07858	8.4e-11	28	337
STKc_JNK3	cd07874	2.7e-06	28	341
PTKc_ALK_LTK	cd05036	2.7e-07	29	281
STKc_Pho85	cd07836	4.6e-22	29	285
STKc_MAP4K3_like	cd06613	5.9e-12	30	284
STKc_PCTAIRE_like	cd07844	2.1e-17	30	315
STKc_BUR1	cd07866	1.3e-10	30	285
PTKc_FAK	cd05056	1.4e-08	31	291
PTKc_Tec_like	cd05059	9.1e-11	31	280
PTKc_EphR_A10	cd05064	8.7e-06	31	287
PTKc_EphR_A2	cd05063	0.00037	31	287
PTKc_EphR_B	cd05065	2e-05	31	287
PTKc_EphR_A	cd05066	6.5e-05	31	287
PTKc_Ror1	cd05090	8.8e-05	31	284
PTKc_Btk_Bmx	cd05113	2.3e-13	31	284
PTKc_Tec_Rlk	cd05114	4.4e-16	31	284
PTKc_Itk	cd05112	7.5e-13	31	284
STKc_myosinIII_like	cd06608	3.5e-10	31	285
PKc_MAPKK_Byr1_like	cd06620	7e-08	31	299
PKc_MEK1	cd06650	6.8e-05	31	346
STKc_ERK1_2_like	cd07849	2.9e-10	31	330
STKc_ERK5	cd07855	1.4e-10	31	323
STKc_CDC2L6	cd07867	0.00024	31	285
STKc_CDK8	cd07868	0.00029	31	285
STKc_Nek6_Nek7	cd08224	1.4e-10	31	281
STKc_Nek7	cd08229	1.5e-11	31	288
STKc_Nek6	cd08228	6.4e-10	31	285
PTKc_Musk	cd05050	1.8e-06	32	282
PTKc_Lck_Blk	cd05067	7.3e-06	32	299
PTKc_Yes	cd05069	3.4e-08	32	285
PTKc_Fyn_Yrk	cd05070	1.9e-07	32	285
PTKc_Src	cd05071	3.5e-07	32	287
PTKc_Hck	cd05073	3.4e-07	32	286
STKc_ROCK_NDR_like	cd05573	1.9e-16	32	362
STKc_phototropin_lik	cd05574	4.5e-14	32	305
STKc_DMPK_like	cd05597	4.7e-13	32	352
STKc_Sid2p_Dbf2p	cd05600	9.9e-10	32	358
STKc_LATS	cd05598	1.1e-09	32	360
STKc_PRKX_like	cd05612	4.5e-33	32	317
STKc_MAST	cd05609	3.3e-24	32	336
STKc_MRCK_alpha	cd05623	1.1e-09	32	348
STKc_MRCK_beta	cd05624	2.3e-09	32	345
STKc_LATS1	cd05625	3.6e-06	32	355
STKc_LATS2	cd05626	3.1e-06	32	360
STKc_NDR2	cd05627	4e-07	32	359
STKc_NDR1	cd05628	1.1e-08	32	359
STKc_NDR_like_fungal	cd05629	1.8e-07	32	356
STKc_MST3_like	cd06609	4.5e-14	32	306
STKc_OSR1_SPAK	cd06610	5.4e-14	32	285
PKc_MEK	cd06615	1.3e-08	32	323
PKc_MKK5	cd06619	3e-05	32	333
STKc_MST4	cd06640	1.3e-08	32	305
STKc_STK25-YSK1	cd06642	4.5e-10	32	306
PKc_MEK2	cd06649	1.7e-05	32	342
STKc_MEKK2	cd06652	9.9e-10	32	286
STKc_NAK1_like	cd06917	8.4e-12	32	304
STKc_CDKL	cd07833	2.4e-11	32	285
STKc_CDK10	cd07845	3.5e-10	32	310
STKc_CDKL2_3	cd07846	2.9e-10	32	285
STKc_CDKL1_4	cd07847	1.6e-17	32	315
STKc_CDKL5	cd07848	1.1e-05	32	285
STKc_MAPK4_6	cd07854	1.3e-06	32	333
STKc_CDK6	cd07862	7.1e-06	32	285
STKc_PCTAIRE1	cd07873	7.9e-08	32	293
SPS1	COG0515	9e-66	32	456
PTKc_RET	cd05045	2.7e-06	33	290
PKc_STE	cd05122	5.1e-23	33	284
STKc_Yank1	cd05578	7.9e-22	33	285
STKc_MSK_N	cd05583	2.4e-17	33	298
STKc_cPKC	cd05587	3.7e-23	33	350
STKc_GRK4_like	cd05605	1.3e-17	33	317
STKc_MSK1_N	cd05613	1.6e-10	33	298
STKc_MSK2_N	cd05614	1e-15	33	344
STKc_cPKC_alpha	cd05615	3.1e-11	33	333
STKc_cPKC_beta	cd05616	8.9e-10	33	333
STKc_GRK6	cd05630	8.2e-09	33	294
STKc_GRK4	cd05631	1.7e-08	33	300
STKc_GRK5	cd05632	4.6e-09	33	300
STKc_MAPKKK	cd06606	1.9e-35	33	285
STKc_Cdc7_like	cd06627	2.1e-19	33	285
STKc_MAPKKK_Byr2_lik	cd06628	4.7e-30	33	285
STKc_YSK4	cd06631	7.6e-10	33	285
STKc_MEKK3	cd06651	1.9e-14	33	287
STKc_CCRK	cd07832	6.1e-18	33	286
STKc_MAPK	cd07834	1.1e-13	33	352
STKc_CDK7	cd07841	4.9e-17	33	300
STKc_CDK8_like	cd07842	6.2e-09	33	285
STKc_NLK	cd07853	1.1e-08	33	367
STKc_MPK1	cd07857	1.4e-08	33	323
STKc_TDY_MAPK_plant	cd07859	1.1e-08	33	359
STKc_CDK4	cd07863	1.3e-08	33	285
STKc_Nek	cd08215	1.7e-45	33	285
STKc_Nek2	cd08217	4.7e-17	33	285
STKc_Nek1	cd08218	5.6e-22	33	285
STKc_Nek3	cd08219	6.1e-19	33	285
STKc_Nek8	cd08220	1.9e-24	33	285
STKc_Nek9	cd08221	3.3e-13	33	285
STKc_Nek4	cd08223	8.7e-19	33	285
STKc_Nek5	cd08225	2.7e-21	33	285
STKc_FA2-like	cd08529	7.4e-14	33	279
STKc_CNK2-like	cd08530	2.2e-13	33	285
STKc_Nek10	cd08528	4.8e-09	33	285
PTKc_Axl_like	cd05035	0.00018	34	287
PTKc_Jak_rpt2	cd05038	1.9e-10	34	287
PTKc_Abl	cd05052	2.3e-09	34	287
PTKc_Tyro3	cd05074	1.2e-05	34	287
PTKc_Tie1	cd05089	3.5e-05	34	316
STKc_CMGC	cd05118	1.1e-16	34	285
PTKc_Srm_Brk	cd05148	3.4e-08	34	279
STKc_PKA	cd05580	6.4e-21	34	332
STKc_PDK1	cd05581	4.1e-33	34	285
STKc_PKN	cd05589	4.5e-13	34	353
STKc_CRIK	cd05601	3.5e-10	34	324
STKc_MST1_2	cd06612	5.2e-13	34	285
PKc_MAPKK_plant_like	cd06623	7.4e-18	34	293
STKc_MEKK3_like	cd06625	9.6e-26	34	285
STKc_MST3	cd06641	5e-09	34	286
STKc_MEKK3_like_1	cd06653	4.5e-14	34	285
STKc_CDK_like	cd07829	6.9e-20	34	285
STKc_MAK_like	cd07830	9.3e-16	34	285
STKc_MOK	cd07831	2.5e-12	34	285
STKc_CDK1_like	cd07835	4.6e-22	34	285
STKc_CDK4_6_like	cd07838	2.2e-13	34	286
STKc_CDK9_like	cd07840	8.5e-15	34	285
STKc_MAPK15	cd07852	2e-11	34	324
STKc_Sty1_Hog1	cd07856	1.9e-09	34	327
STKc_CDK1_euk	cd07861	1.1e-20	34	285
STKc_CDK2_3	cd07860	7.7e-23	34	285
STKc_Nek11	cd08222	6.7e-13	34	285
PTKc_InsR_like	cd05032	5.6e-07	35	281
PTKc_Src_like	cd05034	6.7e-11	35	279
PTKc_Csk_like	cd05039	6.5e-08	35	282
PTKc_Ror	cd05048	3.5e-06	35	286
PTKc_Trk	cd05049	1.2e-06	35	281
STKc_MEKK4	cd06626	8.6e-14	35	285
STKc_CdkB_plant	cd07837	1.1e-13	35	286
STKc_CDK5	cd07839	2.5e-11	35	285
PK_STRAD	cd08216	0.00054	35	318
PTKc_Jak1_rpt2	cd05079	4.6e-05	36	286
PKc_MAPKK_PBS2_like	cd06622	5.7e-09	36	332
STKc_RSK_N	cd05582	2.9e-32	37	335
STKc_p70S6K	cd05584	7.2e-22	37	354
PKc_MKK4	cd06616	1.3e-05	37	306
PTKc	cd00192	8.6e-12	38	284
PTKc_Fes_like	cd05041	2.7e-12	38	285
PTKc_Aatyk	cd05042	0.00013	38	285
PTKc_Ack_like	cd05040	4.6e-11	38	285
PTKc_c-ros	cd05044	2.5e-05	38	285
PTKc_Tie	cd05047	5e-05	38	291
PTKc_Met_Ron	cd05058	2.9e-06	38	289
PTKc_Syk_like	cd05060	6.3e-08	38	285
PTKc_Fes	cd05084	1.3e-17	38	285
PTKc_Fer	cd05085	6.5e-13	38	285
PTKc_Aatyk2	cd05086	0.00078	38	285
PTK_Jak1_rpt1	cd05077	0.0009	38	284
PTKc_Syk	cd05116	1.9e-07	38	285
STKc_PKC	cd05570	1.8e-17	38	349
STKc_SGK	cd05575	3.1e-18	38	352
STKc_PKB	cd05571	3.3e-34	38	357
STKc_aPKC	cd05588	2.8e-15	38	350
STKc_nPKC_eta	cd05590	2.1e-24	38	351
STKc_nPKC_epsilon	cd05591	2.5e-21	38	351
STKc_nPKC_theta_delt	cd05592	2.1e-35	38	355
STKc_PKB_gamma	cd05593	2.9e-16	38	348
STKc_PKB_alpha	cd05594	2.7e-17	38	346
STKc_PKB_beta	cd05595	6.1e-21	38	357
STKc_NDR_like	cd05599	3.8e-09	38	356
STKc_SGK1	cd05602	6.9e-13	38	354
STKc_SGK2	cd05603	3.2e-17	38	353
STKc_SGK3	cd05604	1e-15	38	355
STKc_Rim15_like	cd05611	2.6e-08	38	291
STKc_aPKC_zeta	cd05617	1.2e-11	38	350
STKc_aPKC_iota	cd05618	3.4e-09	38	350
STKc_nPKC_delta	cd05620	2e-22	38	351
STKc_nPKC_theta	cd05619	3.5e-23	38	351
PKc_MAPKK	cd06605	9.1e-11	38	290
PKc_MKK3_6	cd06617	3.1e-08	38	301
PKc_MAPKK_Pek1_like	cd06621	4e-08	38	295
STKc_MEKK1_plant	cd06632	3e-13	38	285
PTKc_Zap-70	cd05115	3.2e-08	39	286
STKc_beta_ARK	cd05606	8.6e-10	39	298
STKc_GRK3	cd05633	8.6e-09	39	307
PKc	cd00180	1.6e-87	40	283
STKc_AGC	cd05123	5.8e-52	40	285
STKc_cGK_PKG	cd05572	1.6e-21	40	292
STKc_GRK	cd05577	1.8e-12	40	298
STKc_MAST_like	cd05579	6.5e-22	40	284
STKc_YPK1_like	cd05585	4.4e-28	40	348
STKc_Sck1_like	cd05586	1.2e-15	40	400
STKc_GRK7	cd05607	3e-08	40	299
STKc_GRK1	cd05608	1.5e-11	40	304
STKc_MAPKKK_Bck1_lik	cd06629	1.9e-10	41	285
STKc_MEKK1	cd06630	4.4e-10	42	286
STKc_CDC2L1	cd07843	2.2e-10	48	285
Pkinase	pfam00069	1.3e-97	34	285
Pkinase_Tyr	pfam07714	4.4e-17	34	283
TyrKc	smart00219	3.6e-15	34	283
STYKc	smart00221	8.3e-94	34	285
S_TKc	smart00220	5.6e-104	44	285

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040394	Polymorphism	p.ARG303TRP	N/A
Swiss-Prot	VAR_040396	Polymorphism	p.GLY391GLU	N/A
Swiss-Prot	VAR_040398	Polymorphism	p.GLY749SER	N/A
Swiss-Prot	VAR_040399	Polymorphism	p.PRO764ALA	N/A
Swiss-Prot	VAR_040397	Polymorphism	p.THR531ASN	N/A
Swiss-Prot	VAR_040395	Polymorphism	p.VAL319ILE	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258