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Results for the Protein: Q96J92
41688789

WNK4_HUMAN RecName: Full=Serine/threonine-protein kinase WNK4; AltName: Full=Protein kinase lysine-deficient 4; AltName: Full=Protein kinase with no lysine 4

Known Diseases associated with this Protein:
  PSEUDOHYPOALDOSTERONISM 2B (PHA2B)
  PSEUDOHYPOALDOSTERONISM, TYPE IIB
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4
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

STKc_TAO1 - cd06635
STKc_TAO3 - cd06633
STKc_PAK5 - cd06658
STKc_PAK1 - cd06654
STKc_PAK3 - cd06656
STKc_p38alpha_MAPK14 - cd07877
STKc_PAK_II - cd06648
STKc_PAK - cd06614
STKc_PAK_I - cd06647
STKc_PAK2 - cd06655
STKc_JNK2 - cd07876
STKc_PAK6 - cd06659
STKc_PAK4 - cd06657
STKc_JNK3 - cd07874
STKc_MAP4K4_6 - cd06636
STKc_myosinIIIB - cd06639
PTKc_EGFR_like - cd05057
STKc_p38beta_MAPK11 - cd07878
STKc_myosinIIIA - cd06638
STKc_JNK - cd07850
STKc_p38gamma_MAPK12 - cd07880
STKc_TAO2 - cd06634
STKc_p38 - cd07851
STKc_TAO - cd06607
STKc_CDK9 - cd07865
PKc_MKK7 - cd06618
STKc_Sty1_Hog1 - cd07856
STKc_MSK_N - cd05583
STKc_MAP4K5 - cd06646
STKc_PFTAIRE2 - cd07870
STKc_CDK10 - cd07845
STKc_BUR1 - cd07866
STKc_ASK - cd06624
PTKc_HER2 - cd05109
PTKc_EGFR - cd05108
PTKc_FGFR - cd05053
PTK_Ryk - cd05043
STKc_TNIK - cd06637
PTK_HER3 - cd05111
STKc_PFTAIRE1 - cd07869
STKc_SLK - cd06643
PTKc_FAK - cd05056
PTKc_ALK_LTK - cd05036
STKc_MST4 - cd06640
STKc_PCTAIRE_like - cd07844
STKc_STK25-YSK1 - cd06642
STKc_MST3 - cd06641
PTKc_InsR_like - cd05032
PTKc_Jak_rpt2 - cd05038
STKc_MAP4K3_like - cd06613
STKc_MAST - cd05609
PTKc_TrkB - cd05093
PTKc_TrkC - cd05094
PTKc_TrkA - cd05092
PTKc_Tie2 - cd05088
PTKc_Csk - cd05082
PTKc_Chk - cd05083
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Itk - cd05112
STKc_MAP4K3 - cd06645
STKc_TEY_MAPK_plant - cd07858
STKc_MEKK3 - cd06651
PKc_MAPKK_Byr1_like - cd06620
PTKc_Tec_Rlk - cd05114
PTKc_Btk_Bmx - cd05113
PTKc_Tyk2_rpt2 - cd05080
PTKc_IGF-1R - cd05062
PTKc_InsR - cd05061
PTKc_EphR_A2 - cd05063
PTKc_Abl - cd05052
PTKc_Musk - cd05050
PTKc_Jak1_rpt2 - cd05079
PTKc_Src_like - cd05034
PTKc_EphR_A10 - cd05064
PTKc_EphR - cd05033
PTKc_EphR_B - cd05065
PTKc_Tec_like - cd05059
PTKc_Fyn_Yrk - cd05070
PTKc_Lyn - cd05072
PTKc_Frk_like - cd05068
PTKc_EphR_A - cd05066
STKc_CdkB_plant - cd07837
STKc_CDKL1_4 - cd07847
STKc_PCTAIRE3 - cd07871
STKc_CDKL2_3 - cd07846
SPS1 - COG0515
STKc_PCTAIRE1 - cd07873
STKc_PCTAIRE2 - cd07872
STKc_ROCK_NDR_like - cd05573
STKc_CDKL - cd07833
STKc_MEKK3_like_1 - cd06653
STKc_MST3_like - cd06609
STKc_NAK1_like - cd06917
STKc_MEKK2 - cd06652
STKc_Pho85 - cd07836
STKc_Cdc7_like - cd06627
STKc_CCRK - cd07832
STKc_CDK7 - cd07841
STKc_MEKK1 - cd06630
STKc_MAPKKK_Byr2_lik - cd06628
STKc_CDK2_3 - cd07860
STKc_YSK4 - cd06631
STKc_STK10_LOK - cd06644
STKc_CDK5 - cd07839
STKc_Nek11 - cd08222
STKc_Nek4 - cd08223
STKc_Nek10 - cd08528
STKc_Nek9 - cd08221
STKc_Nek8 - cd08220
STKc_CDK4 - cd07863
STKc_CDK1_euk - cd07861
STKc_Nek1 - cd08218
STKc_CDK6 - cd07862
STKc_TDY_MAPK_plant - cd07859
PTKc_Src - cd05071
PTKc_Hck - cd05073
PTKc_DDR2 - cd05095
PTKc_Yes - cd05069
PTKc_Lck_Blk - cd05067
PKc_MAPKK_plant_like - cd06623
PTKc_Ror - cd05048
PTKc_Trk - cd05049
PTKc_DDR_like - cd05097
PTKc_Tie1 - cd05089
PKc_MAPKK - cd06605
PTKc_HER4 - cd05110
PKc_MKK3_6 - cd06617
PKc_MKK5 - cd06619
STKc_PRKX_like - cd05612
PKc_MEK - cd06615
STKc_phototropin_lik - cd05574
STKc_PKA - cd05580
STKc_GRK4_like - cd05605
STKc_MPK1 - cd07857
STKc_NLK - cd07853
STKc_CDK1_like - cd07835
STKc_Nek7 - cd08229
STKc_CDK9_like - cd07840
STKc_Nek6 - cd08228
STKc_Nek6_Nek7 - cd08224
PTKc_RET - cd05045
STKc_CMGC - cd05118
STKc_MAPK - cd07834
STKc_cPKC_alpha - cd05615
PKc_STE - cd05122
PKc_MKK4 - cd06616
STKc_CDK_like - cd07829
STKc_MOK - cd07831
PKc_MEK1 - cd06650
STYKc - smart00221
Pkinase - pfam00069
Pkinase_Tyr - pfam07714
TyrKc - smart00219
PKc_MEK2 - cd06649
PTK_CCK4 - cd05046
STKc_p70S6K - cd05584
PKc_MAPKK_PBS2_like - cd06622
PTKc_Tyro3 - cd05074
STKc_cPKC - cd05587
PTKc_Axl_like - cd05035
STKc_cPKC_beta - cd05616
STKc_PKN - cd05589
STKc_Nek3 - cd08219
PK_STRAD - cd08216
STKc_Nek2 - cd08217
STKc_FA2-like - cd08529
STKc_Nek - cd08215
STKc_CNK2-like - cd08530
STKc_Nek5 - cd08225
STKc_MAPK15 - cd07852
STKc_DMPK_like - cd05597
STKc_PDK1 - cd05581
STKc_Yank1 - cd05578
PTKc_Srm_Brk - cd05148
STKc_CDK12 - cd07864
STKc_MSK1_N - cd05613
STKc_CDK8_like - cd07842
STKc_MRCK_beta - cd05624
STKc_OSR1_SPAK - cd06610
STKc_MAPKKK - cd06606
STKc_myosinIII_like - cd06608
STKc_CDK8 - cd07868
STKc_CDC2L6 - cd07867
STKc_MST1_2 - cd06612
STKc_ERK1_2_like - cd07849
STKc_ERK5 - cd07855
STKc_MAPK4_6 - cd07854
STKc_MAK_like - cd07830
STKc_CRIK - cd05601
PTKc_Tie - cd05047
STKc_CDC2L1 - cd07843
STKc_MEKK4 - cd06626
PTKc_Fes_like - cd05041
PTKc_Ack_like - cd05040
PTKc_Syk_like - cd05060
PTKc_Aatyk - cd05042
PTKc_Zap-70 - cd05115
PTKc_Syk - cd05116
PTKc - cd00192
STKc_SLK_like - cd06611
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Fes - cd05084
STKc_CDK4_6_like - cd07838
PTKc_Aatyk2 - cd05086
STKc_GRK1 - cd05608
STKc_SGK2 - cd05603
STKc_SGK1 - cd05602
STKc_aPKC_zeta - cd05617
STKc_beta_ARK - cd05606
STKc_GRK7 - cd05607
STKc_MEKK1_plant - cd06632
STKc_MAPKKK_Bck1_lik - cd06629
STKc_cGK_PKG - cd05572
STKc_MEKK3_like - cd06625
STKc_PKC - cd05570
STKc_nPKC_theta - cd05619
STKc_GRK3 - cd05633
STKc_aPKC_iota - cd05618
STKc_nPKC_eta - cd05590
STKc_PKB - cd05571
STKc_PKB_beta - cd05595
STKc_GRK - cd05577
STKc_AGC - cd05123
PTKc_Fer - cd05085
PKc - cd00180
PTKc_c-ros - cd05044
PTKc_Met_Ron - cd05058
STKc_MAST_like - cd05579
STKc_SGK - cd05575
STKc_PKB_gamma - cd05593
STKc_RSK_N - cd05582
STKc_nPKC_epsilon - cd05591
STKc_PKB_alpha - cd05594
STKc_aPKC - cd05588
STKc_YPK1_like - cd05585
STKc_Sck1_like - cd05586
STKc_nPKC_theta_delt - cd05592
STKc_GRK5 - cd05632
STKc_GRK6 - cd05630
S_TKc - smart00220
PKc_MAPKK_Pek1_like - cd06621
KIND - smart00750
OSR1_C - pfam12202


Swiss-Prot Protein: Q96J92
Identical to: NP_115763
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
STKc_TAO1cd066356.9e-09149479
STKc_TAO3cd066334.6e-07151479
STKc_PAK1cd066541.1e-09152450
STKc_PAK5cd066584.2e-07152447
STKc_PAKcd066146.1e-20153442
STKc_PAK_Icd066477.9e-18153454
STKc_PAK2cd066556.1e-10153467
STKc_PAK_IIcd066489.6e-13153443
STKc_PAK3cd066565.3e-10153458
STKc_p38alpha_MAPK14cd078774.6e-05153478
STKc_PAK4cd066571.3e-07154449
STKc_PAK6cd066591.2e-09154455
STKc_JNK2cd078760.00021154494
STKc_MAP4K4_6cd066362.2e-06155432
STKc_myosinIIIBcd066395.8e-08155433
STKc_JNK3cd078740.00037155530
PTKc_EGFR_likecd050578.1e-08156441
STKc_p38beta_MAPK11cd078789.5e-05157505
STKc_myosinIIIAcd066386.3e-08158432
STKc_TAOcd066077.7e-09159479
STKc_TAO2cd066349.8e-10159480
STKc_p38cd078513.6e-07159464
STKc_p38gamma_MAPK12cd078801.6e-06159468
STKc_JNKcd078505e-05159492
PKc_MKK7cd066182.2e-08160450
STKc_Sty1_Hog1cd078561.2e-06160463
STKc_CDK9cd078651.9e-07160432
STKc_MSK_Ncd055836.6e-05161451
STKc_MAP4K5cd066461.1e-07163431
STKc_PFTAIRE2cd078702.7e-06164432
PTK_Rykcd050430.00043165401
PTKc_FGFRcd050530.00025165428
PTKc_HER2cd051091.4e-06165441
PTKc_EGFRcd051081.7e-06165495
STKc_ASKcd066241.4e-27165432
STKc_CDK10cd078452.7e-08165435
STKc_BUR1cd078665.7e-07165432
PTK_HER3cd051116.6e-08166445
STKc_TNIKcd066372e-07166432
PTKc_ALK_LTKcd050366e-07167432
PTKc_FAKcd050568.3e-08167436
STKc_SLKcd066432.1e-09167447
STKc_PFTAIRE1cd078690.00047167444
PTKc_InsR_likecd050323.6e-09168429
PTKc_Jak_rpt2cd050385.1e-09168436
STKc_MST3cd066412e-07168453
STKc_STK25-YSK1cd066421.6e-09168450
STKc_MST4cd066405e-08168457
STKc_PCTAIRE_likecd078444e-08168462
STKc_MASTcd056091.3e-05169490
STKc_MAP4K3_likecd066132.2e-15169431
PTKc_EphRcd050333.9e-08170432
PTKc_Src_likecd050341.6e-08170431
PTKc_Muskcd050500.00035170429
PTKc_Ablcd050522.2e-07170431
PTKc_InsRcd050611e-05170440
PTKc_IGF-1Rcd050622.2e-05170432
PTKc_EphR_A2cd050639e-05170431
PTKc_EphR_A10cd050640.00011170431
PTKc_EphR_Bcd050657.4e-06170432
PTKc_EphR_Acd050660.00016170431
PTKc_Frk_likecd050682.1e-12170431
PTKc_Fyn_Yrkcd050702.2e-05170436
PTKc_Lyncd050723.2e-06170430
PTKc_Tec_likecd050599.5e-10170431
PTKc_Jak1_rpt2cd050796.5e-06170432
PTKc_Tyk2_rpt2cd050807.4e-07170435
PTKc_Cskcd050824.1e-05170430
PTKc_Chkcd050831.9e-05170434
PTKc_Tie2cd050880.00012170455
PTKc_TrkAcd050921.9e-05170444
PTKc_TrkBcd050937.8e-05170443
PTKc_TrkCcd050940.001170489
PTKc_Jak2_Jak3_rpt2cd050811.7e-09170434
PTKc_Itkcd051129.7e-09170431
PTKc_Tec_Rlkcd051146.9e-08170431
PTKc_Btk_Bmxcd051132.3e-10170431
PKc_MAPKK_Byr1_likecd066202.9e-07170446
STKc_MEKK3cd066513.3e-13170434
STKc_MAP4K3cd066454.5e-08170431
STKc_TEY_MAPK_plantcd078585e-08170502
STKc_ROCK_NDR_likecd055733.2e-06171479
STKc_MST3_likecd066091.8e-13171450
STKc_MEKK3_like_1cd066535.5e-14171432
STKc_MEKK2cd066522.2e-09171433
STKc_NAK1_likecd069178.2e-13171447
STKc_CDKLcd078332.3e-07171432
STKc_CdkB_plantcd078371.1e-09171433
STKc_CDKL1_4cd078475.4e-09171476
STKc_PCTAIRE2cd078724.3e-06171454
STKc_PCTAIRE3cd078711.8e-07171462
STKc_PCTAIRE1cd078734.4e-05171444
STKc_CDKL2_3cd078464.9e-09171432
SPS1COG05151.6e-45171613
PTKc_Rorcd050483.1e-05172397
PTKc_Trkcd050492.7e-07172429
PTKc_Lck_Blkcd050676.8e-05172447
PTKc_Yescd050695.5e-06172430
PTKc_Srccd050712.5e-05172432
PTKc_Hckcd050736.7e-06172430
PTKc_Tie1cd050892.7e-05172454
PTKc_DDR2cd050954.2e-05172434
PTKc_DDR_likecd050970.001172434
PTKc_HER4cd051103e-05172461
STKc_phototropin_likcd055740.00015172453
STKc_PKAcd055801.5e-09172451
STKc_GRK4_likecd056052.3e-06172453
STKc_PRKX_likecd056125.7e-08172457
PKc_MAPKKcd066053.1e-12172436
PKc_MEKcd066152.5e-10172444
PKc_MKK3_6cd066174.8e-11172451
PKc_MKK5cd066199.7e-07172463
PKc_MAPKK_plant_likecd066239.7e-17172437
STKc_Cdc7_likecd066271.4e-19172432
STKc_MAPKKK_Byr2_likcd066284.3e-21172432
STKc_MEKK1cd066301.1e-11172433
STKc_YSK4cd066315e-15172432
STKc_STK10_LOKcd066441.9e-08172450
STKc_CCRKcd078322.1e-11172433
STKc_Pho85cd078366.9e-09172479
STKc_CDK7cd078411.4e-10172443
STKc_TDY_MAPK_plantcd078593.2e-07172505
STKc_CDK2_3cd078603.1e-06172432
STKc_CDK6cd078620.0005172458
STKc_CDK4cd078631.4e-07172432
STKc_CDK1_eukcd078614.9e-06172432
STKc_CDK5cd078392.6e-08172432
STKc_Nek1cd082186.4e-18172432
STKc_Nek8cd082205.5e-16172432
STKc_Nek9cd082215.8e-10172432
STKc_Nek11cd082225e-17172432
STKc_Nek4cd082237e-21172432
STKc_Nek10cd085281.1e-06172432
PTKc_RETcd050450.001173434
STKc_CMGCcd051182.6e-12173432
PKc_STEcd051221.4e-24173431
STKc_cPKC_alphacd056158.3e-05173489
PKc_MKK4cd066169.4e-10173450
STKc_CDK_likecd078299.7e-18173432
STKc_MAPKcd078343.7e-09173460
STKc_CDK9_likecd078408.3e-10173432
STKc_NLKcd078531.1e-06173520
STKc_MPK1cd078574.4e-06173461
STKc_CDK1_likecd078351.2e-07173457
STKc_Nek6_Nek7cd082243.2e-15173435
STKc_Nek6cd082282.6e-19173435
STKc_Nek7cd082292e-18173435
PTKc_Axl_likecd050351.6e-05174431
PTK_CCK4cd050460.00021174429
PTKc_Tyro3cd050744.5e-05174434
STKc_p70S6Kcd055840.00015174500
STKc_cPKCcd055873.1e-06174489
STKc_PKNcd055892e-05174479
STKc_cPKC_betacd056169.2e-05174489
PKc_MAPKK_PBS2_likecd066222.6e-09174464
PKc_MEK2cd066496.7e-05174455
PKc_MEK1cd066509.1e-05174464
STKc_MOKcd078313.4e-09174432
PTKc_Srm_Brkcd051481.1e-07175431
STKc_Yank1cd055784.3e-13175432
STKc_PDK1cd055811.2e-14175432
STKc_DMPK_likecd055970.00013175504
STKc_MSK1_Ncd056130.00013175451
STKc_MRCK_betacd056240.00066175479
STKc_MAPKKKcd066061.7e-48175432
STKc_myosinIII_likecd066081.2e-11175432
STKc_OSR1_SPAKcd066101.4e-12175432
STKc_CDK8_likecd078421.5e-08175432
STKc_MAPK15cd078524.1e-05175474
STKc_CDK12cd078644.4e-09175432
STKc_Nekcd082151.1e-24175432
PK_STRADcd082169.4e-05175446
STKc_Nek3cd082192e-10175432
STKc_Nek2cd082176.5e-18175432
STKc_Nek5cd082251.9e-15175432
STKc_FA2-likecd085294.5e-16175431
STKc_CNK2-likecd085305.8e-14175432
STKc_CRIKcd056015.8e-06176479
STKc_MST1_2cd066122.4e-14176432
STKc_MAK_likecd078306.5e-12176432
STKc_ERK1_2_likecd078493.8e-06176463
STKc_ERK5cd078556.5e-06176460
STKc_MAPK4_6cd078543.1e-06176461
STKc_CDC2L6cd078671.7e-05176476
STKc_CDK8cd078684.8e-05176476
PTKc_Tiecd050470.00096177435
STKc_MEKK4cd066262.7e-17177432
STKc_CDC2L1cd078432.3e-06177432
PTKccd001926.5e-14178431
PTKc_Fes_likecd050412e-09178429
PTKc_Aatykcd050424.6e-08178429
PTKc_Ack_likecd050401.4e-12178429
PTKc_Syk_likecd050605.4e-08178414
PTKc_Zap-70cd051150.00017178432
PTKc_Sykcd051161.6e-05178433
PTKc_Fescd050841.2e-06179428
PTKc_Aatyk2cd050860.00023179429
PTKc_Aatyk1_Aatyk3cd050870.00023179432
STKc_SLK_likecd066111.4e-10179445
STKc_CDK4_6_likecd078386.1e-10179432
PKccd001801.9e-71180430
PTKc_c-roscd050446.8e-07180429
PTKc_Met_Roncd050580.0003180436
PTKc_Fercd050851e-06180429
STKc_AGCcd051233e-13180432
STKc_PKBcd055711.2e-07180506
STKc_SGKcd055753e-05180498
STKc_GRKcd055774.1e-08180452
STKc_MAST_likecd055792e-08180437
STKc_RSK_Ncd055820.00017180487
STKc_YPK1_likecd055851.3e-06180490
STKc_Sck1_likecd055868.3e-05180571
STKc_aPKCcd055881.2e-06180489
STKc_nPKC_etacd055900.00026180499
STKc_nPKC_epsiloncd055911.1e-05180500
STKc_nPKC_theta_deltcd055921.8e-07180501
STKc_PKB_gammacd055931.6e-05180509
STKc_PKB_alphacd055948.7e-07180501
STKc_PKB_betacd055955.3e-05180506
STKc_cGK_PKGcd055722.2e-10180442
STKc_SGK1cd056024.6e-05180506
STKc_beta_ARKcd056061.8e-07180452
STKc_GRK7cd056073.7e-06180452
STKc_GRK1cd056081.8e-09180452
STKc_SGK2cd056034.5e-06180521
STKc_aPKC_zetacd056173e-06180489
STKc_aPKC_iotacd056187.2e-05180489
STKc_nPKC_thetacd056199.1e-06180494
STKc_GRK3cd056333.9e-06180453
STKc_PKCcd055701.1e-07180479
STKc_MEKK3_likecd066251.3e-23180432
STKc_MAPKKK_Bck1_likcd066291.4e-12180432
STKc_MEKK1_plantcd066321.8e-18180432
STKc_GRK6cd056300.00055184453
STKc_GRK5cd056320.0005184453
PKc_MAPKK_Pek1_likecd066213.4e-07195439
Pkinasepfam000696.5e-58174432
Pkinase_Tyrpfam077143.1e-19174432
TyrKcsmart002191.4e-18174432
STYKcsmart002214.5e-61174432
S_TKcsmart002203.2e-63184432
KINDsmart007506.5e-06260440
OSR1_Cpfam122022.8e-16453489

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs61754326 Polymorphismp.ALA80ASPN/A
dbSNPrs55781437 Polymorphismp.ALA601SERN/A
Swiss-ProtVAR_017591Diseasep.ARG1185CYSPseudohypoaldosteronism 2B (PHA2B)
dbSNPrs9896991 Polymorphismp.ARG677TRPN/A
Swiss-ProtVAR_017589Diseasep.ASP564ALAPseudohypoaldosteronism 2B (PHA2B)
Swiss-ProtVAR_017590Diseasep.GLN565GLUPseudohypoaldosteronism 2B (PHA2B)
Swiss-ProtVAR_041330Polymorphismp.GLU434ASPN/A
Swiss-ProtVAR_017588Diseasep.GLU562LYSPseudohypoaldosteronism 2B (PHA2B)
Swiss-ProtVAR_041333Polymorphismp.LEU1013PRON/A
dbSNPrs57737815 Polymorphismp.PRO555ARGN/A
Swiss-ProtVAR_041331Polymorphismp.PRO813LEUN/A
dbSNPrs56226218 Polymorphismp.PRO825LEUN/A
dbSNPrs2290041 Polymorphismp.PRO961SERN/A
Swiss-ProtVAR_041332Polymorphismp.PRO992SERN/A
OMIM601844.0004 Diseasep.ARG1185CYSPSEUDOHYPOALDOSTERONISM, TYPE IIB
OMIM601844.0003 Diseasep.ASP564ALAPSEUDOHYPOALDOSTERONISM, TYPE IIB
OMIM601844.0001 Diseasep.GLN565GLUPSEUDOHYPOALDOSTERONISM, TYPE IIB
OMIM601844.0002 Diseasep.GLU562LYSPSEUDOHYPOALDOSTERONISM, TYPE IIB



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