Results for the protein: P00519

Results for the Protein: P00519

85681908

25

ABL1

NCBI, UniProt

ABL1_HUMAN RecName: Full=Tyrosine-protein kinase ABL1; AltName: Full=Abelson murine leukemia viral oncogene homolog 1; AltName: Full=Abelson tyrosine-protein kinase 1; AltName: Full=Proto-oncogene c-Abl; AltName: Full=p150

Known Diseases associated with this Protein:
CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB
LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB

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Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

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Swiss-Prot Protein: P00519

Identical to: NP_005148

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	5.1e-33	126	217
PTKc_CSF-1R	cd05106	6.9e-38	200	498
STKc_ROCK	cd05596	0.00084	203	537
PTKc_Kit	cd05104	1.8e-29	204	497
PTKc_PDGFR_beta	cd05107	4.3e-15	204	498
STKc_ROCK2	cd05621	0.0003	207	537
PTKc_PDGFR_alpha	cd05105	1.1e-16	215	499
STKc_TAO1	cd06635	3.6e-06	216	524
STKc_myosinIIIA	cd06638	3e-06	217	495
STKc_PAK6	cd06659	9.1e-05	217	517
STKc_TAO3	cd06633	6.5e-05	219	524
STKc_JNK2	cd07876	0.00069	219	597
STKc_TAO	cd06607	5.7e-06	222	524
STKc_p38alpha_MAPK14	cd07877	1.7e-05	223	580
STKc_JNK3	cd07874	0.00011	223	610
STKc_JNK1	cd07875	0.00064	224	599
STKc_myosinIIIB	cd06639	0.00013	225	494
STKc_p38	cd07851	2.2e-06	225	528
STKc_BUR1	cd07866	4.5e-07	225	493
STKc_p38beta_MAPK11	cd07878	0.00029	225	538
STKc_p38gamma_MAPK12	cd07880	8.2e-05	225	538
PTKc_PDGFR	cd05055	1.2e-30	226	497
PTK_Tyk2_rpt1	cd05076	8.2e-09	226	494
PTKc_FGFR2	cd05101	8.5e-58	226	504
STKc_ERK1_2_like	cd07849	7.4e-06	226	521
PTKc_FGFR1	cd05098	9.3e-58	227	504
STKc_TAO2	cd06634	6.6e-07	227	525
STKc_SLK_like	cd06611	1.4e-09	228	508
STKc_SLK	cd06643	4.9e-07	228	512
PTKc_FGFR	cd05053	1.1e-79	230	498
PTKc_FGFR4	cd05099	1.2e-60	230	520
PTKc_FGFR3	cd05100	2.6e-51	230	546
PKc_MKK7	cd06618	1.2e-10	231	512
STKc_JNK	cd07850	3.4e-05	231	577
STKc_CDK5	cd07839	1.2e-07	231	544
STKc_PCTAIRE1	cd07873	3.8e-06	231	543
STKc_PAK	cd06614	1.5e-12	232	506
STKc_PAK1	cd06654	3.1e-06	232	514
STKc_PCTAIRE3	cd07871	2.2e-07	232	545
STKc_ASK	cd06624	9.1e-09	233	495
STKc_MST4	cd06640	3.8e-08	233	514
STKc_PAK_I	cd06647	7.6e-06	233	512
STKc_MST3	cd06641	2.6e-08	233	514
STKc_PAK2	cd06655	2.8e-06	233	515
STKc_PAK3	cd06656	3.2e-06	233	516
STKc_MAPK15	cd07852	1.2e-06	233	523
STKc_CDK9	cd07865	4.6e-07	233	493
PTKc_VEGFR	cd05054	7.6e-31	234	500
PTKc_EGFR_like	cd05057	4.3e-77	234	503
PTKc_VEGFR2	cd05103	2e-28	234	500
PTKc_VEGFR3	cd05102	5.8e-35	234	500
STKc_PAK_II	cd06648	2.5e-06	234	506
PTKc_InsR_like	cd05032	2.5e-84	235	495
PTKc_Src_like	cd05034	9.7e-140	235	496
PTKc_ALK_LTK	cd05036	8.1e-72	235	495
PTKc_Csk_like	cd05039	1.2e-104	235	496
PTKc_InsR	cd05061	2.5e-64	235	502
PTKc_IGF-1R	cd05062	4.7e-69	235	495
PTKc_Abl	cd05052	1.5e-212	235	497
PTKc_FAK	cd05056	7.4e-95	235	501
PTKc_Lck_Blk	cd05067	1e-101	235	496
PTKc_Frk_like	cd05068	1.7e-125	235	496
PTKc_Yes	cd05069	7.5e-95	235	496
PTKc_Fyn_Yrk	cd05070	1e-97	235	497
PTKc_Src	cd05071	8.8e-94	235	498
PTKc_Lyn	cd05072	5e-102	235	496
PTKc_Hck	cd05073	1.3e-99	235	496
PTKc_Csk	cd05082	5.9e-88	235	496
PTKc_Chk	cd05083	1.1e-86	235	496
PTKc_Tie1	cd05089	4.1e-59	235	516
PTKc_Srm_Brk	cd05148	4.3e-109	235	496
STKc_STK10_LOK	cd06644	7.4e-07	235	515
STKc_TEY_MAPK_plant	cd07858	3.6e-05	235	566
STKc_CDK12	cd07864	4.9e-08	235	515
PTKc_Ror	cd05048	6.2e-62	236	496
PTKc_Trk	cd05049	1.3e-69	236	495
PTKc_EphR_A2	cd05063	1.1e-69	236	497
PTKc_Musk	cd05050	1.5e-79	236	495
PTKc_DDR	cd05051	2.3e-63	236	495
PTK_CCK4	cd05046	4.9e-51	236	495
PTKc_EphR_A10	cd05064	4.7e-58	236	497
PTKc_Ror1	cd05090	3.8e-56	236	496
PTKc_Ror2	cd05091	3e-46	236	496
PTKc_TrkB	cd05093	1.9e-56	236	505
PTKc_TrkC	cd05094	6.2e-41	236	505
PTKc_DDR2	cd05095	5.7e-64	236	495
PTKc_DDR1	cd05096	3.5e-50	236	495
PTKc_DDR_like	cd05097	4.6e-61	236	495
PTKc_TrkA	cd05092	1.1e-57	236	495
PKc_MAPKK_Byr1_like	cd06620	5e-05	236	511
STKc_MAP4K4_6	cd06636	0.00012	236	494
STKc_TNIK	cd06637	2.4e-06	236	494
STKc_STK25-YSK1	cd06642	2.9e-09	236	514
STKc_MAP4K3	cd06645	3e-07	236	493
STKc_MAP4K5	cd06646	2.9e-06	236	492
PKc_MEK1	cd06650	0.00014	236	555
PKc_MEK2	cd06649	2.5e-05	236	530
STKc_PCTAIRE2	cd07872	1.1e-06	236	531
STKc_Nek8	cd08220	1.2e-05	236	494
PTKc_EphR	cd05033	4.8e-89	237	497
PTKc_Jak_rpt2	cd05038	7.5e-72	237	497
PTK_Ryk	cd05043	9.1e-39	237	496
PTKc_Tec_like	cd05059	1.5e-111	237	494
PTKc_EphR_B	cd05065	1e-70	237	497
PTKc_EphR_A	cd05066	1.7e-70	237	497
PTKc_Jak1_rpt2	cd05079	3.4e-47	237	497
PTKc_Tyk2_rpt2	cd05080	5.6e-36	237	498
PTKc_Jak2_Jak3_rpt2	cd05081	2.6e-52	237	497
PTKc_EGFR	cd05108	6.1e-59	237	551
PTKc_HER2	cd05109	4.8e-61	237	507
PTK_HER3	cd05111	4.6e-45	237	507
PTKc_Itk	cd05112	2.5e-93	237	494
PTKc_Btk_Bmx	cd05113	4.6e-101	237	494
PTKc_Tec_Rlk	cd05114	4.8e-95	237	494
PTKc_HER4	cd05110	5e-51	237	527
PTKc_Tie2	cd05088	1.3e-55	237	517
PKc_MKK4	cd06616	3e-10	237	510
STKc_PCTAIRE_like	cd07844	2.7e-08	237	528
STKc_CDK10	cd07845	8.4e-07	237	508
STKc_PFTAIRE1	cd07869	0.00022	237	552
STKc_MAP4K3_like	cd06613	9.2e-12	238	493
STKc_PFTAIRE2	cd07870	6e-07	238	527
STKc_MEKK3_like_1	cd06653	7.6e-06	239	495
STKc_Nek6_Nek7	cd08224	2.2e-10	239	498
STKc_phototropin_lik	cd05574	2.1e-05	240	504
STKc_PKA	cd05580	8.3e-08	240	547
STKc_PDK1	cd05581	8.6e-12	240	493
STKc_CRIK	cd05601	0.00014	240	529
STKc_PRKX_like	cd05612	3.7e-07	240	523
STKc_MAST	cd05609	5e-05	240	560
PKc_MAPKK	cd06605	3.7e-12	240	499
STKc_myosinIII_like	cd06608	5e-07	240	494
STKc_MST3_like	cd06609	4e-12	240	513
STKc_OSR1_SPAK	cd06610	1.5e-11	240	493
STKc_MST1_2	cd06612	1.3e-10	240	489
PKc_MEK	cd06615	6.5e-08	240	510
PKc_MKK5	cd06619	1.2e-05	240	514
PKc_MAPKK_Pek1_like	cd06621	3e-07	240	476
STKc_MEKK3_like	cd06625	5.6e-10	240	495
PKc_MKK3_6	cd06617	9e-11	240	511
PKc_MAPKK_PBS2_like	cd06622	2.6e-08	240	554
PKc_MAPKK_plant_like	cd06623	5.6e-13	240	499
STKc_CDKL1_4	cd07847	3.4e-09	240	528
STKc_MAPK4_6	cd07854	0.00031	240	561
STKc_CDK6	cd07862	7.3e-05	240	539
STKc_Nek7	cd08229	6.4e-12	240	498
STKc_Nek6	cd08228	8.2e-15	240	498
SPS1	COG0515	9e-35	240	657
PTKc_RET	cd05045	3.3e-67	241	500
PKc_STE	cd05122	5.8e-15	241	493
STKc_MSK_N	cd05583	5.1e-06	241	517
STKc_cPKC	cd05587	5.4e-07	241	566
STKc_MSK1_N	cd05613	0.00035	241	512
STKc_MSK2_N	cd05614	0.00023	241	570
STKc_cPKC_alpha	cd05615	2.8e-06	241	554
STKc_cPKC_beta	cd05616	2.1e-05	241	554
STKc_MEKK3	cd06651	3.1e-06	241	496
STKc_Cdc7_like	cd06627	2.2e-15	241	493
STKc_MAPKKK	cd06606	8.6e-20	241	487
STKc_CCRK	cd07832	1e-08	241	487
STKc_Pho85	cd07836	1.8e-06	241	544
STKc_MAPK	cd07834	1.1e-08	241	522
STKc_CdkB_plant	cd07837	5.3e-07	241	499
STKc_Sty1_Hog1	cd07856	6.3e-05	241	514
STKc_MPK1	cd07857	5.2e-05	241	510
STKc_TDY_MAPK_plant	cd07859	2.6e-05	241	566
STKc_CDK2_3	cd07860	1.1e-06	241	493
STKc_CDK1_euk	cd07861	1.5e-10	241	544
STKc_CDK4	cd07863	0.00015	241	493
STKc_Nek	cd08215	1.4e-15	241	502
STKc_Nek1	cd08218	1.6e-06	241	495
STKc_Nek2	cd08217	2.8e-10	241	495
STKc_Nek11	cd08222	3.4e-13	241	495
STKc_Nek4	cd08223	4.7e-09	241	494
STKc_Nek5	cd08225	2.6e-06	241	494
STKc_Nek3	cd08219	1.3e-10	241	495
STKc_FA2-like	cd08529	1.8e-09	241	502
STKc_CNK2-like	cd08530	1.6e-07	241	493
STKc_Nek10	cd08528	1.2e-07	241	495
PTKc_Axl_like	cd05035	5.8e-84	242	497
PTKc_Tyro3	cd05074	1.6e-76	242	497
PTKc_Axl	cd05075	7.1e-71	242	497
STKc_PKN	cd05589	1.2e-07	242	565
STKc_CDK1_like	cd07835	1.1e-07	242	544
STKc_GRK4_like	cd05605	6.9e-06	243	531
STKc_NAK1_like	cd06917	1.9e-11	243	510
STKc_CDK_like	cd07829	9.3e-14	243	493
STKc_MAK_like	cd07830	5.5e-13	243	495
STKc_CDK7	cd07841	1.3e-09	243	506
PK_STRAD	cd08216	3.8e-05	243	512
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-11	244	494
STKc_MAPKKK_Bck1_lik	cd06629	6.4e-09	244	487
STKc_YSK4	cd06631	1.1e-09	244	493
STKc_CDKL2_3	cd07846	4.7e-09	244	493
STKc_RSK_N	cd05582	1.5e-06	245	561
STKc_p70S6K	cd05584	1.4e-05	245	561
STKc_MEKK4	cd06626	3.4e-10	245	494
STKc_CDK9_like	cd07840	5e-10	245	486
PTKc	cd00192	2e-144	246	494
PTK_Jak_rpt1	cd05037	1.9e-12	246	494
PTKc_Ack_like	cd05040	1.3e-83	246	495
PTKc_Fes_like	cd05041	8.5e-98	246	495
PTKc_Aatyk	cd05042	1.5e-19	246	495
PTKc_c-ros	cd05044	1.1e-71	246	495
PTKc_Tie	cd05047	2.1e-64	246	498
PTKc_Syk_like	cd05060	1.1e-96	246	498
PTKc_Met_Ron	cd05058	1.6e-70	246	499
PTK_Jak1_rpt1	cd05077	7.6e-11	246	494
PTK_Jak2_Jak3_rpt1	cd05078	2.2e-12	246	494
PTKc_Fes	cd05084	4.7e-79	246	495
PTKc_Fer	cd05085	7.6e-89	246	495
PTKc_Aatyk2	cd05086	2.8e-22	246	495
PTKc_Aatyk1_Aatyk3	cd05087	3.2e-35	246	495
PTKc_Syk	cd05116	1.2e-71	246	498
STKc_CMGC	cd05118	6.3e-12	246	493
STKc_PKC	cd05570	1e-09	246	550
STKc_PKB	cd05571	1.7e-08	246	567
STKc_SGK	cd05575	8.3e-06	246	547
STKc_aPKC	cd05588	6.8e-07	246	566
STKc_nPKC_epsilon	cd05591	2e-06	246	566
STKc_nPKC_theta_delt	cd05592	8.1e-08	246	561
STKc_PKB_gamma	cd05593	8.7e-06	246	576
STKc_PKB_alpha	cd05594	1.6e-07	246	562
STKc_PKB_beta	cd05595	9.1e-06	246	567
STKc_nPKC_eta	cd05590	6.4e-06	246	548
STKc_SGK2	cd05603	2.3e-07	246	562
STKc_SGK3	cd05604	0.00087	246	561
STKc_SGK1	cd05602	0.00032	246	561
STKc_aPKC_zeta	cd05617	2e-05	246	566
STKc_aPKC_iota	cd05618	8.7e-05	246	562
STKc_nPKC_theta	cd05619	4.7e-08	246	552
STKc_nPKC_delta	cd05620	0.00023	246	561
STKc_MEKK1	cd06630	1.6e-08	246	494
STKc_MOK	cd07831	7.9e-07	246	493
STKc_CDKL	cd07833	4.4e-09	246	493
PTKc_Zap-70	cd05115	4.6e-66	247	498
STKc_CDK4_6_like	cd07838	2.8e-06	247	493
STKc_CDK8_like	cd07842	6.4e-06	247	493
STKc_CDC2L6	cd07867	0.00044	247	544
PKc	cd00180	2.2e-68	248	493
STKc_AGC	cd05123	1e-11	248	493
STKc_cGK_PKG	cd05572	2.2e-09	248	500
STKc_ROCK_NDR_like	cd05573	0.00014	248	536
STKc_MAST_like	cd05579	2.2e-07	248	491
STKc_YPK1_like	cd05585	2.7e-06	248	560
STKc_Sck1_like	cd05586	1.3e-05	248	612
STKc_GRK7	cd05607	0.00048	248	518
STKc_GRK1	cd05608	0.00025	248	530
STKc_MEKK1_plant	cd06632	3.3e-11	248	489
STKc_Nek9	cd08221	2.3e-08	248	495
STKc_Yank1	cd05578	3.1e-08	249	496
STKc_CDC2L1	cd07843	0.0001	251	493
SH3_1	pfam00018	5.1e-16	67	113
SH2	pfam00017	6.8e-34	127	202
Pkinase	pfam00069	2.3e-47	242	493
SH3	smart00326	4.8e-17	62	119
SH3_2	pfam07653	1.1e-06	65	118
SH2	smart00252	1.6e-32	125	208
Pkinase_Tyr	pfam07714	2.7e-155	242	493
TyrKc	smart00219	5.3e-149	242	493
STYKc	smart00221	2e-66	242	495
S_TKc	smart00220	6e-62	252	497
KIND	smart00750	4.1e-05	321	503
F_actin_bind	pfam08919	1.3e-140	953	1130
FABD	smart00808	6.5e-70	1006	1130

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_032676	Polymorphism	p.ARG47GLY	N/A
Swiss-Prot	VAR_032677	Polymorphism	p.ARG166LYS	N/A
Swiss-Prot	VAR_025043	Polymorphism	p.GLY706VAL	N/A
Swiss-Prot	VAR_051692	Polymorphism	p.LEU140PRO	N/A
Swiss-Prot	VAR_051693	Polymorphism	p.LYS247ARG	N/A
Swiss-Prot	VAR_032678	Polymorphism	p.PRO810LEU	N/A
Swiss-Prot	VAR_025045	Polymorphism	p.PRO900SER	N/A
dbSNP	rs2229067	Polymorphism	p.SER972LEU	N/A
Swiss-Prot	VAR_051694	Polymorphism	p.SER968PRO	N/A
Swiss-Prot	VAR_025044	Polymorphism	p.THR852PRO	N/A
OMIM	189980.0003	Disease	p.GLU236LYS	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
OMIM	189980.0002	Disease	p.GLU236VAL	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
OMIM	189980.0006	Disease	p.MET332THR	CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB
OMIM	189980.0005	Disease	p.PHE292LEU	CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB
OMIM	189980.0001	Disease	p.THR296ILE	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
OMIM	189980.0004	Disease	p.TYR234HIS	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258