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Results for the Protein: Q9Y2U5
97536681

M3K2_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase 2; AltName: Full=MAPK/ERK kinase kinase 2; Short=MEK kinase 2; Short=MEKK 2
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

PB1 - pfam00564
PB1 - smart00666
PB1_Mekk2_3 - cd06405
PB1 - cd05992
STKc_ROCK - cd05596
STKc_ROCK2 - cd05621
STKc_ROCK1 - cd05622
STKc_TAO1 - cd06635
STKc_JNK1 - cd07875
STKc_TAO3 - cd06633
STKc_PAK5 - cd06658
STKc_PAK1 - cd06654
STKc_PAK2 - cd06655
STKc_PAK_I - cd06647
STKc_PAK4 - cd06657
STKc_myosinIIIB - cd06639
STKc_PAK - cd06614
STKc_myosinIIIA - cd06638
STKc_PAK3 - cd06656
STKc_CDK9 - cd07865
STKc_PAK_II - cd06648
PKc_MKK7 - cd06618
STKc_MAP4K4_6 - cd06636
STKc_p38 - cd07851
STKc_PAK6 - cd06659
STKc_TAO2 - cd06634
STKc_Sty1_Hog1 - cd07856
STKc_JNK - cd07850
STKc_BUR1 - cd07866
PTKc_FGFR - cd05053
PTKc_FGFR2 - cd05101
PTKc_FGFR4 - cd05099
STKc_MAP4K3 - cd06645
STKc_MAP4K5 - cd06646
STKc_STK10_LOK - cd06644
STKc_ASK - cd06624
PTKc_EGFR_like - cd05057
PTK_HER3 - cd05111
PTKc_Hck - cd05073
PTKc_DDR_like - cd05097
PTKc_DDR2 - cd05095
PTKc_InsR - cd05061
PTKc_Src - cd05071
PTKc_DDR - cd05051
PTKc_Yes - cd05069
PTKc_Musk - cd05050
STKc_myosinIII_like - cd06608
STKc_CDK12 - cd07864
STKc_MAPK15 - cd07852
STKc_TNIK - cd06637
STKc_CDK10 - cd07845
PTK_CCK4 - cd05046
PTKc_Lck_Blk - cd05067
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE3 - cd07871
STKc_PCTAIRE1 - cd07873
STKc_PFTAIRE1 - cd07869
STKc_SLK - cd06643
PTKc_Ror - cd05048
STKc_PCTAIRE_like - cd07844
STKc_ERK5 - cd07855
STKc_TEY_MAPK_plant - cd07858
PTKc_Btk_Bmx - cd05113
PTKc_Tec_Rlk - cd05114
PTKc_Itk - cd05112
PTKc_HER2 - cd05109
STKc_MST1_2 - cd06612
PTKc_HER4 - cd05110
STKc_MST4 - cd06640
STKc_PFTAIRE2 - cd07870
STKc_STK25-YSK1 - cd06642
PTKc_EGFR - cd05108
PKc_MAPKK_Byr1_like - cd06620
STKc_MAP4K3_like - cd06613
STKc_MST3 - cd06641
PTKc_FAK - cd05056
PTKc_InsR_like - cd05032
PTKc_Abl - cd05052
PTKc_ALK_LTK - cd05036
PTKc_TrkA - cd05092
PTK_Ryk - cd05043
PTKc_IGF-1R - cd05062
PTKc_EphR_A10 - cd05064
PTKc_Csk - cd05082
PTKc_EphR_A2 - cd05063
PTKc_Lyn - cd05072
PTKc_Fyn_Yrk - cd05070
PTKc_EphR_B - cd05065
PTKc_EphR_A - cd05066
PTKc_Frk_like - cd05068
PK_STRAD - cd08216
STKc_MEKK3_like_1 - cd06653
STKc_ERK1_2_like - cd07849
STKc_MEKK2 - cd06652
PTKc_EphR - cd05033
PTKc_Tec_like - cd05059
STKc_MEKK3 - cd06651
STKc_MEKK3_like - cd06625
PKc_MAPKK_plant_like - cd06623
STKc_MAPKKK_Bck1_lik - cd06629
PKc_MKK5 - cd06619
STKc_SLK_like - cd06611
STKc_OSR1_SPAK - cd06610
PKc_MEK1 - cd06650
PKc_MEK - cd06615
PKc_MKK3_6 - cd06617
STKc_CDKL5 - cd07848
STKc_Nek7 - cd08229
SPS1 - COG0515
STKc_Nek6 - cd08228
STKc_Nek6_Nek7 - cd08224
STKc_CdkB_plant - cd07837
STKc_MST3_like - cd06609
STKc_NAK1_like - cd06917
STKc_CDK6 - cd07862
PTKc_TrkC - cd05094
STKc_ROCK_NDR_like - cd05573
STKc_phototropin_lik - cd05574
PTKc_TrkB - cd05093
PTKc_Ror1 - cd05090
PTKc_Jak1_rpt2 - cd05079
STKc_NDR1 - cd05628
PTKc_Chk - cd05083
STKc_PKA - cd05580
PTKc_Trk - cd05049
STKc_PDK1 - cd05581
STKc_MRCK_beta - cd05624
STKc_LATS1 - cd05625
STKc_PRKX_like - cd05612
STKc_MRCK_alpha - cd05623
STKc_MAST - cd05609
STKc_LATS - cd05598
STKc_DMPK_like - cd05597
STKc_CRIK - cd05601
STKc_CDK1_euk - cd07861
STKc_CDK4 - cd07863
STKc_MPK1 - cd07857
STKc_Nek - cd08215
STKc_Pho85 - cd07836
STKc_Nek1 - cd08218
STKc_CDK7 - cd07841
STKc_NLK - cd07853
STKc_TDY_MAPK_plant - cd07859
STKc_CDK2_3 - cd07860
STKc_Nek5 - cd08225
STKc_CNK2-like - cd08530
STKc_Nek10 - cd08528
STKc_MAPK - cd07834
STKc_FA2-like - cd08529
STKc_Nek4 - cd08223
STKc_Nek9 - cd08221
STKc_Nek11 - cd08222
STKc_Nek8 - cd08220
STKc_Nek3 - cd08219
STKc_Cdc7_like - cd06627
STKc_MSK1_N - cd05613
STKc_MSK2_N - cd05614
STKc_CCRK - cd07832
STKc_cPKC_beta - cd05616
STKc_GRK4_like - cd05605
STKc_cPKC - cd05587
PTKc_RET - cd05045
PKc_STE - cd05122
STKc_Yank1 - cd05578
STKc_MSK_N - cd05583
STKc_GRK6 - cd05630
STKc_cPKC_alpha - cd05615
STKc_MAPKKK_Byr2_lik - cd06628
STKc_GRK4 - cd05631
STKc_YSK4 - cd06631
STKc_MEKK1_plant - cd06632
STKc_MEKK1 - cd06630
STKc_GRK5 - cd05632
STKc_MEKK4 - cd06626
STKc_MAPKKK - cd06606
STKc_TAO - cd06607
STKc_MAPK4_6 - cd07854
STKc_CDK4_6_like - cd07838
STYKc - smart00221
STKc_MOK - cd07831
TyrKc - smart00219
Pkinase_Tyr - pfam07714
Pkinase - pfam00069
STKc_CDK1_like - cd07835
PTKc_Axl - cd05075
PTKc_Srm_Brk - cd05148
STKc_MAK_like - cd07830
PTKc_Axl_like - cd05035
PTKc_Tyro3 - cd05074
PTKc_Csk_like - cd05039
STKc_CDK_like - cd07829
STKc_PKN - cd05589
PTKc_Src_like - cd05034
STKc_CDK9_like - cd07840
STKc_CDKL1_4 - cd07847
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Tyk2_rpt2 - cd05080
PTKc_Jak_rpt2 - cd05038
STKc_CMGC - cd05118
STKc_CDK5 - cd07839
STKc_CDKL2_3 - cd07846
STKc_CDK8_like - cd07842
PKc_MAPKK_PBS2_like - cd06622
STKc_CDK8 - cd07868
PKc_MAPKK_Pek1_like - cd06621
STKc_CDKL - cd07833
STKc_p70S6K - cd05584
STKc_CDC2L6 - cd07867
STKc_SGK2 - cd05603
STKc_SGK1 - cd05602
STKc_PKB_gamma - cd05593
STKc_NDR_like - cd05599
STKc_PKB_beta - cd05595
STKc_nPKC_eta - cd05590
PKc_MAPKK - cd06605
STKc_Nek2 - cd08217
STKc_nPKC_theta - cd05619
STKc_nPKC_theta_delt - cd05592
STKc_PKB_alpha - cd05594
STKc_Rim15_like - cd05611
STKc_nPKC_epsilon - cd05591
STKc_aPKC - cd05588
PTK_Jak_rpt1 - cd05037
PTKc - cd00192
PTKc_Ack_like - cd05040
PTKc_Fes_like - cd05041
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Syk_like - cd05060
PTKc_Met_Ron - cd05058
STKc_PKC - cd05570
PTKc_Syk - cd05116
STKc_PKB - cd05571
STKc_SGK - cd05575
STKc_RSK_N - cd05582
PTKc_Fes - cd05084
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Fer - cd05085
STKc_beta_ARK - cd05606
STKc_GRK3 - cd05633
PKc_MKK4 - cd06616
PKc_MEK2 - cd06649
STKc_GRK1 - cd05608
STKc_AGC - cd05123
STKc_cGK_PKG - cd05572
PTKc_Zap-70 - cd05115
PKc - cd00180
STKc_GRK7 - cd05607
STKc_GRK - cd05577
STKc_MAST_like - cd05579
STKc_YPK1_like - cd05585
STKc_Sid2p_Dbf2p - cd05600
STKc_CDC2L1 - cd07843
S_TKc - smart00220
KIND - smart00750


Swiss-Prot Protein: Q9Y2U5
Identical to: NP_006600
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
PB1_Mekk2_3cd064051.5e-5544122
STKc_ROCKcd055967.9e-06312619
STKc_ROCK2cd056212.1e-05312619
STKc_ROCK1cd056220.00011314619
STKc_TAO1cd066355.3e-11324619
STKc_JNK1cd078750.00068324619
STKc_TAO3cd066334e-08328619
STKc_PAK1cd066541.4e-19329619
STKc_PAK5cd066588.7e-13329619
STKc_PAK_Icd066473.1e-29330619
STKc_PAK2cd066551.2e-20330619
STKc_PAK4cd066572.5e-08331619
STKc_myosinIIIBcd066391.1e-17332617
STKc_PAKcd066145.7e-32333618
STKc_myosinIIIAcd066385.9e-23333616
STKc_PAK_IIcd066484.7e-15334617
STKc_PAK3cd066563.6e-18334619
STKc_CDK9cd078657.5e-09334616
PKc_MKK7cd066181.5e-11337619
STKc_MAP4K4_6cd066363.1e-29337616
STKc_PAK6cd066592.1e-11338618
STKc_p38cd078511.1e-07338619
STKc_TAO2cd066344.6e-11339619
STKc_JNKcd078500.00062339619
STKc_Sty1_Hog1cd078562.2e-07339619
STKc_BUR1cd078664.3e-13340616
PTKc_FGFRcd050530.00022341594
PTKc_FGFR2cd051010.00028341618
PTKc_FGFR4cd050990.00011341619
STKc_MAP4K3cd066456.5e-38342615
STKc_MAP4K5cd066467.2e-37342615
PTKc_EGFR_likecd050573.5e-06347619
PTK_HER3cd051119.2e-07347617
STKc_ASKcd066241e-65347616
STKc_STK10_LOKcd066448.4e-27347618
PTKc_Muskcd050500.00023348616
PTKc_InsRcd050612e-05348603
PTKc_DDRcd050511.2e-05348596
PTKc_Yescd050691.4e-06348618
PTKc_Srccd050719.8e-07348619
PTKc_Hckcd050737.2e-07348618
PTKc_DDR2cd050953.1e-05348616
PTKc_DDR_likecd050970.00019348616
STKc_myosinIII_likecd066083.3e-24349616
STKc_CDK12cd078646e-12349616
PTK_CCK4cd050462e-05350616
PTKc_Lck_Blkcd050671.6e-06350618
STKc_TNIKcd066373.1e-26350616
STKc_CDK10cd078456.9e-11350619
STKc_MAPK15cd078529.5e-09350618
PTKc_Rorcd050482.4e-05351580
STKc_SLKcd066432.1e-22351618
STKc_PCTAIRE_likecd078442.6e-08351616
STKc_ERK5cd078554.1e-07351619
STKc_TEY_MAPK_plantcd078583.3e-05351619
STKc_PFTAIRE1cd078690.00034351617
STKc_PCTAIRE3cd078712.5e-08351616
STKc_PCTAIRE2cd078721.7e-05351619
STKc_PCTAIRE1cd078731.3e-06351619
PTKc_InsR_likecd050322.8e-08352616
PTKc_ALK_LTKcd050363.7e-09352595
PTK_Rykcd050434.3e-06352597
PTKc_Ablcd050522.5e-06352615
PTKc_FAKcd050562.2e-08352619
PTKc_IGF-1Rcd050624.9e-06352616
PTKc_EphR_A10cd050643.4e-05352615
PTKc_EphR_Bcd050650.00013352615
PTKc_EphR_Acd050660.0005352615
PTKc_Frk_likecd050681.5e-08352618
PTKc_Fyn_Yrkcd050702.4e-05352618
PTKc_Lyncd050728.3e-08352618
PTKc_Cskcd050823.1e-06352618
PTKc_EphR_A2cd050631.5e-05352615
PTKc_TrkAcd050927.2e-08352617
PTKc_EGFRcd051080.00059352613
PTKc_HER2cd051099e-06352619
PTKc_HER4cd051100.0006352619
PTKc_Itkcd051122.1e-10352615
PTKc_Btk_Bmxcd051131.4e-09352615
PTKc_Tec_Rlkcd051142.8e-09352615
STKc_MST1_2cd066121.5e-49352616
STKc_MAP4K3_likecd066138.9e-45352615
PKc_MAPKK_Byr1_likecd066201.3e-12352619
STKc_MST4cd066404.8e-26352619
STKc_MST3cd066416.2e-26352619
STKc_STK25-YSK1cd066421.1e-27352619
STKc_PFTAIRE2cd078702.7e-07352616
PTKc_EphRcd050339.8e-05353597
PTKc_Tec_likecd050593.1e-09353615
STKc_MEKK3_likecd066251.6e-219353616
STKc_MEKK3cd066519.3e-221353618
STKc_MEKK2cd066525.6e-237353617
STKc_MEKK3_like_1cd066535.6e-210353616
STKc_ERK1_2_likecd078493.3e-08353619
PK_STRADcd082167e-09353618
PTKc_Trkcd050491.8e-09354613
PTKc_Jak1_rpt2cd050795.6e-17354619
PTKc_Chkcd050832.4e-05354617
PTKc_Ror1cd050900.00024354614
PTKc_TrkBcd050932.3e-07354609
PTKc_TrkCcd050946.1e-05354609
STKc_ROCK_NDR_likecd055735.1e-12354619
STKc_phototropin_likcd055745.3e-08354615
STKc_PKAcd055803.6e-13354618
STKc_PDK1cd055812.5e-18354616
STKc_DMPK_likecd055970.00042354619
STKc_LATScd055987.4e-06354615
STKc_CRIKcd056018.7e-09354616
STKc_MASTcd056096.2e-08354619
STKc_PRKX_likecd056122.9e-10354619
STKc_MRCK_alphacd056230.00029354619
STKc_MRCK_betacd056240.00019354619
STKc_LATS1cd056250.00035354615
STKc_NDR1cd056280.0001354619
STKc_MST3_likecd066093.9e-48354619
STKc_OSR1_SPAKcd066102.1e-22354616
STKc_SLK_likecd066112.1e-17354619
PKc_MEKcd066154.1e-12354619
PKc_MKK3_6cd066172.8e-12354619
PKc_MKK5cd066194.4e-07354619
PKc_MAPKK_plant_likecd066232.4e-37354618
STKc_MAPKKK_Bck1_likcd066292.3e-60354616
PKc_MEK1cd066500.00012354616
STKc_NAK1_likecd069172.4e-24354619
STKc_CdkB_plantcd078374.1e-12354617
STKc_CDKL5cd078480.00022354616
STKc_CDK6cd078625e-06354616
STKc_Nek6_Nek7cd082241.6e-17354616
STKc_Nek6cd082284.6e-17354616
STKc_Nek7cd082292e-17354616
SPS1COG05154.1e-35354619
PTKc_RETcd050450.00014355618
PKc_STEcd051225.6e-70355615
STKc_Yank1cd055783.9e-12355616
STKc_MSK_Ncd055838.5e-09355617
STKc_cPKCcd055871.6e-05355617
STKc_GRK4_likecd056051e-06355619
STKc_MSK1_Ncd056133e-07355618
STKc_MSK2_Ncd056145.8e-06355618
STKc_cPKC_alphacd056151.4e-05355617
STKc_cPKC_betacd056163e-05355619
STKc_GRK6cd056305.7e-05355619
STKc_GRK4cd056313.3e-05355619
STKc_GRK5cd056322.6e-05355619
STKc_MAPKKKcd066066.7e-142355616
STKc_TAOcd066073e-11355619
STKc_MEKK4cd066262.9e-69355616
STKc_Cdc7_likecd066274.3e-77355616
STKc_MAPKKK_Byr2_likcd066283.5e-94355616
STKc_YSK4cd066316.5e-99355616
STKc_MEKK1_plantcd066321.5e-113355616
STKc_MEKK1cd066306.1e-73355616
STKc_CCRKcd078322e-15355617
STKc_MAPKcd078342.8e-11355619
STKc_Pho85cd078362.4e-16355616
STKc_CDK7cd078411.9e-15355616
STKc_NLKcd078530.00011355619
STKc_TDY_MAPK_plantcd078597.1e-05355619
STKc_CDK2_3cd078602.7e-12355616
STKc_CDK1_eukcd078613.9e-10355616
STKc_CDK4cd078631.6e-09355616
STKc_MPK1cd078571.4e-06355618
STKc_Nekcd082151.5e-45355616
STKc_Nek1cd082181.7e-25355616
STKc_Nek3cd082192.4e-25355616
STKc_Nek9cd082212.3e-17355616
STKc_Nek11cd082222.9e-31355616
STKc_Nek8cd082207e-28355616
STKc_Nek5cd082254.4e-30355616
STKc_Nek4cd082232.1e-22355616
STKc_FA2-likecd085298.2e-17355616
STKc_CNK2-likecd085302.9e-14355616
STKc_Nek10cd085281.4e-09355616
PTKc_Src_likecd050346.4e-10356618
PTKc_Axl_likecd050354.4e-06356618
PTKc_Csk_likecd050395.9e-06356573
PTKc_Tyro3cd050741.9e-06356618
PTKc_Axlcd050750.00012356618
PTKc_Srm_Brkcd051483.5e-07356618
STKc_PKNcd055891.7e-06356618
STKc_CDK_likecd078294.6e-19356616
STKc_MAK_likecd078307.3e-14356616
STKc_MOKcd078314e-14356616
STKc_CDK1_likecd078357.6e-11356619
STKc_CDK4_6_likecd078387.6e-13356616
STKc_MAPK4_6cd078544.3e-07356619
PTKc_Jak_rpt2cd050388.4e-13357617
PTKc_Tyk2_rpt2cd050801.6e-11357619
PTKc_Jak2_Jak3_rpt2cd050817.3e-11357618
STKc_CMGCcd051181.3e-17357616
STKc_CDK5cd078394.2e-10357616
STKc_CDKL2_3cd078461.5e-12357616
STKc_CDKL1_4cd078471.1e-11357616
STKc_CDK9_likecd078402.5e-17357616
PKc_MAPKK_PBS2_likecd066221e-09358619
STKc_CDK8_likecd078425.2e-12358616
STKc_p70S6Kcd055843.4e-05359619
PKc_MAPKK_Pek1_likecd066213.9e-16359619
STKc_CDKLcd078339.3e-13359616
STKc_CDC2L6cd078673.9e-05359616
STKc_CDK8cd078686.6e-05359619
PTKccd001921.1e-17360615
PTK_Jak_rpt1cd050370.001360615
PTKc_Ack_likecd050404.1e-10360595
PTKc_Fes_likecd050414.7e-10360616
PTKc_Aatykcd050426.9e-05360613
PTKc_c-roscd050441.4e-05360613
PTKc_Met_Roncd050583.1e-05360619
PTKc_Syk_likecd050602e-06360599
PTKc_Fescd050846.5e-06360616
PTKc_Fercd050851.7e-06360616
PTKc_Aatyk1_Aatyk3cd050876.4e-05360618
PTKc_Sykcd051166.7e-05360619
STKc_PKCcd055705e-10360616
STKc_PKBcd055714.1e-07360619
STKc_SGKcd055757.3e-05360619
STKc_RSK_Ncd055820.00053360616
STKc_aPKCcd055880.00054360617
STKc_nPKC_epsiloncd055911.6e-05360619
STKc_nPKC_theta_deltcd055927e-06360618
STKc_PKB_gammacd055931.1e-05360619
STKc_PKB_betacd055953.5e-05360619
STKc_SGK1cd056020.0001360618
STKc_SGK2cd056032.3e-05360617
STKc_NDR_likecd055996.9e-07360619
STKc_Rim15_likecd056114.1e-06360619
STKc_PKB_alphacd055947.1e-06360619
STKc_nPKC_etacd055900.0001360617
STKc_nPKC_thetacd056192.2e-06360619
PKc_MAPKKcd066055.4e-19360618
STKc_Nek2cd082171e-19360616
STKc_beta_ARKcd056061.3e-07361618
STKc_GRK3cd056331e-05361619
PKc_MKK4cd066166.7e-11361619
PKccd001802e-77362614
PTKc_Zap-70cd051154.8e-05362619
STKc_AGCcd051232.2e-16362616
STKc_cGK_PKGcd055724.8e-14362617
STKc_GRKcd055773.8e-09362615
STKc_MAST_likecd055796.5e-18362618
STKc_YPK1_likecd055854.6e-05362619
STKc_Sid2p_Dbf2pcd056003.7e-07362619
STKc_GRK7cd056075.6e-06362619
STKc_GRK1cd056086.4e-08362618
PKc_MEK2cd066494.4e-05362619
STKc_CDC2L1cd078432e-09365616
PB1pfam005646.1e-1943122
Pkinasepfam000691.5e-79356616
PB1smart006662.6e-1943120
Pkinase_Tyrpfam077144.7e-19356614
TyrKcsmart002199.9e-17356614
STYKcsmart002211.7e-84356616
S_TKcsmart002205.1e-91366616
KINDsmart007505.9e-08443616

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_040684Polymorphismp.ASP140GLYN/A
Swiss-ProtVAR_040682Polymorphismp.ILE110VALN/A
Swiss-ProtVAR_040683Polymorphismp.MET112ILEN/A



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