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  Domain Name: Ferric_reduct
Ferric reductase like transmembrane component. This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
No pairwise interactions found for the domain Ferric_reduct

Total Mutations Found: 15
Total Disease Mutations Found: 6
This domain occurred 11 times on human genes (22 proteins).



  ATYPICAL MYCOBACTERIOSIS, FAMILIAL, X-LINKED 2
  GRANULOMATOUS DISEASE, CHRONIC, X-LINKED
  GRANULOMATOUS DISEASE, CHRONIC, X-LINKED, VARIANT


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   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Ferric_reduct















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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