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  Domain Name: INB
Integrin beta subunits (N-terminal portion of extracellular region). Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).
No pairwise interactions found for the domain INB

Total Mutations Found: 33
Total Disease Mutations Found: 20
This domain occurred 8 times on human genes (25 proteins).



  EPIDERMOLYSIS BULLOSA LETALIS, WITH PYLORIC ATRESIA (EB-PA)
  EPIDERMOLYSIS BULLOSA, JUNCTIONAL, WITH PYLORIC ATRESIA
  GLANZMANN THROMBASTHENIA
  LEUKOCYTE ADHESION DEFICIENCY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for INB



















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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