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  Domain Name: IRK
Inward rectifier potassium channel.
No pairwise interactions found for the domain IRK

Total Mutations Found: 128
Total Disease Mutations Found: 91
This domain occurred 15 times on human genes (34 proteins).



  ANDERSEN CARDIODYSRHYTHMIC PERIODIC PARALYSIS
  ATRIAL FIBRILLATION, FAMILIAL, 9
  BARTTER SYNDROME, ANTENATAL, TYPE 2
  DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT,
  DIAB
  DIABETES MELLITUS, PERMANENT NEONATAL
  DIABETES MELLITUS, PERMANENT NEONATAL, INCLUDED
  DIABETES MELLITUS, PERMANENT NEONATAL, WITH NEUROLOGIC FEATURES
  DIABETES MELLITUS, PERMANENT NEONATAL, WITH NEUROLOGIC FEATURES, INCLUDED
  DIABETES MELLITUS, PERMANENT NEONATAL, WITH NEUROLOGIC FEATURES, INCLUDED;;
  DIABETES MELLITUS, TRANSIENT NEONATAL, 3
  DIABETES MELLITUS, TYPE II, AUTOSOMAL DOMINANT, INCLUDED
  DIGENIC
  ELECTROLYTE IMBALANCE
  HYPERALDOSTERONISM, FAMILIAL, TYPE III
  HYPERINSULINEMIC HYPOGLYCEMIA, FAMILIAL, 2
  LEBER CONGENITAL AMAUROSIS 16
  LONG QT SYNDROME 13
  SEIZURES, SENSORINEURAL DEAFNESS, ATAXIA, MENTAL RETARDATION, AND
  SHORT QT SYNDROME 3
  SNOWFLAKE VITREORETINAL DEGENERATION


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for IRK














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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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