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  Domain Name: Peptidase_M2
Angiotensin-converting enzyme. Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.
No pairwise interactions found for the domain Peptidase_M2

Total Mutations Found: 22
Total Disease Mutations Found: 7
This domain occurred 2 times on human genes (6 proteins).



  ANGIOTENSIN I-CONVERTING ENZYME, BENIGN SERUM INCREASE
  RENAL TUBULAR DYSGENESIS


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Peptidase_M2




















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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