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  Domain Name: PseudoU_synth_1
tRNA pseudouridine synthase. Involved in the formation of pseudouridine at the anticodon stem and loop of transfer-RNAs Pseudouridine is an isomer of uridine (5-(beta-D-ribofuranosyl) uracil, and id the most abundant modified nucleoside found in all cellular RNAs. The TruA-like proteins also exhibit a conserved sequence with a strictly conserved aspartic acid, likely involved in catalysis.
No pairwise interactions found for the domain PseudoU_synth_1

Total Mutations Found: 2
Total Disease Mutations Found: 1
This domain occurred 2 times on human genes (2 proteins).



  MYOPATHY, LACTIC ACIDOSIS, AND SIDEROBLASTIC ANEMIA 1


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for PseudoU_synth_1













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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