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  Domain Name: SH3_2
Variant SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.
No pairwise interactions found for the domain SH3_2

Total Mutations Found: 59
Total Disease Mutations Found: 13
This domain occurred 167 times on human genes (419 proteins).



  EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 8
  GRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, CYTOCHROME B-POSITIVE,
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 11
  MENTAL RETARDATION AND MICROCEPHALY WITH PONTINE AND CEREBELLAR HYPOPLASIA
  MYOPATHY, CENTRONUCLEAR, AUTOSOMAL RECESSIVE
  NATIVE AMERICAN MYOPATHY
  TYPE I


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for SH3_2








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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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