LOG for the DS-Score FTP directory http://bioinf.umbc.edu/ds-score/ftp/ This FTP directory contains two files: 1. precomputed_DS-Scores.tar.gz 2. DS-Score_programs.tar.gz precomputed_DS-Scores.tar.gz - Contains the DS-Score runs for Cancer and Non-cancer as described in the paper. - For the position-based and feature-based scores, the directory hierarchies are: - precomputed_DS-Scores ->position-based -> CANCER -> NONCANCER -> feature-based -> CANCER -> NONCANCER DS-Score_programs.tar.gz - Contains the programs required to run the DS-Score program. This includes the directory, "DS_library" containing all databases needed to run the DS-Score program including the Cancer and Non-cancer mutation databases. Instructions for running the DS-Score program - All programs require perl 5 or higher - All programs have a -d flag for specifying the directory in which the program is to run. This must be the directory containing the scripts and the DS_library directory. - Steps: perl run_domain_positions_by position.pl -d [directory] perl run_ds_score.pl -d [directory] Instructions for creating a randomized dataset - As described in the paper, this method was applied 1000 times to each mutation set. - To create a random dataset, specify the directory and the mutation file you want to randomize: perl randomize_mutation_set.pl -d [directory] -m [path and filename of mutation database]