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Results for the Protein: NP_001177728
299829210

serine/threonine-protein kinase PLK4 isoform 2 [Homo sapiens]
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

STKc_p38 - cd07851
STKc_PAK3 - cd06656
STKc_PAK6 - cd06659
STKc_PAK5 - cd06658
STKc_Sty1_Hog1 - cd07856
STKc_p38alpha_MAPK14 - cd07877
PTKc_FGFR4 - cd05099
STKc_CDK9 - cd07865
STKc_p38beta_MAPK11 - cd07878
STKc_PAK4 - cd06657
STKc_p38gamma_MAPK12 - cd07880
STKc_ROCK - cd05596
STKc_ROCK2 - cd05621
STKc_PAK2 - cd06655
STKc_TAO3 - cd06633
PKc_MKK7 - cd06618
STKc_PAK1 - cd06654
STKc_myosinIIIB - cd06639
STKc_PAK_II - cd06648
STKc_PAK_I - cd06647
STKc_MAP4K5 - cd06646
STKc_STK10_LOK - cd06644
STKc_CDK10 - cd07845
S_TKc - smart00220
STKc_MAP4K3 - cd06645
STKc_PAK - cd06614
STKc_TAO1 - cd06635
STKc_myosinIIIA - cd06638
STKc_CDK6 - cd07862
STKc_JNK - cd07850
STKc_MAP4K4_6 - cd06636
PTKc_EphR_A2 - cd05063
STKc_ASK - cd06624
PTKc_EGFR_like - cd05057
STKc_MAPK4_6 - cd07854
STKc_MAPK15 - cd07852
STKc_PFTAIRE2 - cd07870
PTK_Ryk - cd05043
STKc_TNIK - cd06637
PTKc_FAK - cd05056
PTKc_PDGFR - cd05055
STKc_ROCK1 - cd05622
PTKc_Ror - cd05048
STKc_CDK12 - cd07864
STKc_MST3 - cd06641
STKc_TEY_MAPK_plant - cd07858
STKc_SLK - cd06643
STKc_CDK5 - cd07839
PTKc_Jak_rpt2 - cd05038
STKc_STK25-YSK1 - cd06642
PKc_MAPKK_Pek1_like - cd06621
PTKc_ALK_LTK - cd05036
STKc_MST4 - cd06640
PKc_MEK1 - cd06650
PKc_MEK2 - cd06649
PKc_MAPKK_Byr1_like - cd06620
PTKc_Btk_Bmx - cd05113
PTKc_EGFR - cd05108
STKc_BUR1 - cd07866
PKc_MKK4 - cd06616
PTKc_Itk - cd05112
STKc_PCTAIRE_like - cd07844
STKc_Nek8 - cd08220
STKc_PCTAIRE1 - cd07873
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE3 - cd07871
STKc_PFTAIRE1 - cd07869
PTKc_Abl - cd05052
PTKc_EphR_B - cd05065
PTKc_Frk_like - cd05068
PTKc_FGFR - cd05053
PTKc_Trk - cd05049
PTKc_InsR_like - cd05032
PTK_HER3 - cd05111
PTKc_Fyn_Yrk - cd05070
PTKc_EphR - cd05033
PTKc_Lyn - cd05072
PTKc_TrkB - cd05093
PTKc_TrkA - cd05092
PTKc_HER2 - cd05109
PTKc_Csk - cd05082
PTKc_Chk - cd05083
PTKc_Tie2 - cd05088
STKc_Nek6 - cd08228
STKc_Nek6_Nek7 - cd08224
STKc_Nek7 - cd08229
PTKc_Csk_like - cd05039
PTKc_Tie1 - cd05089
PTKc_Tec_Rlk - cd05114
STKc_CDC2L1 - cd07843
PKc_MKK3_6 - cd06617
STKc_MST3_like - cd06609
PKc_MAPKK_plant_like - cd06623
PKc_MEK - cd06615
PKc_MKK5 - cd06619
STKc_MST1_2 - cd06612
STKc_MEKK3_like - cd06625
STKc_myosinIII_like - cd06608
STKc_OSR1_SPAK - cd06610
STKc_MAP4K3_like - cd06613
STKc_CDKL1_4 - cd07847
STKc_CDKL5 - cd07848
STKc_ERK1_2_like - cd07849
SPS1 - COG0515
PKc_MAPKK - cd06605
STKc_CDKL2_3 - cd07846
STKc_CdkB_plant - cd07837
STKc_MEKK3_like_1 - cd06653
STKc_NAK1_like - cd06917
STKc_CDKL - cd07833
STKc_MEKK2 - cd06652
PKc_MAPKK_PBS2_like - cd06622
STKc_ROCK_NDR_like - cd05573
STKc_phototropin_lik - cd05574
STKc_PDK1 - cd05581
STKc_DMPK_like - cd05597
PTKc_Srm_Brk - cd05148
PTKc_Hck - cd05073
STKc_LATS2 - cd05626
PTKc_Src_like - cd05034
PTKc_Yes - cd05069
PTKc_Src - cd05071
STKc_LATS - cd05598
PTKc_Musk - cd05050
STKc_MRCK_beta - cd05624
STKc_NDR1 - cd05628
STKc_NDR2 - cd05627
STKc_CRIK - cd05601
STKc_MRCK_alpha - cd05623
STKc_NDR_like_fungal - cd05629
STKc_Sid2p_Dbf2p - cd05600
STKc_NDR_like - cd05599
STKc_MAST - cd05609
STKc_PKA - cd05580
STKc_PRKX_like - cd05612
STKc_CDK1_euk - cd07861
STKc_MPK1 - cd07857
STKc_TDY_MAPK_plant - cd07859
STKc_CDK2_3 - cd07860
STKc_CDK4 - cd07863
STKc_Pho85 - cd07836
STKc_CDK7 - cd07841
STKc_Nek - cd08215
STKc_CDK8_like - cd07842
STKc_NLK - cd07853
STKc_Nek4 - cd08223
STKc_FA2-like - cd08529
STKc_CNK2-like - cd08530
STKc_MAPK - cd07834
STKc_Nek10 - cd08528
STKc_Nek5 - cd08225
STKc_Nek1 - cd08218
STKc_Nek3 - cd08219
STKc_Nek11 - cd08222
STKc_Nek2 - cd08217
STKc_Cdc7_like - cd06627
STKc_MSK2_N - cd05614
STKc_CCRK - cd07832
STKc_cPKC_beta - cd05616
STKc_cPKC - cd05587
STKc_MSK1_N - cd05613
STKc_GRK4_like - cd05605
PTKc_Tec_like - cd05059
PKc_STE - cd05122
STKc_Yank1 - cd05578
STKc_MSK_N - cd05583
STKc_GRK6 - cd05630
STKc_cPKC_alpha - cd05615
STKc_MEKK1 - cd06630
STKc_GRK5 - cd05632
STKc_TAO2 - cd06634
STKc_MEKK3 - cd06651
STKc_MAPKKK - cd06606
STKc_YSK4 - cd06631
STKc_GRK4 - cd05631
STKc_TAO - cd06607
STKc_MAPKKK_Byr2_lik - cd06628
STKc_ERK5 - cd07855
STKc_CDK9_like - cd07840
Pkinase - pfam00069
STKc_CDK4_6_like - cd07838
STYKc - smart00221
STKc_MOK - cd07831
TyrKc - smart00219
Pkinase_Tyr - pfam07714
PTKc_Tyk2_rpt2 - cd05080
PTKc_Jak2_Jak3_rpt2 - cd05081
STKc_PKN - cd05589
STKc_LATS1 - cd05625
STKc_CDK1_like - cd07835
PTKc_Axl_like - cd05035
STKc_CMGC - cd05118
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CDK_like - cd07829
STKc_MAK_like - cd07830
STKc_MEKK1_plant - cd06632
PK_STRAD - cd08216
STKc_SLK_like - cd06611
STKc_p70S6K - cd05584
STKc_MEKK4 - cd06626
STKc_SGK1 - cd05602
STKc_PKB_gamma - cd05593
STKc_SGK2 - cd05603
STKc_PKB_alpha - cd05594
STKc_nPKC_delta - cd05620
STKc_nPKC_theta_delt - cd05592
STKc_nPKC_theta - cd05619
STKc_aPKC_iota - cd05618
STKc_aPKC_zeta - cd05617
STKc_SGK3 - cd05604
STKc_PKB_beta - cd05595
PTKc_Ack_like - cd05040
PTKc - cd00192
PTKc_Fer - cd05085
STKc_nPKC_epsilon - cd05591
PTKc_c-ros - cd05044
PTKc_Syk_like - cd05060
PTKc_Tie - cd05047
PTKc_Syk - cd05116
PTKc_Fes - cd05084
STKc_SGK - cd05575
STKc_RSK_N - cd05582
STKc_aPKC - cd05588
STKc_nPKC_eta - cd05590
PTKc_Fes_like - cd05041
STKc_PKB - cd05571
STKc_PKC - cd05570
STKc_GRK3 - cd05633
STKc_beta_ARK - cd05606
STKc_Nek9 - cd08221
STKc_GRK1 - cd05608
STKc_YPK1_like - cd05585
STKc_GRK7 - cd05607
PTKc_Zap-70 - cd05115
STKc_AGC - cd05123
PTKc_Aatyk - cd05042
PKc - cd00180
STKc_GRK - cd05577
STKc_Sck1_like - cd05586
STKc_MAST_like - cd05579
STKc_cGK_PKG - cd05572
STKc_Rim15_like - cd05611
KIND - smart00750
POLO_box - pfam00659




Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
PTKc_FGFR4cd050990.00091250
STKc_ROCKcd055963e-061297
STKc_ROCK2cd056211.7e-051295
PKc_MKK7cd066181.4e-091253
STKc_TAO3cd066330.000541276
STKc_myosinIIIBcd066391.9e-061234
STKc_PAK_Icd066474.1e-071259
STKc_PAK_IIcd066487.5e-111245
STKc_PAK1cd066549.7e-071261
STKc_PAK2cd066551.3e-061255
STKc_PAK4cd066576.8e-051252
STKc_PAK5cd066583.5e-051251
STKc_PAK6cd066598.5e-091261
STKc_PAK3cd066569.2e-081267
STKc_p38cd078511.7e-091267
STKc_Sty1_Hog1cd078562.3e-081265
STKc_p38alpha_MAPK14cd078770.00031295
STKc_p38beta_MAPK11cd078780.000271272
STKc_p38gamma_MAPK12cd078803.7e-051272
STKc_CDK9cd078652e-091233
STKc_PAKcd066141.1e-162247
STKc_TAO1cd066357.8e-062276
STKc_myosinIIIAcd066381.7e-072233
STKc_MAP4K3cd066456.1e-082232
STKc_MAP4K5cd066468.7e-072232
STKc_STK10_LOKcd066443.6e-082253
STKc_CDK10cd078452.9e-122244
PTKc_EphR_A2cd050630.000363232
STKc_ASKcd066242.9e-103233
STKc_MAP4K4_6cd066361.1e-053233
STKc_JNKcd078500.000193262
STKc_CDK6cd078625.1e-053233
PTKc_EGFR_likecd050571.6e-054225
PTK_Rykcd050430.000195213
PTKc_PDGFRcd050559.5e-055214
PTKc_FAKcd050569.9e-075232
STKc_ROCK1cd056229.8e-065296
STKc_TNIKcd066371.1e-075233
STKc_MAPK15cd078521.9e-105258
STKc_MAPK4_6cd078544.5e-085270
STKc_PFTAIRE2cd078704.1e-075233
PTKc_Rorcd050485.7e-056188
STKc_CDK12cd078645.5e-106233
PTKc_ALK_LTKcd050364.3e-077233
PTKc_Jak_rpt2cd050382.3e-077235
PKc_MAPKK_Pek1_likecd066215.2e-077245
STKc_MST4cd066402.9e-087255
STKc_STK25-YSK1cd066429.4e-097254
STKc_SLKcd066431.4e-087250
STKc_MST3cd066411.8e-077255
STKc_CDK5cd078392.2e-097233
STKc_TEY_MAPK_plantcd078581.3e-067278
PTKc_InsR_likecd050321.4e-068230
PTKc_EphRcd050336.9e-068232
PTKc_Trkcd050494.4e-068230
PTKc_Ablcd050524e-058232
PTKc_FGFRcd050531.3e-058214
PTKc_EphR_Bcd050650.000618232
PTKc_Frk_likecd050689.9e-088231
PTKc_Fyn_Yrkcd050700.000278231
PTKc_Lyncd050722e-058231
PTKc_Cskcd050820.000258231
PTKc_Chkcd050830.000118236
PTKc_Tie2cd050882.7e-058250
PTKc_TrkAcd050920.000228238
PTKc_TrkBcd050930.000348245
PTKc_HER2cd051090.000578244
PTK_HER3cd051110.000468225
PTKc_Itkcd051121e-068232
PTKc_EGFRcd051080.000148283
PTKc_Btk_Bmxcd051133.7e-068228
PKc_MKK4cd066161.8e-068252
PKc_MAPKK_Byr1_likecd066201.4e-068248
PKc_MEK1cd066500.0018266
PKc_MEK2cd066490.000948260
STKc_BUR1cd078661.4e-128233
STKc_PFTAIRE1cd078690.000118246
STKc_PCTAIRE3cd078716.8e-088233
STKc_PCTAIRE2cd078721.4e-068261
STKc_PCTAIRE1cd078736.8e-068249
STKc_PCTAIRE_likecd078442e-088263
STKc_Nek8cd082202.8e-098233
PTKc_Csk_likecd050394.4e-079231
PTKc_Tie1cd050892.2e-059256
PTKc_Tec_Rlkcd051140.00019232
STKc_CDC2L1cd078431e-129233
STKc_Nek6_Nek7cd082242.9e-119236
STKc_Nek7cd082292.1e-099236
STKc_Nek6cd082282.1e-079236
PTKc_Src_likecd050341.1e-0910231
PTKc_Muskcd050501.2e-0510235
PTKc_Yescd050695.9e-0510231
PTKc_Srccd050710.0001110233
PTKc_Hckcd050730.0001210231
PTKc_Srm_Brkcd051483.2e-0910231
STKc_ROCK_NDR_likecd055735.6e-1510305
STKc_phototropin_likcd055746.4e-1310252
STKc_PDK1cd055817.2e-4310233
STKc_DMPK_likecd055974.7e-0810294
STKc_LATScd055981.5e-0710281
STKc_CRIKcd056017.3e-1210287
STKc_NDR_likecd055999.9e-1010318
STKc_Sid2p_Dbf2pcd056008.3e-0910277
STKc_MASTcd056091.7e-1010306
STKc_PRKX_likecd056121.9e-1610260
STKc_PKAcd055808.2e-1910269
STKc_MRCK_alphacd056232.9e-0710314
STKc_MRCK_betacd056244.1e-0710283
STKc_NDR1cd056287.3e-0710318
STKc_NDR_like_fungalcd056292.8e-0610321
STKc_NDR2cd056272.4e-0510316
STKc_LATS2cd056263.9e-0510281
PKc_MAPKKcd066054.8e-1010238
STKc_MST3_likecd066091e-1610252
STKc_myosinIII_likecd066081e-1110233
STKc_OSR1_SPAKcd066103.6e-1210233
STKc_MST1_2cd066129.1e-1610233
STKc_MAP4K3_likecd066137.5e-1410232
PKc_MEKcd066156.5e-0910251
PKc_MKK3_6cd066174.3e-0910252
PKc_MKK5cd066190.0001410255
PKc_MAPKK_PBS2_likecd066221.1e-0710289
PKc_MAPKK_plant_likecd066231e-1610239
STKc_MEKK3_likecd066251.2e-1510233
STKc_MEKK2cd066525.4e-0710234
STKc_MEKK3_like_1cd066537.5e-0810233
STKc_NAK1_likecd069173e-1110249
STKc_CDKLcd078333.8e-1010233
STKc_CdkB_plantcd078378e-1310234
STKc_CDKL2_3cd078461.7e-0910233
STKc_CDKL1_4cd078471.2e-0610233
STKc_CDKL5cd078480.0007610233
STKc_ERK1_2_likecd078491.7e-0810264
SPS1COG05158e-4510393
PTKc_Tec_likecd050599e-0811229
PKc_STEcd051223.6e-1811232
STKc_Yank1cd055781.2e-1711233
STKc_MSK_Ncd055832.4e-1111250
STKc_GRK4_likecd056054.9e-0911255
STKc_MSK1_Ncd056131.3e-0811253
STKc_MSK2_Ncd056141.9e-1011283
STKc_cPKC_alphacd056151.6e-1011282
STKc_cPKC_betacd056165.5e-0911313
STKc_cPKCcd055874.5e-1811309
STKc_GRK6cd056301.4e-0511255
STKc_GRK5cd056321.6e-0711255
STKc_GRK4cd056312.3e-0611255
STKc_TAOcd066075.6e-0711276
STKc_Cdc7_likecd066274e-2111233
STKc_MAPKKK_Byr2_likcd066281.4e-1011233
STKc_MAPKKKcd066064e-3011233
STKc_YSK4cd066315.2e-1111233
STKc_MEKK1cd066301.5e-1011234
STKc_TAO2cd066349.5e-0611277
STKc_MEKK3cd066512.5e-1011235
STKc_CCRKcd078322.3e-1311234
STKc_MAPKcd078348.3e-1211261
STKc_CDK7cd078416.5e-1311245
STKc_CDK8_likecd078424.4e-0811233
STKc_Pho85cd078364.6e-0711233
STKc_NLKcd078535e-0911305
STKc_CDK2_3cd078601.8e-0611233
STKc_CDK1_eukcd078613.4e-0611233
STKc_CDK4cd078638.3e-0611233
STKc_MPK1cd078571.8e-0911262
STKc_TDY_MAPK_plantcd078594.7e-0611320
STKc_Nekcd082154e-3111233
STKc_Nek2cd082172.3e-1311233
STKc_Nek1cd082181.6e-2111233
STKc_Nek3cd082191.2e-2111233
STKc_Nek11cd082221.1e-1111233
STKc_Nek5cd082252e-2211233
STKc_Nek4cd082231.8e-1211233
STKc_Nek10cd085281.7e-0711230
STKc_FA2-likecd085292.7e-1311227
STKc_CNK2-likecd085301e-1411233
PTKc_Axl_likecd050350.0008512232
PTKc_Tyk2_rpt2cd050800.0002112236
PTKc_Jak2_Jak3_rpt2cd050813.9e-0612235
STKc_CMGCcd051181.7e-1512233
STKc_PKNcd055891.3e-1112305
STKc_LATS1cd056251.4e-0512312
STKc_MAPKKK_Bck1_likcd066291.9e-1012233
STKc_CDK_likecd078293.1e-2012233
STKc_MAK_likecd078308.4e-1412233
STKc_CDK1_likecd078353.1e-0712233
STKc_MOKcd078314.4e-1412233
STKc_CDK4_6_likecd078387.5e-1412233
STKc_CDK9_likecd078407e-1612233
STKc_ERK5cd078552e-1012265
STKc_MEKK1_plantcd066322.1e-1413233
PK_STRADcd082160.0001513249
STKc_SLK_likecd066115.8e-1214250
STKc_p70S6Kcd055844.1e-1815307
STKc_MEKK4cd066265.3e-1315233
PTKccd001922.8e-1216232
PTKc_Ack_likecd050406e-0916234
PTKc_c-roscd050440.0002316233
PTKc_Tiecd050475.2e-0516229
PTKc_Syk_likecd050603.2e-0716219
PTKc_Fescd050840.0001216233
PTKc_Fercd050851.5e-0516233
PTKc_Sykcd051162.7e-0516233
PTKc_Fes_likecd050414.5e-0916233
STKc_PKCcd055706.1e-1616281
STKc_PKBcd055714.6e-1316307
STKc_SGKcd055757.5e-0916287
STKc_RSK_Ncd055821e-1216281
STKc_aPKCcd055886.1e-1016309
STKc_nPKC_etacd055907.6e-1116306
STKc_nPKC_epsiloncd055919.1e-1116297
STKc_nPKC_theta_deltcd055923.8e-1516307
STKc_PKB_gammacd055931.1e-0916326
STKc_PKB_alphacd055946e-1116311
STKc_PKB_betacd055956.7e-1016301
STKc_SGK1cd056023.1e-0616314
STKc_SGK2cd056032.4e-0816313
STKc_SGK3cd056045.1e-0616289
STKc_aPKC_zetacd056173.4e-0916309
STKc_aPKC_iotacd056181.2e-0716309
STKc_nPKC_thetacd056194.6e-1216310
STKc_nPKC_deltacd056201.8e-0716314
STKc_beta_ARKcd056061.4e-0717253
STKc_GRK3cd056338.3e-0717262
STKc_Nek9cd082215.3e-1217233
PKccd001803.7e-5618231
PTKc_Aatykcd050421.1e-0618216
PTKc_Zap-70cd051152.7e-0518236
STKc_AGCcd051239e-4018233
STKc_GRKcd055776.8e-1218249
STKc_cGK_PKGcd055723.7e-1718239
STKc_MAST_likecd055791.9e-1918238
STKc_Sck1_likecd055864.7e-0718362
STKc_YPK1_likecd055855.8e-0918295
STKc_GRK1cd056082.5e-0818253
STKc_GRK7cd056071.7e-0618258
STKc_Rim15_likecd056111.5e-0720235
Pkinasepfam000693.9e-6012233
POLO_boxpfam006591e-14860924
S_TKcsmart002204.9e-622233
Pkinase_Tyrpfam077142e-1512233
TyrKcsmart002193.1e-1212233
STYKcsmart002212.6e-4912233
KINDsmart007508.1e-0669241

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs17012739 Polymorphismp.GLU798ASPN/A
dbSNPrs3811740 Polymorphismp.SER200THRN/A
dbSNPrs61735390 Polymorphismp.THR796METN/A



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