Results for the protein: NP

Results for the Protein: NP_001073285

119395738

3643

INSR

NCBI

insulin receptor isoform Short preproprotein [Homo sapiens]

Known Diseases associated with this Protein:
  DIABETES MELLITUS, INSULIN-RESISTANT
  DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
  DIABETES MELLITUS, NONINSULIN-DEPENDENT
  DONOHUE SYNDROME
  HYPERINSULINEMIC HYPOGLYCEMIA, FAMILIAL, 5
  INSULIN RESISTANCE
  INSULIN RESISTANCE, INCLUDED
  RABSON-MENDENHALL SYNDROME

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Tips:

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RefSeq Protein: NP_001073285

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FN3	cd00063	7.5e-09	838	932
PTKc_CSF-1R	cd05106	1e-38	977	1283
PTKc_Kit	cd05104	1.2e-29	978	1282
PTKc_PDGFR_alpha	cd05105	1.6e-18	979	1285
PTKc_PDGFR	cd05055	7.5e-25	980	1282
PTKc_PDGFR_beta	cd05107	7.4e-14	980	1283
STKc_PAK1	cd06654	1.3e-05	983	1300
STKc_PAK_I	cd06647	0.00017	984	1301
STKc_PAK3	cd06656	1.4e-05	984	1303
STKc_PAK6	cd06659	2e-06	989	1299
STKc_TAO1	cd06635	0.00044	990	1318
STKc_PAK4	cd06657	0.0004	990	1313
STKc_PAK5	cd06658	0.00047	990	1293
STKc_PAK_II	cd06648	1.1e-06	991	1290
STKc_TAO2	cd06634	2.1e-05	992	1319
STKc_myosinIIIA	cd06638	1e-05	994	1283
STKc_p38	cd07851	2.7e-05	994	1341
PTKc_FGFR1	cd05098	1.9e-63	996	1288
PTKc_FGFR2	cd05101	1.6e-61	997	1289
PTKc_FGFR	cd05053	8e-83	998	1283
PTKc_FGFR4	cd05099	4.2e-65	998	1301
PTKc_EGFR	cd05108	9e-33	998	1325
PTKc_HER4	cd05110	2.3e-31	998	1311
PTKc_Tie2	cd05088	7.6e-40	999	1304
STKc_STK10_LOK	cd06644	9.9e-07	999	1305
PTKc_FGFR3	cd05100	6.3e-56	1000	1311
STKc_ASK	cd06624	2.9e-09	1000	1283
STKc_PAK	cd06614	2.6e-11	1001	1290
STKc_MEKK3_like	cd06625	4.7e-09	1001	1280
PKc_MKK7	cd06618	7.1e-07	1002	1297
STKc_PAK2	cd06655	3.5e-05	1002	1304
PTKc_VEGFR	cd05054	3.4e-39	1003	1285
PTKc_VEGFR3	cd05102	2.6e-48	1003	1285
PTKc_VEGFR2	cd05103	2.6e-38	1003	1285
STKc_TAO	cd06607	0.00039	1003	1318
STKc_MAPK15	cd07852	3.8e-05	1003	1328
PTKc_InsR_like	cd05032	4.3e-226	1004	1280
PTKc_Src_like	cd05034	1.5e-67	1004	1281
PTKc_Csk_like	cd05039	9.5e-46	1004	1278
PTKc_ALK_LTK	cd05036	5e-109	1004	1280
PTKc_Abl	cd05052	2.8e-69	1004	1282
PTKc_FAK	cd05056	1.2e-78	1004	1286
PTKc_InsR	cd05061	1.9e-251	1004	1291
PTKc_IGF-1R	cd05062	8.8e-216	1004	1280
PTKc_Lck_Blk	cd05067	3.1e-57	1004	1281
PTKc_Frk_like	cd05068	1.9e-74	1004	1281
PTKc_Yes	cd05069	1.4e-52	1004	1281
PTKc_Fyn_Yrk	cd05070	9.2e-52	1004	1281
PTKc_Src	cd05071	3.4e-50	1004	1283
PTKc_Lyn	cd05072	1.2e-59	1004	1281
PTKc_Csk	cd05082	7.7e-59	1004	1281
PTKc_Chk	cd05083	1.1e-58	1004	1281
PTKc_Hck	cd05073	8.6e-57	1004	1281
PTKc_HER2	cd05109	1.3e-42	1004	1291
PTKc_Srm_Brk	cd05148	1.5e-59	1004	1285
STKc_ERK1_2_like	cd07849	0.0003	1004	1314
STKc_ERK5	cd07855	0.00027	1004	1312
STKc_TEY_MAPK_plant	cd07858	0.0002	1004	1351
STKc_CDK12	cd07864	1.9e-07	1004	1305
PTK_CCK4	cd05046	5.5e-61	1005	1280
PTKc_Trk	cd05049	1.3e-101	1005	1280
PTKc_Musk	cd05050	4.6e-100	1005	1280
PTKc_DDR	cd05051	1.3e-69	1005	1280
PTKc_Ror	cd05048	1e-79	1005	1281
PTKc_EphR_A2	cd05063	4.5e-67	1005	1282
PTKc_EphR_A10	cd05064	1.4e-57	1005	1282
PTKc_EphR_B	cd05065	7.4e-57	1005	1282
PTKc_Ror1	cd05090	1.6e-61	1005	1281
PTKc_TrkA	cd05092	3.5e-88	1005	1288
PTKc_TrkB	cd05093	5.1e-81	1005	1290
PTKc_TrkC	cd05094	2.3e-57	1005	1288
PTKc_DDR2	cd05095	1.4e-68	1005	1280
PTKc_DDR1	cd05096	3.7e-56	1005	1280
PTKc_DDR_like	cd05097	1.8e-66	1005	1280
PTKc_Ror2	cd05091	1.5e-58	1005	1281
PKc_MAPKK_Byr1_like	cd06620	5e-05	1005	1287
STKc_MAP4K3	cd06645	6.2e-06	1005	1282
STKc_MAP4K5	cd06646	5.8e-06	1005	1279
STKc_SLK	cd06643	1.9e-06	1005	1299
PTKc_EphR	cd05033	1.2e-76	1006	1282
PTKc_Jak_rpt2	cd05038	1.6e-53	1006	1283
PTK_Ryk	cd05043	5.3e-36	1006	1282
PTKc_Tec_like	cd05059	4.8e-53	1006	1279
PTKc_EphR_A	cd05066	2e-62	1006	1283
PTKc_Jak2_Jak3_rpt2	cd05081	7.5e-35	1006	1283
PTK_HER3	cd05111	5.8e-27	1006	1290
PTKc_Itk	cd05112	4.6e-60	1006	1279
PTKc_Tec_Rlk	cd05114	7.5e-60	1006	1279
PTKc_Btk_Bmx	cd05113	4.3e-65	1006	1279
STKc_CDK10	cd07845	4e-08	1006	1287
STKc_BUR1	cd07866	5.7e-06	1006	1286
PTKc_EGFR_like	cd05057	9.9e-49	1007	1290
STKc_MAP4K3_like	cd06613	2.3e-10	1007	1282
PKc_MKK4	cd06616	9.4e-06	1007	1296
STKc_TNIK	cd06637	0.00081	1007	1286
STKc_MST4	cd06640	5.4e-07	1007	1298
STKc_MST3	cd06641	9.8e-07	1007	1298
STKc_STK25-YSK1	cd06642	3.6e-08	1007	1301
STKc_PCTAIRE_like	cd07844	0.00013	1007	1310
STKc_PFTAIRE2	cd07870	0.00055	1007	1316
STKc_SLK_like	cd06611	1.5e-06	1008	1308
STKc_MST1_2	cd06612	1.5e-08	1008	1272
STKc_MEKK3_like_1	cd06653	8.4e-05	1008	1280
STKc_MEKK2	cd06652	0.00048	1008	1283
STKc_Nek6_Nek7	cd08224	6.5e-07	1008	1283
PTKc_Jak1_rpt2	cd05079	2.3e-31	1009	1282
PTKc_Tie1	cd05089	2.3e-37	1009	1301
STKc_ROCK_NDR_like	cd05573	3.8e-05	1009	1352
STKc_PKA	cd05580	0.00027	1009	1312
STKc_MAST	cd05609	4.1e-05	1009	1338
STKc_PRKX_like	cd05612	3.3e-05	1009	1313
PKc_MAPKK	cd06605	4.1e-05	1009	1276
STKc_MST3_like	cd06609	4.8e-10	1009	1290
STKc_OSR1_SPAK	cd06610	4.1e-09	1009	1286
STKc_myosinIII_like	cd06608	1e-06	1009	1278
PKc_MEK	cd06615	0.00024	1009	1299
PKc_MKK3_6	cd06617	7.3e-08	1009	1298
PKc_MAPKK_PBS2_like	cd06622	5.3e-06	1009	1320
PKc_MAPKK_plant_like	cd06623	4.6e-11	1009	1276
PKc_MAPKK_Pek1_like	cd06621	1.8e-05	1009	1282
STKc_CDKL	cd07833	0.00052	1009	1286
STKc_CdkB_plant	cd07837	7.3e-08	1009	1287
STKc_CDKL2_3	cd07846	0.0001	1009	1283
STKc_CDK6	cd07862	1.4e-05	1009	1310
STKc_CDKL1_4	cd07847	2e-05	1009	1315
STKc_Nek6	cd08228	3.6e-05	1009	1284
STKc_Nek7	cd08229	2.1e-06	1009	1284
SPS1	COG0515	3.7e-18	1009	1370
PTKc_RET	cd05045	1.7e-64	1010	1285
PKc_STE	cd05122	7.4e-13	1010	1282
STKc_cPKC	cd05587	1.6e-05	1010	1353
STKc_GRK4_like	cd05605	1.4e-07	1010	1313
STKc_GRK6	cd05630	3.2e-05	1010	1313
STKc_GRK5	cd05632	1e-05	1010	1305
STKc_GRK4	cd05631	3.9e-06	1010	1302
STKc_MAPKKK	cd06606	4.5e-19	1010	1272
STKc_MAPKKK_Byr2_lik	cd06628	6.6e-08	1010	1283
STKc_Cdc7_like	cd06627	4.3e-11	1010	1272
STKc_MEKK3	cd06651	6.6e-07	1010	1282
STKc_MAPK	cd07834	6.8e-08	1010	1312
STKc_Pho85	cd07836	1.2e-05	1010	1310
STKc_CDK5	cd07839	1.7e-05	1010	1310
STKc_NLK	cd07853	0.00054	1010	1342
STKc_CCRK	cd07832	1.1e-08	1010	1287
STKc_MPK1	cd07857	4.3e-05	1010	1315
STKc_CDK7	cd07841	1.4e-07	1010	1284
STKc_CDK2_3	cd07860	0.0001	1010	1310
STKc_CDK1_euk	cd07861	0.00033	1010	1310
STKc_CDK4	cd07863	4.4e-06	1010	1310
STKc_Nek	cd08215	7.2e-14	1010	1280
STKc_Nek1	cd08218	6.9e-06	1010	1278
STKc_Nek3	cd08219	8.3e-09	1010	1277
STKc_Nek2	cd08217	1.9e-09	1010	1280
STKc_Nek9	cd08221	4.3e-06	1010	1279
STKc_Nek11	cd08222	1.7e-06	1010	1283
STKc_Nek4	cd08223	2.1e-05	1010	1282
STKc_Nek5	cd08225	4.8e-05	1010	1283
STKc_Nek8	cd08220	3.4e-05	1010	1283
STKc_Nek10	cd08528	4.5e-07	1010	1280
STKc_CNK2-like	cd08530	1.3e-08	1010	1278
PTKc_Axl_like	cd05035	2.5e-82	1011	1282
PTKc_Axl	cd05075	1.6e-67	1011	1282
PTKc_Tyk2_rpt2	cd05080	5.8e-28	1011	1283
PTKc_Tyro3	cd05074	1.6e-73	1011	1282
STKc_PKN	cd05589	6.3e-05	1011	1333
STKc_CDK1_like	cd07835	2e-06	1011	1309
STKc_CMGC	cd05118	7.1e-09	1012	1286
STKc_Yank1	cd05578	4.4e-06	1012	1286
STKc_NAK1_like	cd06917	3.3e-05	1012	1279
STKc_CDK_like	cd07829	1.6e-11	1012	1286
STKc_MAK_like	cd07830	5.5e-09	1012	1272
PK_STRAD	cd08216	0.001	1012	1284
STKc_PDK1	cd05581	8e-12	1013	1292
STKc_CRIK	cd05601	0.00088	1013	1342
STKc_MEKK4	cd06626	6.2e-06	1013	1283
STKc_MOK	cd07831	4.1e-06	1013	1286
STKc_CDK9_like	cd07840	3.6e-06	1013	1271
STKc_CDK4_6_like	cd07838	9.9e-09	1013	1272
STKc_FA2-like	cd08529	5.2e-11	1013	1286
STKc_RSK_N	cd05582	1.4e-05	1014	1346
STKc_MAPK4_6	cd07854	0.00044	1014	1328
PTKc	cd00192	2.9e-147	1015	1279
PTK_Jak_rpt1	cd05037	1e-11	1015	1279
PTKc_Fes_like	cd05041	3e-62	1015	1280
PTKc_Aatyk	cd05042	1.1e-40	1015	1280
PTKc_c-ros	cd05044	8.2e-112	1015	1280
PTKc_Ack_like	cd05040	3.4e-57	1015	1280
PTKc_Met_Ron	cd05058	1.4e-76	1015	1284
PTKc_Syk_like	cd05060	9.2e-68	1015	1283
PTK_Jak1_rpt1	cd05077	1.8e-10	1015	1279
PTK_Jak2_Jak3_rpt1	cd05078	9.1e-13	1015	1279
PTKc_Fes	cd05084	4.7e-69	1015	1280
PTKc_Aatyk2	cd05086	1.3e-39	1015	1280
PTKc_Aatyk1_Aatyk3	cd05087	2.1e-51	1015	1280
PTK_Tyk2_rpt1	cd05076	2.8e-07	1015	1279
PTKc_Syk	cd05116	7.6e-49	1015	1283
STKc_PKC	cd05570	4.6e-06	1015	1315
STKc_PKB	cd05571	2e-05	1015	1342
STKc_nPKC_eta	cd05590	0.00074	1015	1353
STKc_nPKC_epsilon	cd05591	0.00013	1015	1353
STKc_nPKC_theta_delt	cd05592	1e-05	1015	1354
STKc_PKB_gamma	cd05593	0.0005	1015	1326
STKc_nPKC_theta	cd05619	1.3e-05	1015	1354
STKc_MEKK1	cd06630	7.2e-08	1015	1287
STKc_MEKK1_plant	cd06632	5.3e-09	1015	1272
PTKc_Zap-70	cd05115	5e-44	1016	1283
STKc_MAPKKK_Bck1_lik	cd06629	2.6e-08	1016	1272
PKc	cd00180	1.7e-65	1017	1278
PTKc_Tie	cd05047	2e-47	1017	1283
PTKc_Fer	cd05085	3.4e-64	1017	1280
STKc_AGC	cd05123	2.7e-07	1017	1286
STKc_cGK_PKG	cd05572	8.5e-06	1017	1279
STKc_GRK	cd05577	9.9e-07	1017	1301
STKc_MAST_like	cd05579	4.5e-05	1017	1291
STKc_beta_ARK	cd05606	5.4e-05	1017	1306
STKc_GRK7	cd05607	6.2e-05	1017	1306
STKc_GRK1	cd05608	1.3e-07	1017	1304
STKc_YSK4	cd06631	2.1e-08	1017	1283
Recep_L_domain	pfam01030	1.9e-44	52	164
Furin-like	pfam00757	1.9e-81	179	340
Recep_L_domain	pfam01030	7.1e-48	359	474
Pkinase	pfam00069	1e-35	1011	1278
FU	smart00261	3.2e-12	225	274
FN3	smart00060	1.3e-07	838	922
Pkinase_Tyr	pfam07714	7.6e-155	1011	1278
TyrKc	smart00219	6.1e-140	1011	1278
STYKc	smart00221	1.5e-51	1011	1286
S_TKc	smart00220	1.8e-44	1021	1286

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	147670.0026	Disease	p.ALA1123GLU	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0008	Disease	p.ALA1122THR	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS\|\|INSULIN RESISTANCE, INCLUDED
OMIM	147670.0021	Disease	p.ARG1140GLN	DIABETES MELLITUS, NONINSULIN-DEPENDENT
OMIM	147670.0030 147670.0037	Disease	p.ARG1162GLN	HYPERINSULINEMIC HYPOGLYCEMIA, FAMILIAL, 5
OMIM	147670.0018	Disease	p.ARG969GLN	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0025	Disease	p.ARG86PRO	DONOHUE SYNDROME
OMIM	147670.0004	Disease	p.ARG735SER	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0022	Disease	p.ARG372TER	DONOHUE SYNDROME
OMIM	147670.0019	Disease	p.ARG976TER	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0013	Disease	p.ARG988TER	RABSON-MENDENHALL SYNDROME
OMIM	147670.0036	Disease	p.ASN431ASP	DONOHUE SYNDROME
OMIM	147670.0012	Disease	p.ASN15LYS	RABSON-MENDENHALL SYNDROME
OMIM	147670.0016	Disease	p.ASN462SER	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0003	Disease	p.GLU672TER	DONOHUE SYNDROME
OMIM	147670.0020	Disease	p.GLY31ARG	DONOHUE SYNDROME
OMIM	147670.0024	Disease	p.GLY366ARG	DONOHUE SYNDROME
OMIM	147670.0001	Disease	p.GLY984VAL	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0014	Disease	p.HIS209ARG	DONOHUE SYNDROME
OMIM	147670.0033	Disease	p.ILE119MET	DONOHUE SYNDROME
OMIM	147670.0010	Disease	p.LEU233PRO	DONOHUE SYNDROME
OMIM	147670.0002	Disease	p.LYS460GLU	DONOHUE SYNDROME
OMIM	147670.0027	Disease	p.LYS121TER	DONOHUE SYNDROME
OMIM	147670.0031	Disease	p.MET1141ILE	INSULIN RESISTANCE
OMIM	147670.0011	Disease	p.PHE382VAL	DIABETES MELLITUS, INSULIN-RESISTANT
OMIM	147670.0009	Disease	p.TRP1188SER	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0032	Disease	p.TRP412SER	DONOHUE SYNDROME
OMIM	147670.0015	Disease	p.TRP133TER	DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS
OMIM	147670.0023	Disease	p.VAL28ALA	DONOHUE SYNDROME
OMIM	147670.0029	Disease	p.VAL973MET	DIABETES MELLITUS, NONINSULIN-DEPENDENT

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258