Results for the protein: NP

Results for the Protein: NP_001245284

385298694

3172

HNF4A

NCBI

hepatocyte nuclear factor 4-alpha isoform g [Homo sapiens]

Known Diseases associated with this Protein:
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
NONINSULIN-DEPENDENT DIABETES MELLITUS

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RefSeq Protein: NP_001245284

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
NR_DBD_VDR	cd06955	1.4e-24	45	143
NR_DBD_ROR	cd06968	3.3e-26	45	140
NR_DBD_PNR	cd06970	1.1e-30	45	135
NR_DBD_TLX	cd07163	9.2e-30	45	133
NR_DBD_GCNF_like	cd07169	2.8e-27	45	134
NR_DBD_DHR4_like	cd07168	1e-28	45	136
NR_DBD_ERR	cd07170	1.7e-18	47	145
NR_DBD_TR2_like	cd06967	7e-39	48	134
NR_DBD_REV_ERB	cd07166	2.6e-23	48	133
NR_DBD_ER	cd07171	1.9e-22	48	129
NR_DBD_AR	cd07173	3.4e-16	48	131
NR_DBD_RAR	cd06964	2.2e-31	49	131
NR_DBD_GR_PR	cd07172	2.7e-15	49	126
NR_DBD_EcR	cd07161	8.5e-27	50	141
NR_DBD_FXR	cd06962	9.1e-24	50	133
NR_DBD_RXR	cd06956	2e-39	51	127
NR_DBD_CAR	cd06966	7.2e-21	51	144
NR_DBD_NGFI-B	cd06969	1.6e-37	51	125
2DBD_NR_DBD1	cd07157	8.6e-12	51	133
NR_DBD_EcR_like	cd06959	3.2e-27	52	124
NR_DBD_TR	cd06961	6.8e-36	52	136
NR_DBD_Ppar	cd06965	6.3e-23	52	130
NR_DBD_PXR	cd07162	1.6e-24	52	134
NR_DBD_like	cd06916	6.9e-46	53	124
NR_DBD_PNR_like_2	cd06957	2.4e-31	53	133
NR_DBD_COUP_TF	cd06958	5.2e-34	53	125
NR_DBD_HNF4A	cd06960	4.3e-52	53	128
NR_DBD_GR_like	cd06963	3.6e-18	53	125
NR_DBD_PNR_like	cd07154	1.2e-31	53	124
NR_DBD_VDR_like	cd07156	9.4e-30	53	124
NR_DBD_Ppar_like	cd07158	5.6e-28	53	124
NR_DBD_PNR_like_1	cd07164	1.2e-33	53	130
NR_DBD_DmE78_like	cd07165	2.6e-26	53	133
NR_DBD_Lrh-1_like	cd07167	2.2e-26	53	148
2DBD_NR_DBD2	cd07179	1.7e-24	53	126
NR_DBD_ER_like	cd07155	2.7e-24	53	127
NR_LBD_PPAR	cd06932	6.7e-05	77	366
NR_LBD_TR	cd06935	4.9e-05	124	366
NR_LBD_EcR	cd06938	4.4e-06	126	369
NR_LBD_Nurr1_like	cd06945	2.4e-06	139	373
NR_LBD_ER	cd06949	2.7e-07	139	376
NR_LBD_DHR38_like	cd07072	0.00071	140	373
NR_LBD_Ftz-F1_like	cd06944	8.5e-11	141	379
NR_LBD_RXR_like	cd06943	1.3e-37	142	352
NR_LBD_Lrh-1	cd07069	1.2e-05	142	372
NR_LBD_SF-1	cd07070	2.7e-06	142	370
NR_LBD_HNF4_like	cd06931	1.5e-167	144	366
NR_LBD_COUP-TF	cd06948	2.2e-26	144	380
NR_LBD_PXR_like	cd06934	0.00014	145	366
NR_LBD_ERR	cd06946	2e-09	145	369
NR_LBD_LXR	cd06954	0.00015	145	366
NR_LBD_ER_like	cd07068	1.1e-12	145	375
NR_LBD_RAR	cd06937	0.00013	147	369
NR_LBD_DHR4_like	cd06953	2e-07	147	356
NR_LBD_TR2_like	cd06952	1.3e-08	148	366
NR_LBD_AR	cd07073	0.00062	149	385
NR_LBD_Tlx_PNR_like	cd06950	2.2e-14	150	356
NR_LBD_Dax1	cd07350	1.1e-08	152	365
NR_LBD_Dax1_like	cd06951	1.9e-10	170	365
NR_LBD_F1	cd06929	6.6e-13	174	348
NR_LBD_SHP	cd07349	2e-07	174	367
NR_LBD_F2	cd06930	4.3e-61	177	340
NR_LBD	cd06157	6.2e-49	178	340
NR_LBD_Sex_1_like	cd06942	0.00076	178	388
zf-C4	pfam00105	1.4e-45	51	120
Hormone_recep	pfam00104	4.6e-49	208	366
ZnF_C4	smart00399	3.8e-38	52	121
HOLI	smart00430	9.2e-47	184	340

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
OMIM	600281.0002	Disease	p.ARG147TER	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM	600281.0003	Disease	p.ARG120TRP	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM	600281.0001	Disease	p.GLN261TER	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM	600281.0007	Disease	p.MET357ARG	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 1
OMIM	600281.0004	Disease	p.VAL386ILE	NONINSULIN-DEPENDENT DIABETES MELLITUS

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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