Results for the protein: Q13464

Results for the Protein: Q13464

47605999

6093

ROCK1

NCBI, UniProt

ROCK1_HUMAN RecName: Full=Rho-associated protein kinase 1; AltName: Full=Renal carcinoma antigen NY-REN-35; AltName: Full=Rho-associated, coiled-coil-containing protein kinase 1; AltName: Full=Rho-associated, coiled-coil-containing protein kinase I; Short=ROCK-I; AltName: Full=p160 ROCK-1; Short=p160ROCK

			0 7 0 0 7

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Swiss-Prot Protein: Q13464

Identical to: NP_005397

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621		32	401
STKc_ROCK1	cd05622		32	402
STKc_TAO1	cd06635	1.2e-05	51	382
STKc_PAK1	cd06654	7.7e-09	52	362
STKc_PAK_I	cd06647	3e-14	53	360
STKc_PAK2	cd06655	3.2e-09	53	363
STKc_PAK3	cd06656	1.2e-09	53	368
STKc_myosinIIIA	cd06638	8.6e-10	56	338
STKc_myosinIIIB	cd06639	3.7e-10	56	339
STKc_JNK1	cd07875	0.00021	56	446
STKc_p38alpha_MAPK14	cd07877	3.8e-06	56	389
STKc_PAK4	cd06657	2.2e-08	57	365
STKc_PAK6	cd06659	1.1e-11	57	366
STKc_PAK5	cd06658	2.5e-08	57	363
STKc_MAP4K4_6	cd06636	2.1e-07	58	338
STKc_PAK_II	cd06648	1.1e-13	58	352
STKc_PAK	cd06614	7.3e-19	59	352
STKc_p38	cd07851	4.1e-08	59	397
STKc_CDK9	cd07865	1.2e-07	59	338
STKc_p38beta_MAPK11	cd07878	2.1e-06	59	399
STKc_p38delta_MAPK13	cd07879	0.00024	59	389
STKc_p38gamma_MAPK12	cd07880	1.4e-07	59	393
STKc_TAO3	cd06633	0.00022	60	382
STKc_JNK	cd07850	1.2e-07	60	435
PKc_MKK7	cd06618	1.1e-10	62	362
STKc_STK10_LOK	cd06644	7.2e-11	63	359
STKc_TAO	cd06607	8.9e-06	64	382
STKc_CDK10	cd07845	4.5e-07	64	357
STKc_JNK3	cd07874	0.00053	64	445
STKc_TAO2	cd06634	1e-05	65	378
STKc_ASK	cd06624	9.5e-13	67	338
STKc_MAP4K3	cd06645	2.6e-09	68	337
STKc_MAP4K5	cd06646	1.1e-08	68	337
STKc_ERK5	cd07855	5.3e-07	68	378
PTKc_ALK_LTK	cd05036	5.6e-07	69	311
PTKc_Csk_like	cd05039	0.00019	69	312
PTKc_Abl	cd05052	6.7e-06	69	337
PTKc_FAK	cd05056	0.0001	69	344
PTKc_Lck_Blk	cd05067	5.3e-05	69	355
PTKc_Frk_like	cd05068	9.1e-06	69	337
PTKc_Src	cd05071	0.00084	69	338
PTKc_Hck	cd05073	5.5e-05	69	336
PTKc_Fyn_Yrk	cd05070	3.8e-05	69	336
PTKc_Csk	cd05082	5.2e-05	69	336
PTKc_Lyn	cd05072	6.1e-06	69	336
PTKc_Yes	cd05069	0.00015	69	320
PTKc_EGFR	cd05108	0.00065	69	384
STKc_myosinIII_like	cd06608	1.1e-11	69	317
STKc_TNIK	cd06637	2.9e-08	69	338
STKc_TEY_MAPK_plant	cd07858	4.4e-07	69	396
PTKc_Trk	cd05049	3.9e-06	70	326
PTKc_Musk	cd05050	8.9e-05	70	335
PTKc_TrkA	cd05092	0.00014	70	339
PTKc_TrkB	cd05093	0.00044	70	350
PTKc_DDR2	cd05095	0.00057	70	338
PTKc_DDR_like	cd05097	0.00086	70	338
PKc_MEK1	cd06650	1.7e-05	70	422
PKc_MEK2	cd06649	1.7e-06	70	433
STKc_CDK12	cd07864	2.7e-09	70	338
PTKc_EphR	cd05033	0.00019	71	313
PTKc_Jak_rpt2	cd05038	9.5e-06	71	322
PTKc_InsR_like	cd05032	1.9e-06	71	319
PTKc_Tec_like	cd05059	1.4e-05	71	314
PTKc_EphR_A	cd05066	0.00022	71	337
PTKc_Jak2_Jak3_rpt2	cd05081	3.2e-05	71	367
PTKc_Chk	cd05083	0.0008	71	335
PTKc_Tie2	cd05088	0.00013	71	359
PTKc_Btk_Bmx	cd05113	4.1e-07	71	333
PTKc_Tec_Rlk	cd05114	4.7e-07	71	337
PTKc_Itk	cd05112	1.8e-05	71	313
PKc_MAPKK_Byr1_like	cd06620	1.1e-09	71	344
PKc_MKK4	cd06616	5e-10	71	356
STKc_SLK	cd06643	9.7e-10	71	353
STKc_MAP4K3_like	cd06613	2.7e-15	72	337
STKc_PCTAIRE_like	cd07844	2.6e-07	72	353
STKc_BUR1	cd07866	1.9e-09	72	338
STKc_PFTAIRE1	cd07869	0.00061	72	364
STKc_PFTAIRE2	cd07870	0.00032	72	356
STKc_PCTAIRE2	cd07872	1.1e-05	72	358
STKc_PCTAIRE1	cd07873	6.4e-05	72	350
STKc_PCTAIRE3	cd07871	3e-06	72	353
STKc_SLK_like	cd06611	1.8e-10	73	354
STKc_MST4	cd06640	1.7e-08	73	339
STKc_MEKK3_like	cd06625	3.2e-18	73	338
STKc_MST3	cd06641	5.7e-09	73	339
STKc_STK25-YSK1	cd06642	5.7e-10	73	339
STKc_MEKK3_like_1	cd06653	1.2e-13	73	338
STKc_MEKK2	cd06652	2.8e-08	73	339
STKc_MAPK15	cd07852	1.7e-08	73	374
STKc_ERK1_2_like	cd07849	6.6e-08	73	386
STKc_Sty1_Hog1	cd07856	1.2e-05	73	402
STKc_Nek6_Nek7	cd08224	1.4e-10	73	338
STKc_Nek6	cd08228	9.2e-13	73	338
STKc_Nek7	cd08229	2.2e-12	73	338
PTKc_Src_like	cd05034	0.00012	74	320
PTKc_Tie1	cd05089	7.5e-05	74	347
PTKc_Srm_Brk	cd05148	0.00063	74	327
STKc_ROCK_NDR_like	cd05573	6.9e-219	74	400
STKc_PKA	cd05580	2e-78	74	371
STKc_PDK1	cd05581	7.3e-75	74	338
STKc_phototropin_lik	cd05574	9.4e-57	74	364
STKc_DMPK_like	cd05597	1.9e-152	74	400
STKc_Sid2p_Dbf2p	cd05600	6.1e-56	74	401
STKc_NDR_like	cd05599	3e-114	74	406
STKc_CRIK	cd05601	4.4e-140	74	400
STKc_MAST	cd05609	1.6e-76	74	369
STKc_PRKX_like	cd05612	3.9e-77	74	372
STKc_MASTL	cd05610	1.2e-05	74	799
STKc_LATS	cd05598	9.9e-100	74	406
STKc_MRCK_alpha	cd05623	5.8e-141	74	401
STKc_NDR2	cd05627	9.3e-92	74	437
STKc_LATS2	cd05626	1.2e-74	74	406
STKc_MRCK_beta	cd05624	7.2e-141	74	400
STKc_NDR1	cd05628	3.7e-86	74	403
STKc_NDR_like_fungal	cd05629	9.7e-104	74	406
PKc_MAPKK	cd06605	6.5e-13	74	342
STKc_MST3_like	cd06609	2.8e-15	74	336
STKc_OSR1_SPAK	cd06610	6.7e-15	74	338
STKc_MST1_2	cd06612	5.8e-16	74	338
PKc_MEK	cd06615	8.4e-12	74	352
PKc_MKK3_6	cd06617	3.5e-09	74	357
PKc_MKK5	cd06619	2e-05	74	360
PKc_MAPKK_Pek1_like	cd06621	1.1e-09	74	356
PKc_MAPKK_PBS2_like	cd06622	2.8e-11	74	391
PKc_MAPKK_plant_like	cd06623	7.6e-20	74	343
STKc_NAK1_like	cd06917	3.2e-13	74	356
STKc_CDKL	cd07833	6.4e-10	74	338
STKc_CdkB_plant	cd07837	3.1e-10	74	339
STKc_CDC2L1	cd07843	5.3e-08	74	338
STKc_CDKL2_3	cd07846	7e-10	74	369
STKc_CDKL1_4	cd07847	9.6e-13	74	371
STKc_CDKL5	cd07848	1e-05	74	338
STKc_CDK6	cd07862	2e-05	74	364
SPS1	COG0515	2.7e-65	74	534
PTKc_EphR_B	cd05065	0.00087	75	337
PKc_STE	cd05122	1.3e-42	75	337
STKc_Yank1	cd05578	7.4e-64	75	338
STKc_cPKC	cd05587	9.6e-62	75	401
STKc_MSK_N	cd05583	1.4e-60	75	357
STKc_GRK4_like	cd05605	2.3e-42	75	359
STKc_MSK1_N	cd05613	4.2e-45	75	357
STKc_MSK2_N	cd05614	5.2e-52	75	402
STKc_cPKC_alpha	cd05615	6.6e-46	75	401
STKc_cPKC_beta	cd05616	1.9e-49	75	401
STKc_GRK6	cd05630	4.2e-31	75	359
STKc_GRK4	cd05631	7.1e-31	75	359
STKc_GRK5	cd05632	6.9e-37	75	359
STKc_Cdc7_like	cd06627	1.1e-16	75	338
STKc_MAPKKK_Byr2_lik	cd06628	4.5e-16	75	338
STKc_YSK4	cd06631	4.7e-10	75	338
STKc_MAPKKK	cd06606	2e-36	75	338
STKc_MEKK3	cd06651	5.8e-12	75	340
STKc_CCRK	cd07832	4.7e-14	75	339
STKc_Pho85	cd07836	8.2e-06	75	353
STKc_CDK7	cd07841	1.7e-10	75	349
STKc_MAPK	cd07834	5.6e-10	75	378
STKc_CDK8_like	cd07842	2.1e-05	75	338
STKc_NLK	cd07853	1.7e-06	75	424
STKc_CDK5	cd07839	4.3e-07	75	338
STKc_TDY_MAPK_plant	cd07859	5.5e-07	75	410
STKc_CDK2_3	cd07860	1.7e-06	75	353
STKc_CDK1_euk	cd07861	6e-07	75	353
STKc_CDK4	cd07863	0.0001	75	353
STKc_CDK8	cd07868	0.00082	75	368
STKc_MPK1	cd07857	1.2e-06	75	356
STKc_Nek	cd08215	2.7e-22	75	311
STKc_Nek2	cd08217	1e-16	75	338
STKc_Nek1	cd08218	1.2e-21	75	338
STKc_Nek3	cd08219	1e-18	75	337
STKc_Nek9	cd08221	1.4e-11	75	338
STKc_Nek11	cd08222	1.5e-07	75	338
STKc_Nek4	cd08223	1.4e-14	75	338
STKc_Nek8	cd08220	1.7e-16	75	338
STKc_Nek5	cd08225	6.2e-22	75	338
STKc_Nek10	cd08528	1.2e-08	75	329
STKc_FA2-like	cd08529	1e-13	75	324
STKc_CNK2-like	cd08530	1.2e-13	75	329
PTKc_Axl_like	cd05035	0.0009	76	333
PTKc_Tyro3	cd05074	0.00031	76	333
STKc_CMGC	cd05118	3.5e-14	76	338
STKc_PKN	cd05589	9.7e-64	76	400
STKc_LATS1	cd05625	3.3e-73	76	406
STKc_MAPKKK_Bck1_lik	cd06629	4.8e-10	76	338
STKc_CDK_like	cd07829	1.1e-14	76	338
STKc_MAK_like	cd07830	2.8e-12	76	338
STKc_MOK	cd07831	9.7e-13	76	338
STKc_CDK1_like	cd07835	2e-08	76	353
STKc_CDK4_6_like	cd07838	1.3e-10	76	338
STKc_CDK9_like	cd07840	1.1e-10	76	338
STKc_MAPK4_6	cd07854	0.00087	76	379
PTKc_Tyk2_rpt2	cd05080	0.00044	77	364
PK_STRAD	cd08216	1.9e-07	77	358
PK_STRAD_alpha	cd08227	0.00015	77	430
STKc_RSK_N	cd05582	6.5e-59	79	400
STKc_p70S6K	cd05584	3.1e-62	79	402
STKc_Rim15_like	cd05611	4.5e-21	79	344
PTKc	cd00192	3.5e-09	80	337
PTKc_Ack_like	cd05040	9.4e-05	80	319
PTKc_Fes_like	cd05041	3.2e-10	80	311
PTKc_c-ros	cd05044	1.2e-05	80	335
PTKc_Tie	cd05047	0.0004	80	330
PTKc_Met_Ron	cd05058	0.00033	80	338
PTKc_Syk_like	cd05060	0.00049	80	304
PTKc_Fes	cd05084	1.1e-05	80	338
PTKc_Fer	cd05085	7.6e-05	80	338
PTKc_Syk	cd05116	1.2e-05	80	338
STKc_PKC	cd05570	8.4e-55	80	400
STKc_PKB	cd05571	2.8e-66	80	402
STKc_SGK	cd05575	1.7e-59	80	400
STKc_nPKC_eta	cd05590	4.5e-62	80	401
STKc_nPKC_epsilon	cd05591	3.4e-62	80	401
STKc_nPKC_theta_delt	cd05592	1.3e-61	80	402
STKc_PKB_gamma	cd05593	4.8e-45	80	405
STKc_PKB_alpha	cd05594	3.1e-47	80	403
STKc_PKB_beta	cd05595	6.6e-53	80	408
STKc_aPKC	cd05588	9.1e-51	80	401
STKc_SGK1	cd05602	4.7e-49	80	402
STKc_SGK3	cd05604	1.7e-50	80	402
STKc_SGK2	cd05603	1.2e-47	80	401
STKc_aPKC_iota	cd05618	5.6e-42	80	401
STKc_nPKC_theta	cd05619	1.9e-48	80	402
STKc_nPKC_delta	cd05620	5e-41	80	402
STKc_aPKC_zeta	cd05617	4.2e-40	80	401
STKc_MEKK1	cd06630	1.9e-10	80	339
STKc_MEKK1_plant	cd06632	1.6e-13	80	338
STKc_MEKK4	cd06626	1.2e-13	80	338
STKc_beta_ARK	cd05606	9.6e-41	81	358
STKc_GRK3	cd05633	4.4e-30	81	359
PKc	cd00180	2.7e-68	82	336
PTKc_Zap-70	cd05115	0.00034	82	338
STKc_AGC	cd05123	4.1e-130	82	338
STKc_cGK_PKG	cd05572	1.1e-65	82	345
STKc_GRK	cd05577	2.5e-33	82	358
STKc_YPK1_like	cd05585	1.8e-72	82	399
STKc_Sck1_like	cd05586	2.9e-58	82	433
STKc_MAST_like	cd05579	2.9e-89	82	343
STKc_GRK7	cd05607	6.2e-35	82	358
STKc_GRK1	cd05608	1.6e-37	82	358
HR1	cd00089	2e-18	450	530
PH_ROCK	cd01242	8.1e-145	1120	1318
PH	cd00821	6.7e-48	1121	1315
PH-like	cd00900	6e-56	1121	1315
PH_MRCK	cd01243	0.00012	1122	1216
C1	cd00029	1.5e-13	1229	1281
Pkinase_Tyr	pfam07714	1.4e-12	76	316
STYKc	smart00221	3.3e-88	76	338
TyrKc	smart00219	1.4e-10	76	316
S_TKc	smart00220	4.4e-98	86	338
S_TK_X	smart00133	5.5e-10	341	401
Rho_Binding	pfam08912	1.6e-35	949	1014
PH	smart00233	3.7e-46	1119	1350
C1	smart00109	1e-12	1229	1283

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041060	Polymorphism	p.ARG1262GLN	N/A
Swiss-Prot	VAR_041061	Polymorphism	p.CYS1264ARG	N/A
Swiss-Prot	VAR_041059	Polymorphism	p.GLN1217GLU	N/A
Swiss-Prot	VAR_041058	Polymorphism	p.PRO1193SER	N/A
Swiss-Prot	VAR_041055	Polymorphism	p.SER108ASN	N/A
Swiss-Prot	VAR_041057	Polymorphism	p.THR1112PRO	N/A
Swiss-Prot	VAR_041056	Polymorphism	p.THR773SER	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258